Most cited
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most cited
Most-cited articles are from the articles published during the last two years (2022 ~ ).
- Editorial
- Infection
- Impact and role of vitamins as immunonutrition in children during COVID-19 pandemic
-
Yoo Min Lee
-
Clin Exp Pediatr. 2023;66(5):212-214. Published online April 18, 2023
-
|
· Vitamins have effector mechanisms in the innate and adaptive immune systems and potential roles in preventing and reducing the severity of coronavirus disease 2019 (COVID-19).
· Vitamins may be immunonutrients in the treatment of COVID-19 infections and prevention of patient deterioration due to critical illness, thus demonstrating the significance of a nutritious, well-balanced diet. |
-
-
- Original Article
- Infection
- Clinical characteristics of pediatric patients infected with SARS-CoV-2 versus common human coronaviruses: a national multicenter study
-
In Suk Sol, Eun Lee, Hyeon-Jong Yang, Yong Ju Lee, Hye Yung Yum, Mi-Hee Lee, Mi Ae Chu, Hui Jeong Moon, Hyo-Bin Kim, Ju Hee Seo, Jung Yeon Shim, Ji Young Ahn, Yoon Young Jang, Hai Lee Chung, Eun Hee Chung, Kyunghoon Kim, Bong-Seong Kim, Cheol Hong Kim, Yang Park, Meeyong Shin, Kyung Suk Lee, Man Yong Han, Soo-Jong Hong, Eun Kyeong Kang, Chang Keun Kim; on behalf of The Pneumonia & Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease
-
Clin Exp Pediatr. 2023;66(3):134-141. Published online December 22, 2022
-
|
Question: The clinical differences between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and human coronaviruses (HCoV) in children remain unknown.
Finding: This study compared the clinical findings of children infected with SARS-CoV-2 versus HCoV. Its findings suggest that children and adolescents with SARS-CoV-2 have a milder clinical course than those with HCoV.
Meaning: The clinical course of children and adolescents with SARS-CoV-2 should be closely monitored during the coronavirus disease 2019 pandemic. |
-
-
- Original Article
- Hematology
- Changes and correlations of T-cell coinhibitory molecule programmed death-1 and interferon-γ in pediatric immune thrombocytopenia
-
Fady Mohamed El-Gendy, Amira M.F. Shehata, Esam Awad Abd El-Kawy, Mahmoud Ahmed El-Hawy
-
Clin Exp Pediatr. 2023;66(3):127-133. Published online February 24, 2023
-
|
Question: What are the PD-1+ CD4+ T cells percentages and serum interferon gamma (IFN-γ) levels of pediatric patients with immune thrombocytopenia (ITP)?
Finding: Compared with healthy controls, the PD-1+ CD4+ T cells percentages and IFN-γ levels were significantly higher in ITP patients before and 1 month after therapy.
Meaning: Our findings suggest that PD-1+ CD4+ T cells and IFN-γ are involved in the pathophysiological process of ITP. |
-
-
- Editorial
- Emergency Medicine
- Current diagnosis and image-guided reduction for intussusception in children: teamwork approach
-
Ji-Hyun Seo
-
Clin Exp Pediatr. 2023;66(2):66-67. Published online September 1, 2022
-
|
|
· The successful and safe enema reduction of intussusception depends primarily on the experience and preference of the radiologists and the availability of resources.
· The establishment of a standardized manual or protocol for reduction and pre-reduction treatment of intussusception, along with the collaboration of pediatricians, radiologists, and surgeons, is expected to improve the treatment success rate. |
-
-
- Original Article
- Gastroenterology
- Association between maternal weight gain during pregnancy and child’s body mass index at preschool age
-
Jeewon Shin, Yoowon Kwon, Ju Hee Kim, Su Jin Jeong
-
Clin Exp Pediatr. 2023;66(2):76-81. Published online November 30, 2022
-
|
Question: What are the risk factors of newborn birth weight? Does gestational weight gain and prepregnancy body mass index affect childhood weight?
Finding: Excess maternal weight gain increases the risk of overweight/obesity, newborn birth weight, and child body mass index at 4–6 years.
Meaning: Maternal weight control before and during pregnancy should be well controlled. |
-
-
- Developmental and Behavioral Medicine
- Attention-deficit/hyperactive-impulsive disorder symptoms among grade 1 students with reading disorder in Thailand
-
Patcharapun Sarisuta, Issarapa Chunsuwan, Tippawan Hansakunachai, Paskorn Sritipsukho
-
Clin Exp Pediatr. 2023;66(11):485-492. Published online October 24, 2023
-
|
Question: Would students with reading disorder have a significantly higher prevalence of attention-deficit/hyperactiveimpulsive disorder (ADHD) symptoms than neurotypical students?
Finding: Students at risk of reading disorder exhibited significant ADHD symptoms compared with those not at risk of reading disorder according to all presentations of teacher assessments versus only for predominantly inattentive presentations of the parental assessments.
Meaning: Students with reading disorder have a significantly higher prevalence of ADHD symptoms than neurotypical students. Sex, parental education level, average family income, and children’s school affiliation significantly influenced reading disorder prevalence. |
-
-
- Neonatal risk factors associated with attention-deficit/hyperactivity disorder: an umbrella review
-
Ensiyeh Jenabi, Erfan Ayubi, Sajjad Farashi, Saeid Bashirian, Fereshteh Mehri
-
Clin Exp Pediatr. 2023;66(10):441-446. Published online July 14, 2023
-
|
Question: The risk factors for attention deficit hyperactivity disorder (ADHD), such as breastfeeding, congenital heart disease, and low birth weight, in neonates are not well understood.
Finding: This umbrella review obtained significant effect sizes for ADHD for congenital heart disease (odds ratio [OR], 3.04), low birth weight (OR, 2.25), never breastfed (OR, 1.55), and Apgar score (OR, 1.30).
Meaning: Congenital heart disease, low birth weight, lack of breastfeeding, and Apgar scores were significant factors for ADHD. |
-
-
- Impact of short and intensive art-based intervention on symptomatology and social interactions among children with autism spectrum disorder
-
Deldar Morad Abdulah, Bayar Mohammed Omar Abdulla, Pranee Liamputtong
-
Clin Exp Pediatr. 2023;66(10):447-454. Published online September 14, 2023
-
|
Question: Does a short and intensive art-based intervention affect symptoms and social interactions among children with autism spectrum disorder (ASD)?
Finding: The short and intensive art-based intervention did not affect symptoms in children with ASD level 2 or 3, including social awareness, social cognition, social communication, social motivation, and autistic mannerisms.
Meaning: The short and intensive art-based intervention did not improve the symptoms of patients with ASD. |
-
-
- Original Article
- Neonatology (Perinatology)
- A thickened formula reduces feeding-associated oxygen desaturation and bradycardia in preterm infants
-
Gayoung Lee, Juyoung Lee, Ga Won Jeon, Yong Hoon Jun
-
Clin Exp Pediatr. 2023;66(1):32-37. Published online December 15, 2022
-
|
Question: Is a commercial thickened formula able to alleviate oral feeding-associated desaturation and bradycardia in preterm infants?
Finding: Thickened formula feeding significantly reduced oral feeding-associated desaturation and bradycardia in preterm infants.
Meaning: Thickened formula feeding stabilizes oxygen saturation and heart rate during oral feeding among preterm infants with feeding difficulties. |
-
-
- Editorial
- Cardiology
- Characteristics of z score systems for diagnosing coronary abnormalities in Kawasaki disease
-
Gyeong-Hee Yoo
-
Clin Exp Pediatr. 2022;65(9):448-449. Published online March 14, 2022
-
|
Because of the various body sizes of children with Kawasaki disease (KD), coronary artery diameter requires normalization to the body surface area as a z score.
In updated guidelines, coronary artery abnormalities are important criteria in the diagnosis of KD, and z score systems have been accepted to define coronary artery abnormalities.
However, the z score formula should be selected carefully because each yields different results. |
-
-
- Original Article
- Hematology
- Effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major: a single-center study
-
Mahmoud A. El-Hawy, Nagwan Y. Saleh
-
Clin Exp Pediatr. 2022;65(8):405-409. Published online June 7, 2022
-
|
Question: What is the effect of cyclic pamidronate administration on osteoporosis in children with β-thalassemia major?
Finding: The dual-energy x-ray absorptiometry scan findings of children with β-thalassemia major and osteoporosis were improved after pamidronate administration.
Meaning: Cyclic pamidronate effectively treated osteoporosis in children with β-thalassemia major. |
-
-
- Editorial
- Cardiology
- Coronavirus disease 2019 and mRNA vaccines: what’s next – miRNA?
-
Joon Kee Lee, Heon-Seok Han
-
Clin Exp Pediatr. 2022;65(6):302-303. Published online March 28, 2022
-
|
|
MicroRNAs (miRNAs) are small single-stranded noncoding RNA molecules that function in RNA silencing and the posttranscriptional regulation of gene expression. The potential role of miRNAs as biomarkers of myocarditis is promising, and miRNAs are expected to be utilized in various clinical fields in the future. |
-
-
- Infection
- Effects of nonpharmaceutical interventions for coronavirus disease 2019
-
Jae Hong Choi
-
Clin Exp Pediatr. 2022;65(5):250-251. Published online March 22, 2022
-
|
|
∙ Nonpharmaceutical interventions (NPIs) have decreased the incidence of various infectious diseases, including coronavirus disease 2019 (COVID-19).
∙ During the 2-year COVID-19 pandemic, NPIs changed patients’ daily lives, and the impact on mental health was notable.
∙ The effects of NPIs were evaluated in detail, considering both infections and mental health. |
-
-
- Endocrinology
- Is type 1 diabetes related to coronavirus disease 2019 in children?
-
Minsun Kim
-
Clin Exp Pediatr. 2022;65(5):252-253. Published online March 29, 2022
-
|
|
· Evidence shows that patients with type 1 diabetes have been severely affected by coronavirus disease 2019 (COVID-19) in various ways.
· Although there is no reliable evidence that COVID-19 worsens or induces diabetes, it can impair β-cell insulin secretion and glucose control by inducing inflammation and cytokine production.
· A study is needed of the short- and long-term relationship between diabetes and COVID-19 in the Korean pediatric population. |
-
-
- Original Article
- Emergency Medicine
- Nonfatal injuries in Korean children and adolescents, 2007–2018
-
Gyu Min Yeon, Yoo Rha Hong, Seom Gim Kong
-
Clin Exp Pediatr. 2022;65(4):194-200. Published online September 9, 2021
-
|
Question: How many children and adolescents have experienced nonfatal injuries in the previous year?
Finding: Among Korean children and adolescents, 8.1% experienced at least one injury per year. We found no significant change in the incidence of injuries over the previous 12 years.
Meaning: The incidence of injuries is higher than this estimation; therefore, more attention and effort are needed to prevent injuries among children and adolescents. |
-
-
- Neonatology (Perinatology)
- Is fetal nuchal cord associated with autism spectrum disorder? A meta-analysis
-
Ensiyeh Jenabi, Maryam Ahmadi, Azam Maleki
-
Clin Exp Pediatr. 2022;65(3):131-135. Published online September 24, 2021
-
|
Question: Is fetal nuchal cord a risk factor for autism spectrum disorder (ASD)?
Finding: Five articles (1 cohort, 4 case-control; total 3,088 children) were included in the present meta-analysis. Fetal nuchal cord was not a risk factor for ASD (odds ratio, 1.11; 95% confidence interval, 0.66–1.57). There was homogeneity among studies that reported a risk of ASD (I2=0.0).
Meaning: Fetal nuchal cord is not a risk factor for ASD. |
-
-
- Editorial
- Infection
- Importance of maintaining a high childhood vaccination rate and surveillance program against Japanese encephalitis in Korea
-
Su Eun Park
-
Clin Exp Pediatr. 2022;65(3):127-128. Published online February 16, 2022
-
|
∙ Recent epidemiologic changes of Japanese encephalitis (JE) in Korea are area (rural to urban or suburban) and age shift (children to adult).
∙ Although the main factors contributing to recent epidemiologic changes of JE are not well identified, maintaining high vaccination rates of JE appear to be important in preventing of JE in all age groups.
∙ Continuous surveillance for epidemiology and seroprevalence should be carried out. |
-
-
- Review Article
- General Pediatrics
- A new perspective on cholesterol in pediatric health: association of vitamin D metabolism, respiratory diseases, and mental health problems
-
Jeana Hong
-
Clin Exp Pediatr. 2022;65(2):65-72. Published online December 9, 2021
-
|
∙ Pediatric dyslipidemia is associated with several health problems besides cardiovascular diseases.
∙ There is a direct association between pediatric dyslipidemia and low serum vitamin D levels, asthma, and mental health problems regardless of body mass index.
∙ More large-scale nationally representative studies are needed to establish the appropriate cutoff points for the definition of dyslipidemia that is a prerequisite for further epidemiological studies in the Korean pediatric population. |
-
-
- Editorial
- Neurology
- Cerebrospinal fluid biomarkers in various pediatric neurologic diseases
-
Jeongho Lee
-
Clin Exp Pediatr. 2022;65(2):81-82. Published online January 6, 2022
-
|
Cerebrospinal fluid (CSF) has many important biomarkers that are commonly analyzed in pediatric neurologic diseases, including central nervous system infection and inflammation. Neurologic disease in pediatrics is difficult to diagnosis, there are challenges in developing CSF profiles. Some biomarkers are expected to help differential diagnosis. |
-
-
- Original Article
- Cardiology
- Vasovagal syncope with mild versus moderate autonomic dysfunction: a 13-year single-center experience
-
Han Eoul Lee, Dong Won Lee
-
Clin Exp Pediatr. 2022;65(1):47-52. Published online June 1, 2021
-
|
Question: It is well known that autonomic dysfunction contributes to vasovagal syncope (VVS). Does the degree of autonomic dysfunction contribute to clinical manifestations, diagnostic methods, treatment, and prognosis?
Finding: The clinical manifestations, diagnostic methods, treatment, and prognosis differ between patients with mild and moderate degrees of autonomic dysfunction.
Meaning: VVS is caused by autonomic dysfunction, but autonomic dysfunction severity need not be classified. |
-
-
- Letter to the Editor
- Other
- Evaluation of simulation-based ultrasound course for pediatricians: a starting point for future training curriculum
-
Chon In Kuok, Avis Siu Ha Leung, Jonan Chun Yin Lee, Winnie Kwai Yu Chan
-
Clin Exp Pediatr. 2022;65(1):53-55. Published online July 28, 2021
-
|
Question: Simulation-based ultrasound training is becoming more popular. Is there a role for pediatricians in such training programs?
Finding: Our program received promising feedback from its participants. Self-rated confidence in image interpretation and ultrasound-guided catheter insertion improved after the simulation. Participants reported a higher preference for performing ultrasound scans before radiologist assessment.
Meaning: Ultrasound training can be considered as part of the pediatric training curriculum in the future. |
-
-
- Editorial
- General Pediatrics
- Is it time to add point-of-care ultrasound education to pediatric residency curriculum?
-
Shin Ae Yoon
-
Clin Exp Pediatr. 2022;65(1):33-34. Published online October 12, 2021
-
|
|
Growing point-of-care ultrasound (POCUS) use in pediatric patients has led to the need for POCUS education for pediatric residents. Recent experimental studies have suggested that POCUS education improves self-rated POCUS confidence and comfort in pediatric resident training. Considering the effective and sustainable POCUS education curriculum in pediatric resident training, simulation-based education would be a solution. |
-
-
