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Original Article

Interaction of the mec Regulator Genes in Methicillin Resistant Staphylococcus

Young Choi, In Seok Lim, Tae Sub Shim, Mi Kyung Lee, Ae Ja Park

Clin Exp Pediatr. 1998;41(9):1224-1233. Published online September 15, 1998

Purpose : Low-affinity penicillin-binding protein PBP 2a encoded by mecA is closely related to methicillin resistance in staphylococci, and the expression of PBP 2a is controlled by regulator elements encoded by mecR1 and mecI. Deletion or mutation which occurred in mecI is considered to be associated with constitutive production of PBP 2a. We investigated the distribution of mec regulator genes...

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