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Review Article
Practical Concepts and strategies for early diagnosis and management of eosinophilic gastrointestinal disorders in East-Asian children
Byung-Ho Choe
Eosinophilic gastrointestinal disorders (EGIDs) are emerging as significant concerns in the Korean pediatric population and transitioning from rare to more commonly diagnosed conditions. This review discusses the increasing prevalence of EGID among children and adolescents and highlights the complexities involved in its diagnosis and management. This review begins with a thorough examination of the diverse clinical presentations of EGIDs in...
Editorial
Gastroenterology
Strategies for treating and managing chronic hepatitis C in children in the direct-acting antiviral era
Suk-Jin Hong, Byung-Ho Choe
Clin Exp Pediatr. 2020;63(2):46-47.   Published online February 6, 2020
Original Article
Nephrology (Genitourinary)
Renal involvement in children and adolescents with inflammatory bowel disease
Hea Min Jang, Hee Sun Baek, Jung-Eun Kim, Ju Young Kim, Yeon Hee Lee, Hee Yeon Cho, Yon Ho Choe, Ben Kang, Byung-Ho Choe, Bong Seok Choi, Min Hyun Cho
Clin Exp Pediatr. 2018;61(10):327-331.   Published online September 12, 2018

Purpose: The incidence of inflammatory bowel disease (IBD) is rapidly increasing, and several reports have described the renal complications of IBD. We sought to evaluate the clinical manifestations of renal complications in children with IBD in order to enable early detection and prompt treatment of the complications. Methods: We retrospectively reviewed the medical records of 456 children and adolescents aged <20...
Clinical experience with amitriptyline for management of children with cyclic vomiting syndrome
Ye Jee Shim, Jung-mi Kim, Soonhak Kwon, Byung-Ho Choe
Clin Exp Pediatr. 2009;52(5):538-543.   Published online May 15, 2009
Purpose : To report the clinical experience with amitriptyline for managing children with cyclic vomiting syndrome (CVS). Methods : Totally, eleven children (eight males) were diagnosed with CVS. Of these, medical records were reviewed for eight children treated with amitriptyline; three children were not treated because one was not followed up and two were kept under observation to study the...
The effect of erythropoietin in neonatal rat model of hypoxic-ischemic brain injury
Heng-Mi Kim, Byung-Ho Choe, Soon-Hak Kwon, Yoon-Kyung Sohn
Clin Exp Pediatr. 2009;52(1):105-110.   Published online January 15, 2009
Purpose : Perinatal asphyxia is an important cause of neonatal mortality and subsequent lifelong neurodevelopmental handicaps. Although many treatment strategies have been tested, there is currently no clinically effective treatment to prevent or reduce the harmful effects of hypoxia and ischemia in humans. Erythropoietin (Epo) has been shown to exert neuroprotective effects in various brain injury models although the exact...
Review Article
The epidemiology and present status of chronic hepatitis B in Korean children
Byung-Ho Choe
Clin Exp Pediatr. 2008;51(7):696-703.   Published online July 15, 2008
Korea is now classified as an area of intermediate endemicity for hepatitis B virus (HBV), due to the implementation of universal HBV vaccination and national preventive programs for HBV infection. A national program of HBV vaccination was launched in Korea in 1988 for school-going children and was listed on a vaccination guideline in 1991. In 1995, universal vaccination for newborn...
The management and treatment of chronic hepatitis B in Korean children
Byung-Ho Choe
Clin Exp Pediatr. 2007;50(9):823-834.   Published online September 15, 2007
Interferon (IFN) alpha has been the first line therapy of chronic hepatitis B in children, but HBeAg seroconversion occurred in 26% of treated children compared to 11% of controls in multinational randomized controlled study. Recently, lamivudine was shown to be a potent inhibitor of Hepatitis B virus (HBV) reproduction both in HBeAg positive and in HBeAg negative (the pre-core mutant...
Original Article
Comparison of Therapeutic Efficacy between Lamivudine and Alpha-Interferon in Korean Children with Chronic Hepatitis B at Two Years after the Initiation of Treatment
Byung-Ho Choe, You Cheol Jang, Chang Hwan Jang, Ki Won Oh, Jun Hwa Lee, Cheol Woo Ko
Clin Exp Pediatr. 2005;48(1):55-62.   Published online January 15, 2005
Purpose : We compared the therapeutic efficacy of lamivudine and alpha-interferon in children with chronic hepatitis B two years after the initiation of treatment, so that we could verify the safety and long term efficacy of lamivudine in children. Methods : We prospectively studied 44 children(32 male and 12 female; age, 1-18 years, mean, 9 years) treated for chronic hepatitis B...
Medical Lecture Course
The Possibility of the 'Cure' for Liver Diseases by Hepatocyte Transplantation and Hepatocyte based Gene Therapy
Byung-Ho Choe
Clin Exp Pediatr. 2002;45(11):1317-1324.   Published online November 15, 2002
Case Report
A Case of Ornithine Transcarbamylase(OTC) Deficiency
Soonhak Kwon, Yejhin Lee, Byung-Ho Choe, Sangkwon Lee
Clin Exp Pediatr. 2000;43(1):123-127.   Published online January 15, 2000
OTC deficiency is an X-linked disorder in which the synthesis of urea is impaired. OTC catalyzes the synthesis of citrulline from carbamyl phosphate and ornithine. Complete or partial deficiencies of this enzyme may lead to Reye syndrome like picture such as encephalopathy, hepatic dysfunction, hyperammonemia, etc. We recently had a case that was presented as recurrent Reye syndrome, and was...
Original Article
A Catalogue of Gene Expression Difference in Biliary Cirrhosis due to Biliary Atresia Using Differential Expressed Sequence Tags(EST) Screening
Byung-Ho Choe, Hyun-Mi Lee, Moon-Kyu Kim, Jung-Chul Kim
Clin Exp Pediatr. 2000;43(1):60-69.   Published online January 15, 2000
Purpose : Extrahepatic biliary atresia is the most common indication for liver transplantation in children, but the etiology of this disorders remains unknown. It would be very signficant to identify genes that are specifically expressed in pathologic liver tissue of biliary atresia and analyze the pattern of expression in those genes. Methods : We made dot blot panels consisting of 1,730 different EST(expressed sequence...