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Volume 50(7); Jul 2007
Review Articles
Acute lymphoblastic leukemia in children: past, present and future
Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn
Korean J Pediatr. 2007;50(7):601-605.   Published online July 15, 2007
The cure rate of acute lymphoblastic leukemia (ALL) in children dramatically improved over past 5 decades from zero to about 80%. The main cause of improvement is owing to the development of chemotherapy by multicenter clinical trial of large study groups with the understanding of leukemia biology. Recently, pediatric ALL protocols were applied to the treatment of adolescent and even...
Solid tumors in childhood: risk-based management
Hong Hoe Koo
Korean J Pediatr. 2007;50(7):606-612.   Published online July 15, 2007
Since the introduction of chemotherapy for the treatment of childhood leukemia more than 50 years ago, the results of childhood cancer have improved dramatically. The 5-year survival rate of disease, many of which were uniformly fatal in the prechemotherapy era, reached to more than 75%. This remarkable improvement in survival is a direct result of the incorporation of chemotherapeutics into...
Hematopoietic stem cell transplantation : overview for general pediatrician
Tai Ju Hwang
Korean J Pediatr. 2007;50(7):613-621.   Published online July 15, 2007
Hematopoietic stem cell transplantation (HSCT) has expanded and evolved substantially in the last decades to treat various malignant and nonmalignant diseases. However, the conditioning regimen can lead to transplantation related death by major organ dysfunction, severe infection and bleeding. In the allogeneic setting, graft versus host disease may also develop, making post-transplant management complex. To overcome these problems, new stem...
Original Articles
An analysis of one-year experience of pediatric observation unit: The first report in Korea
Jee Young Lee, Ui-Yoon Choi, Soo Young Lee, Ji-Young Lee, Byong Chan Lee, Hui Sung Hwang, Hye Rin Mok, Dae Chul Jeong, Seung Yun Chung, Jin Han Kang
Korean J Pediatr. 2007;50(7):622-628.   Published online July 15, 2007
Purpose : While pediatric observation units (POU) have become a common practice in hospitals throughout developed countries, there has been no report about POUs in Korea so far. The aims of this study were to analyze our one-year's experience of the POU and to decide which disease entities are suitable for the POU. Methods : All children admitted from...
The novel expression method of pediatric body composition : fat mass index and fat-free mass index
Young Gyu Cho, Jae Heon Kang, Hye Ryoung Song, Kyung A Kim, Ji Hyun Song, Myeong Ho Jung
Korean J Pediatr. 2007;50(7):629-635.   Published online July 15, 2007
Purpose : This study was conducted to assess the usefulness of fat-free mass index (FFMI) and fat mass index (FMI) as novel expression methods of body composition in children. Methods : A total of 466 Second grade students-248 boys and 218 girls- from all elementary schools the Gwacheon City underwent anthropometric measures including bioelectrical impedance analysis (BIA) and biochemical tests. The...
Fluconazole prophylaxis in high-risk, very low birth weight infants
Soo Young Kim, Soon Joo Lee, Mi Jeong Kim, Eun Song Song, Young Youn Choi
Korean J Pediatr. 2007;50(7):636-642.   Published online July 15, 2007
Purpose : Fluconazole prophylaxis for very low birth weight (VLBW) infants has been shown to reduce invasive fungal infection and its mortality. This study aims to evaluate the effect of fluconazole prophylaxis in VLBW infants on the incidence and mortality of fungal infection. Methods : VLBW infants with endotracheal intubation and central vascular access admitted to the Neonatal Intensive Care...
Platelet count and mean platelet volume in low birth weight infants (≤2,000 g) with sepsis
Wan-soo Lee, Jin-young Cho, Seung-taek Yoo, Chang-woo Lee, Doo-young Choi, Jong-duck Kim, Yeon-kyun Oh
Korean J Pediatr. 2007;50(7):643-648.   Published online July 15, 2007
Purpose : Sepsis is a common complication in Neonatal Intensive Care Units (NICU), seen especially in low birth weight (LBW) infants. A recent study showed that fungal or gram-negative sepsis is associated with a greater degree of thrombocytopenia than is seen with gram-positive sepsis. So, this study was undertaken to examine the platelet counts and platelet indices in LBW infants...
Clinical characteristics of deep neck abscess in children; 15 year experience in a university hospital
Min-Ji Goo, Jeong-Suk Yeom, Eo-Jin Kim, Jung-Je Park, Ji-Hyun Seo, Eun-Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Korean J Pediatr. 2007;50(7):649-654.   Published online July 15, 2007
Purpose : The objective of this study was to clarify the presentation, associated preceding illness, pathologic organisms, treatment and outcome of deep neck abscess in children according to age and location. Methods : We retrospectively reviewed the in-patient charts of children treated at our hospital for deep neck abscess. Thirty-five such patients were identified as having been treated...
Characteristics of functional gastrointestinal disorders in children with chronic abdominal pain
Ji Hyun Uhm
Korean J Pediatr. 2007;50(7):655-659.   Published online July 15, 2007
Purpose : The aim of this study was to document the causes of chronic abdominal pain in children referred to a hospital setting and evaluate the frequency and characteristics of functional gastrointestinal disorder (FGID) classified by Rome III criteria. Methods : One hundred thirty two patients with chronic abdominal pain were evaluated. Examinations were performed in order to find organic...
The effectiveness of urokinase in treatment of pleural effusion in children
Ga-yeon Nam, Hee-ju Park
Korean J Pediatr. 2007;50(7):660-664.   Published online July 15, 2007
Purpose : Pleural effusion is a common complications of pediatric bacterial pneumonia. Intrapleural administration of fibrinolytic agents such as urokinase have been used in the management of complicated parapneumonic effusions. But the safety and effectiveness of intrapleural urokinase instillations in children has not been confirmed. The aim of this study is to evaluate the safety and effectiveness of intraperitoneal urokinase...
Clinical features and results of recent neonatal cardiac surgery - A review of 82 cases in one hospital
Ki Won Oh, Jung Ok Kim, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee
Korean J Pediatr. 2007;50(7):665-671.   Published online July 15, 2007
Purpose : The purpose of this study was to investigate the clinical features and outcome in newborns undergoing cardiac surgery. Methods : Eighty two neonates underwent heart surgery for congenital heart defect at Kyungpook National University Hospital between March 2000 and February 2006. Patient characteristics (sex, age, diagnosis), pre-operative conditions, operation type, postoperative complications and mortality were reviewed retrospectively. Results : In...
Epidemiology and clinical characteristics of headache comorbidity with epilepsy in children and adolescents
Young Il Rho
Korean J Pediatr. 2007;50(7):672-677.   Published online July 15, 2007
Purpose : To assess the prevalence and characteristics of headache comorbidity with epilepsy in children and adolescents in a specialty epilepsy clinic. Methods : Two hundred twenty nine consecutive patients attending the Chosun University Hospital Pediatric Epilepsy Clinic (mean age 10.0?.1 years, range 4-17, M:F ratio 1.1:1.0) were interviewed with a standardized headache questionnaire. Headache was classified according to the...
Growth promoting effect of combined gonadotropin releasing hormone analogue and growth hormone therapy in early pubertal girls with predicted low adult heights
Eun-Jeong Hong, Heon-Seok Han
Korean J Pediatr. 2007;50(7):678-685.   Published online July 15, 2007
Purpose : Recent reports pointed out that gonadotropin releasing hormone analogue (GnRHa) therapy alone is not so promising for improving adult height in precocious puberty. So, that we studied the growth promoting effect of combined therapy with GnRHa and growth hormone (GH) in early pubertal girls. Methods : Twenty three early pubertal girls (9.73?.59 yr) with predicted adult heights (PAH) below...
The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
Ji Young Kim, Seung Ho Yang, Sun Hwa Cha, Ji Yeun Kim, Young Chae Jang, Kwan Kyu Park, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
Korean J Pediatr. 2007;50(7):686-693.   Published online July 15, 2007
Purpose : Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is a potent inhibitor of inosine-monophosphate dehydrogenase (IMPDH), a new immunosuppressive drug used. It was reported that MPA protected neurons after excitotoxic injury, induced apoptosis in microglial cells. However, the effects of MPA on hypoxic-ischemic (HI) brain injury has not been yet evaluated. Therefore, we examined whether MPA...
Case Reports
A familial case report of paroxysmal kinesigenic dyskinesia in three brothers
Oh Dae Kwon, Sung Jin Hwang, Jun Hwa Lee, Ji Eun Kim, Kyung Jib Kim, Eul Ju Seo
Korean J Pediatr. 2007;50(7):694-697.   Published online July 15, 2007
Paroxysmal kinesigenic dyskinesia (PKD), previously referred to as movement-provoked seizures, is a rare neurological condition that is characterized by short duration dystonic or choreoathetotic movements precipitated by sudden movement, a change in position or hyperventilation. It can be difficult to distinguish this syndrome from seizures. We reported on three brothers in one family all of whom developed abnormal involuntary dystonic...
Two cases of Chryseobacterium meningosepticum infection in a neonatal intensive care unit
Hye Sun Yoon
Korean J Pediatr. 2007;50(7):698-701.   Published online July 15, 2007
We report on two premature infants who developed nosocomial infection caused by Chryseobacterium meningosepticum in a neonatal intensive care unit (NICU). One premature infant developed sepsis, meningitis, and hydrocephalus, and was treated successfully with ciprofloxacin plus trimethoprim-sulfamethoxazole combination therapy for 4 weeks and with a ventriculoperitoneal shunt. The other premature infant, who was in a chronically debilitated state, had infection...
Erratums
Choi Han-Woong: Comment on Cortisone therapy in pediatric fields (Soakwa 1958;1:19-23)
Korean J Pediatr. 2007;50(7):702.   Published online July 15, 2007
Kim Young-Taek: Comment on acute pyelonephritis (Soakwa 1958;1:1-11)
Korean J Pediatr. 2007;50(7):703.   Published online July 15, 2007
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