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Volume 47(1); Jan 2004
Clinical Lecture
Continuous Renal Replacement Therapy in Pediatrics
Hyewon Hahn, Young Seo Park
Korean J Pediatr. 2004;47(1):1-5.   Published online January 15, 2004
Medical Lecture Course
Innate Immunity and Toll Like Receptors
Kyung Hyo Kim
Korean J Pediatr. 2004;47(1):6-11.   Published online January 15, 2004
Original Articles
Clinical Analysis of Pediatric Death Patients Visiting Emergency Center
Do Hyun Kim, Seong Hun Lee, Sang Bae Lee, Min Hyuk Ryu, Dong Jin Lee
Korean J Pediatr. 2004;47(1):12-17.   Published online January 15, 2004
Purpose : We analyzed pediatric death patients who visited Dong-Kang Hospital emergency center, in order to minimize unexpected pediatric deaths. Methods : The authors analyzed retrospectively the medical records of 110 pediatric patients who died before and within 24 hours after admission to the emergency center of Ulsan Dong-Kang General Hospital from January 1997 to December 2002. Results : We classified three...
Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea
Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung
Korean J Pediatr. 2004;47(1):18-23.   Published online January 15, 2004
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a...
Study of Exchange Phenomenon of Mycoplasma pneumoniae in Children from 1997-2002
Sung Seok Kim, Hoon Kang, Byung Moon Ahn, Won Wook Lee, Eun Ryoung Kim, Soo Yeon Kim, Hyun Pil Cho
Korean J Pediatr. 2004;47(1):24-30.   Published online January 15, 2004
Methods : We enrolled 504 patients out of 547 patients, who were admitted to the Department of Pediatrics, Sung-Ae and Kwangmyung Sung-Ae General Hospital from November 1996 to October 2002. They were diagnosed as M. pneumoniae pneumonia by clinical characteristics and indirect particle agglutination test of M. pneumoniae. To classify into two groups, the group specific polymerase chain reaction amplification...
Clinical Observation of Mesenteric Lymphadenitis in Children
Chul Han Park, Dong Hoon Lee, Hye Lim Kim, Ji Min Park, Jin Bok Hwang, Heung Sik Kim, Hee Jung Lee
Korean J Pediatr. 2004;47(1):31-35.   Published online January 15, 2004
Purpose : Mesenteric lymphadenitis is classified into acute and chronic, specific and nonspecific types according to clinical aspect and causative disease. We under took this study to find out clinical aspects, associated diseases and hospital course of mesenteric lymphadenitis in children. Methods : We examined 98 children aged from 18 months to 14 years who visited Dongsan Medical Center for abdominal...
Mid-term Result of the Transcatheter Occlusion of Patent Ductus Arteriosus with Duct-Occlud Device and Procedure-Related Problems
Yuria Kim, Jae Young Choi, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee, Young Hwan Park, Bum Koo Cho
Korean J Pediatr. 2004;47(1):36-43.   Published online January 15, 2004
Purpose : We will present our mid-term result of transcatheter closure of PDA with Duct-Occlud device(pfm. AG. Germany) after 12 months follow up and report the problems during the procedure. Methods : In total 154 patients, the Duct-Occlud devices were inserted in our institute from March, 1996 to August, 2002. Three types of Duct-Occlud device, i.e standard, reinforced, reinforced reverse cone...
Pulmonary Venous Flow Doppler Pattern in Infant Atrial Septal Defect Cases
Kyung Shin Rhee, Youngshin Park, Jeong Jin Yu, Chang Hwi Kim
Korean J Pediatr. 2004;47(1):44-48.   Published online January 15, 2004
Purpose : Doppler findings of pulmonary venous flow in large atrial septal defect(ASD) has been known to show a contiguous form rather than showing a form with two peaks in a cardiac cycle. The aim of this study was to find out the affecting variables in flow pattern change. Methods : The present study was conducted on 16 isolated secondum ASD...
Abnormality of Regional Wall Motion of the Left Ventricle in Children with Ventricular Diastolic Overload
Yeo Hyang Kim, Sang Bum Lee
Korean J Pediatr. 2004;47(1):49-54.   Published online January 15, 2004
Purpose : To assess the regional wall motion of the left ventricle in patients with diastolic overloaded lesions of congenital heart diseases with centerline analysis and radial method. Methods : This study included 96 children with congenital heart diseases admitted to Kyungpook National University Hospital from January 1998 to December 2002 who received left ventriculograms. The evaluation of the regional wall...
Clinical Experience of 60 Pediatric Renal Transplantations at a Single Center
Sun Youn Lee, Hyewon Han, Young Seo Park, Duck Jong Han
Korean J Pediatr. 2004;47(1):55-65.   Published online January 15, 2004
Purpose : Renal transplantation for the management of end-stage renal disease(ESRD) in children is now the optimal treatment. We analyzed the clinical courses and characteristics of pediatric renal transplantation in Asan Medical Center. Methods : We reviewed the charts of 60 cases of renal transplantation under the age of 18, admitted to Asan Medical Center, from Oct. 1990 to May 2003....
Outcome after Discontinuation of Antiepileptic Drugs in Well Controlled Epileptic Children - Recurrence and Related Risk Factors
Hyo-Bin Kim, Su Jeong You, Tae-Sung Ko
Korean J Pediatr. 2004;47(1):66-75.   Published online January 15, 2004
Purpose : There has been no exact criteria established for when to discontinue antiepileptic drugs (AEDs) in epileptic children who had been well controlled for a long period. This study was undertaken to evaluate the recurrence rate and predictive risk factors of relapse after discontinuation of AEDs in epileptic children who had been seizure-free. Methods : We retrospectively studied 294 children...
Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children
Hye Rim Chung, Choong Ho Shin, Sei Won Yang
Korean J Pediatr. 2004;47(1):76-80.   Published online January 15, 2004
Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children. Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,...
Comparison of Serum Proteome Maps of Children with Kawasaki Disease
Seoung Yon Baek, Young-Mock Lee, Kwang Hoon Lee, Dong Soo Kim
Korean J Pediatr. 2004;47(1):81-89.   Published online January 15, 2004
Purpose : Kawasaki disease is a systemic vasculitis observed in children under five years of age and the leading cause of pediatric acquired heart disease, but its pathophysiology is still not completely understood. With proteomics, the study of quality and quantity of proteins, having been developed dramatically, we tried to find a way to evaluate the etiology and pathogenesis of...
Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
Korean J Pediatr. 2004;47(1):90-94.   Published online January 15, 2004
Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD). Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation...
Case Reports
A Case of Congenital Megacystis Due to Non-Obstructive Urinary Retention Associated with Intestinal Malrotation and Hypoperistalsis
Tai Young Ham, Jeong Hoon Kim, Ji Hong Kim, Jae Seung Lee, Seok Ju Han, Choon Sik Yoon, Soon Won Hong
Korean J Pediatr. 2004;47(1):95-99.   Published online January 15, 2004
Congenital megacystis with bilateral hydroureteronephrosis is most commonly associated with posterior urethral valves, prune-belly syndrome, vesicoureteral reflux, or nonrefluxing, nonobstructive megaureters. Among the other cause of congenital megacystis, megacystis-microcolon-intestinal hypoperistalsis syndrome(MMIHS), which is characterized by megacystis, microcolon and hypoperistalsis of the intestines with resultant abdominal distension, is a rare cause of functional obstruction of urinary tracts in childhood. It was...
A Case of 2-Methylbutyryl-CoA Dehydrogenase Deficiency
Moon Souk Lee, Ho Jin Park, In Kyu Lee, Kyuchul Choeh, Hye-Ran Yoon
Korean J Pediatr. 2004;47(1):100-105.   Published online January 15, 2004
We report a one-day-old Korean boy with 2-Methylbutyryl-CoA dehydrogenase(2-MBCDase) deficiency detected by urine organic acid and acylglycine analysis, plasma acylcarnitine analysis and confirmed by enzyme assay and Western blot. The patient was born at 35 weeks and three days with oligohydroamnios and premature rupture of membrane for 31 hours, as a second child of healthy non-consanguineous parents. There was no...
Four Cases of Staphylococcal Scalded Skin Syndrome
Chul Han Park, Yoo Jin Jeong, Won Jung Choi, Sat Byul Park, Heung Sik Kim, Chin Moo Kang
Korean J Pediatr. 2004;47(1):106-110.   Published online January 15, 2004
Staphylococcal scalded skin syndrome is a systemic disease with a clinical spectrum ranging from subcorneal pustules, patterned exfoliation to extensive erosion and peeling of skin by the exfoliative toxin of group II Staphylococcus aureus. This disease occurs mainly in infancy and children below five years and it isn't easy to differentiate from other vesicular diseases clinically, but skin biopsy shows...
A Case of Tyrosinemia Type 1 with Cytomegalovirus Infection
Jin Hyung Cho, Kyu Jin Shim, Sung Koo Kim, Seon Hee Shin, Kon Hee Lee, Hae Sun Yun
Korean J Pediatr. 2004;47(1):111-114.   Published online January 15, 2004
Tyrosinemia type 1 is an autosomal recessive inborn error of tyrosine metabolism that caused a mutation in the gene coding for the enzyme fumarylacetoacetate hydrolase(FAH). As a result, maleylacetoacetate(MAA) and fumarylacetoacetate(FAA) are formed. The accumulated FAA is converted into succinylacetone(SA) and succinylacetoacetate(SAA) which are excreted in urine. The first report with typical clinical and biochemical findings was presented by Sakai...