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Volume 48(5); May 2005
Clinical Lectures
Approach to the Children with Recurrent Infections
Jae Ho Lee
Korean J Pediatr. 2005;48(5):461-468.   Published online May 15, 2005
The major function of immune system is to protect infections. The immune systems are composed of innate and adaptive immunity. In adaptive immunity, the cellular and humoral components interact each other. Neonates and infants are infected frequently, because immune systems are naive and easy to expose to infectious agents. The complete history and physical examination is essential to evaluate the...
The Effects of Postpartum Depression on the Development of Children
Esook Oh
Korean J Pediatr. 2005;48(5):469-475.   Published online May 15, 2005
Mother-infant interaction is a crucial component of an infant's cognitive, emotional and behavioral development. Most people are preoccupied with fetal education, the physical conditions of the postpartum mother and baby, and emphasizing an early start in the child's education. However, the effects of a mother's postnatal emotional state on the development of the infant are often overlooked. Postpartum depression is...
Tacrolimus versus Cyclosporine Immunosuppression in Pediatric Renal Transplantation : Pharmacokinetic Consideration
Jung Sue Kim
Korean J Pediatr. 2005;48(5):476-480.   Published online May 15, 2005
Immunosuppressive therapy in pediatric renal transplant recipients is changing consequence of the increasing number of available immunosuppressive agents. The optimal use of immunosuppressive agents requires a thorough understanding of the pharmacokinetic characteristics, but the information on the pharmacokinetic characteristics of these drugs in pediatric transplant recipients is still limited. In general, patients younger than 5 years old show higher clearance...
Original Articles
Serum Adiponectin Levels and Insulin Resistance in Obese Children
Hee-Sun Lee, Jin Lee, Min-Joo Kang, Byung-Min Choi, Kee-Hyoung Lee
Korean J Pediatr. 2005;48(5):481-487.   Published online May 15, 2005
Purpose : Adiponectin, adipose tissue-specific protein, has anti-inflammatory and anti-atherogenic properties. It has been found to have a negative correlation with obesity and to play a role in modulating glucose tolerance and insulin sensitivity. Serum adiponectin concentrations are decreased in adults with obesity and type 2 diabetes. We investigated the difference in adiponectin levels between obese and non-obese children, and...
Extubation Time by Birth Weight and the Predictors for Success/Failure at the First Extubation in Extremely Low Birth Weight Infants
Chang Won Choi, Sung Eun Park, Ga Won Jeon, Eun Jung Yoo, Jong Hee Hwang, Yun Sil Chang, Won Soon Park
Korean J Pediatr. 2005;48(5):488-494.   Published online May 15, 2005
Purpose : To outline the aspects of extubation by birth weight and find the predictors for success/ failure at the first extubation in extremely low birth weight infants. Methods : One hundred thirteen extremely low birth weight infants(<1,000 g) who were admitted to NICU at Samsung Seoul Hospital between Jan. 2000 and Jun. 2004 were enrolled. Clinical characteristics that are thought...
Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes
Eun Hwa Choi, Hee Sup Kim, Stephen J. Chanock, Hoan Jong Lee
Korean J Pediatr. 2005;48(5):495-499.   Published online May 15, 2005
Purpose : Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in Korean children with a common haplotype of the IL4 promoter. This study was performed to investigate functional differences of the variant IL4 promoter haplotypes. Methods : Genomic DNA was obtained...
A Study of Antibody Conversion Rate During a Mycoplasma pneumoniae Epidemic Period(the Second Half of 2003)
Do Kyun Kim, Young Yoo, Jinho Yu, Young Yull Koh
Korean J Pediatr. 2005;48(5):500-505.   Published online May 15, 2005
Purpose : This study was designed to estimate the prevalence of Mycoplasma pneumoniae infection during an epidemic period by means of examining the antibody conversion rate and to investigate the association of the antibody conversion with age, initial antibody titer, and atopy. Methods : We chose 191 children whose antibody titer to M. pneumoniae was negative, 1 : 40, or...
Functional Immunity to Cross-Reactive Serotype 6A Induced by Serotype 6B in Pneumococcal Polysaccharide Vaccine
Kyung Hyo Kim
Korean J Pediatr. 2005;48(5):506-511.   Published online May 15, 2005
Purpose : Streptococcus pneumoniae serotype 6B and 6A are important pathogens in pneumococcal infections. It is commonly assumed that the 6B vaccines elicit antibodies cross-reacting with the 6A serotype and the cross-reactive antibodies protect against infections of 6A. To examine this assumption, we measured the opsonophagocytic capacity to serotype 6A and 6B in adults. Methods : Twenty-four adults were immunized...
Airway Expandible Metallic Stent Implantation in Children with Tracheal or Bronchial Stenosis
Ju Young Jang, Hyo-Bin Kim, So Yeon Lee, Ja Hyung Kim, Seong Jong Park, Ji Hoon Shin, Soo-Jong Hong
Korean J Pediatr. 2005;48(5):512-517.   Published online May 15, 2005
Purpose : In adults, endoscopic tracheobronchial balloon dilatation and stenting have become valuable methods to establish and maintain an adequate airway lumen when tracheomalacia or neoplastic growth compromise the airways. But in children, only a few cases were reported due to technical problems. We report six children who were treated with stent implantation and describe the use and safety of...
The Efficacy of Nebulized 3 Percent Hypertonic Saline Solution and Fenoterol in Infants with Bronchiolitis
Joon Young Park, Young Mi Jeong, Soo Jin Jeong, Son Sang Seo
Korean J Pediatr. 2005;48(5):518-522.   Published online May 15, 2005
Purpose : To evaluate the effect of inhaled hypertonic saline solution in hospitalized infants with bronchiolitis. Methods : A randomized double blind trial was performed from October 2003 to May 2004. A total of eighty patients <1 year of age with a clinical diagnosis of acute viral bronchiolitis were enrolled and assigned to receive either of the following : inhalation of...
Difference of Clinical Features according to Hypoalbuminemia in the Children with Pleural Effusion
Min-Jung Sung, Hee-ju Park
Korean J Pediatr. 2005;48(5):523-526.   Published online May 15, 2005
Purpose : Hypoalbuminemia is a rare cause of pleural effusion. The relationship between the severity of hypoalbuminemia and the clinical course of pleural effusion is unclear. The aim of this study was to evaluate the change of clinical course according to the severity of hypoalbuminemia due to pleural effusion in children. Methods : A total of 96 patients admitted to Pusan...
Bone Mineral Density and Bone Markers in the Children with Epilepsy Taking on Chronic Anticonvulsants
Soon Bum Lee, So Young Kang, Jeesuk Yu
Korean J Pediatr. 2005;48(5):527-533.   Published online May 15, 2005
Purpose : Long-term administration of anticonvulsants in children with epilepsy may cause short stature, hypocalcemia and low bone mineral density. This study was performed for the early detection of abnormal bone metabolism in children with epilepsy on taking anticonvulsants. Methods : Thirty children aged 5 to 16 years who were diagnosed with epilepsy were enrolled in this study. All had taken...
Chest X-ray Findings and Serum Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
Ji Young Kim, Jung Hyun Kwon, Kyung Hyo Kim, Jung Hyun Yu, Young Mi Hong
Korean J Pediatr. 2005;48(5):534-538.   Published online May 15, 2005
Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology. Many complications other than cardiovascular involvement have been recognized in KD. However, there have been few reports published concerning involvement of the lungs in this disease. The purpose of this study was to examine the relationship between serum TNF-α, the degree of coronary artery dilatation and chest X-ray(CXR)...
The Change of Serum Soluble E-selectin in Kawasaki Disease
Jae-Ho Jeong, Eun-Young Cho, Jae-Woo Lim, Eun-Jeong Cheon, Kyong-Og Ko, Kyung-Il Lee
Korean J Pediatr. 2005;48(5):539-544.   Published online May 15, 2005
Purpose : The aim of this study was to investigate the pathophysiologic role of serum E-selectin, vascular endothelial growth factor(VEGF)-induced cell adhesion mollecule in Kawasaki disease(KD) and to look for the evidence of direct relationship between the plasma levels of soluble E-selectin and the incidence of coronary artery lesion(CAL). Methods : Changes in plasma levels of sE-selectin(n=98) over time were...
Single Cell Dissociation Methods for Flow Cytometric Cell Death Analysis of Hypoxia-Ischemia Injured Newborn Rat Pup Brain
Jong Hee Hwang, Dong Kyung Sung, Chang Won Choi, Saem Kang, Yun Sil Chang, Won Soon Park, Munhyang Lee
Korean J Pediatr. 2005;48(5):545-550.   Published online May 15, 2005
Purpose : Newborn brain tissue has to be dissociated into a single cell suspension for flow cytometric analysis of cell death during hypoxia-ischemia. Thus the development of a method to dissociate cells from the brain tissue with least damage and maintenance of membrane and antigen integrity remains the challenge for the in vivo application of this technique. We evaluated the...
Case Reports
A Case of Wiskott-Aldrich Syndrome with Novel Mutation in Exon 2 of the WASP Gene
Hyuk Lee, Jung In Park, Sun Young Kim,, Kyeung Hee Moon, Ho Keun Yi, Pyoung Han Hwang
Korean J Pediatr. 2005;48(5):551-556.   Published online May 15, 2005
Wiskott-Aldrich syndrome(WAS) is an X-linked recessive immunodeficiency characterized by thrombocytopenia with small platelet volume, eczema, and recurrent infections, and is also characterized by increased incidence of auto immune diseases and malignancies. The phenotype observed in this syndrome is caused by mutation in the Wiskott-Aldrich syndrome protein(WASP) gene localized to the proximal short arm of the X chromosome and recently isolated...
A Case of Congenital Laryngeal Atresia with Single Umbilical Artery Who Required a Tracheotomy
Ho Sung Wi, Hey Sung Baek, Jae Won Oh, Myung-Kul Yum, Yong Joo Kim, Soo Jee Moon, Kyung Tae, Chang-Ryul Kim
Korean J Pediatr. 2005;48(5):557-560.   Published online May 15, 2005
Congenital laryngeal atresia is a rare cause of airway obstruction that is almost always lethal within a few minutes after birth. Therefore congenital laryngeal atresia should be diagnosed in the prenatal period. If not, it should be considered in newborn infant with life-threatening symptoms at birth such as cyanosis and dyspnea that need emergent procedures like a tracheotomy. We report...
Isolated 3-Methylcrotonyl CoA Carboxylase Deficiency Detected by Newborn Screening Program Using Tandem Mass Spectrometry
Ju Young Kwak, Jun Young Park, Kyung A Nam, Sang Hi Son, Son Sang Seo
Korean J Pediatr. 2005;48(5):561-564.   Published online May 15, 2005
Isolated deficiency of 3-methylcrotonyl CoA carboxylase is a rare disorder of the catabolic pathway for leucine and many patients have mild symptoms or no symptom. However, the introduction of tandem mass spectrometry in newborn screening has revealed an unexpectedly high incidence of this disorder. We report an asymptomatic premature infant with isolated 3-methylcrotonyl CoA carboxylase deficiency detected by newborn screening...
A Case of Acute Renal Failure Caused by Rhabdomyolysis due to Hyperosmolar Nonketotic Coma in Children
Jeong Won Kwak, Jae Min Oh, Su Yung Kim
Korean J Pediatr. 2005;48(5):565-568.   Published online May 15, 2005
Hyperosmolar nonketotic coma complicated in diabetes mellitus has been a rare cause of rhabdomyolysis, although increasingly reported recently. Acute renal failure can be complicated in 15 percent of rhabdomyolysis patients, but is rare in the case of rhabdomyolysis caused by diabetic hyperosomolar nonketotic coma. We report a 14 years-old boy with acute renal failure complicated by rhabdomyolysis caused by diabetic...
A Case of Chylous Mesenteric Cyst in a Neonate
Hyun Taek Lim, Jung Hwa Lee, So Hee Lee, Jeong Eun Kim, Seong Jin Hong, Young Chil Choi, Sang Yun Kim
Korean J Pediatr. 2005;48(5):569-571.   Published online May 15, 2005
Mesenteric cysts are one of the least common intraabdominal lesions, which are very rare in neonates. Among mesenteric cysts, a chylous cyst is the rarest one of all. This entity can be found anywhere in the gastrointestinal tract from the duodenum to the rectum. Mesenteric cysts may be asymptomatic and found on routine examinations, or can present with symptoms such...
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