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Original Article
Combined chemotherapy and intra-arterial chemotherapy of retinoblastoma
Saerom Choi, Jung Woo Han, Hyosun Kim, Beom Sik Kim, Dong Joon Kim, Sung Chul Lee, Chuhl Joo Lyu
Clin Exp Pediatr. 2013;56(6):254-259.   Published online June 21, 2013
Purpose

Retinoblastoma (RB) is the most common primary malignant intraocular tumor in children. Although systemic chemotherapy has been the primary treatment, intra-arterial chemotherapy (IAC) represents a new treatment option. Here, we performed alternate systemic chemotherapy and IAC and retrospectively reviewed the efficacy and safety of this approach.

Methods

Patients diagnosed with intraocular RB between January 2000 and December 2011 at Severance Children's Hospital,...

Weaning food practice in children with iron deficiency anemia
Joo Hee Chang, Woo Sik Cheong, Yong Hoon Jun, Soon Ki Kim, Hung Sik Kim, Sang Kyu Park, Kyung Ha Ryu, Eun Sun Yoo, Chuhl Joo Lyu, Kun soo Lee, Kwang Chul Lee, Jae Young Lim, Du Young Choi, Byung Kyu Choe, Eun Jin Choi, Bong Soon Choi
Clin Exp Pediatr. 2009;52(2):159-166.   Published online February 15, 2009
Purpose : Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies in children on a weaning diet. We investigated weaning practices in infants and children, as well as their mothers' knowledge about weaning. Methods : We investigated 129 children with IDA and 166 without IDA (aged 6-36 months) who had visited 10 university hospitals between March 2006...
Clinical characteristics and prognostic factors for survival in hemophagocytic lymphohistiocytosis
Khi Joo Kim, Ki Hwan Kim, Taek Jin Lee, Jin-Kyong Chun, Chuhl Joo Lyu, Dong Soo Kim
Clin Exp Pediatr. 2008;51(3):299-306.   Published online March 15, 2008
Purpose : Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH. Methods : We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from...
Follow-up Studies and Clinical Significance of Chromosomal Rearrangement in Childhood Acute Lymphocytic Leukemia
Yang Hyun Kim, Jung Tae Kim, Jung Chul Kang, Hae Sik Kwon, Sung Chul Won, Seung Hwan Oh, Chuhl Joo Lyu
Clin Exp Pediatr. 2004;47(8):861-867.   Published online August 15, 2004
Purpose : Through routine screening for chromosomal defects present in patients with acute lymphocytic leukemia(ALL) by means of reverse transcription-polymerase chain reaction(RT-PCR), we aimed for earlier detection of recurrences, hence evaluating the progress of the disease after treatment, and forecasting the need for further testing. Methods : We analyzed 30 patients who visited the Pediatrics Department of Severance Hospital, from...
Effect of Delayed Intensification on Survival of Childhood Acute Lymphoblastic Leukemia
Jie Yeon Lee, Sue Youn, Byoung Chul Kwon, Chuhl Joo Lyu, Hwang Min Kim
Clin Exp Pediatr. 2003;46(12):1260-1265.   Published online December 15, 2003
Purpose : In 1970, the Berlin-Frankfurt-Munster(BFM) group introduced an intensification therapy after remission induction to reduce relapse of acute lymphoblastic leukemia(ALL) in childhood. Delayed intensification(DI) phase has been included for treatment of ALL in our hospital since the mid-1990s. The purpose of this study is to evaluate the outcome with vs. without DI phase and the outcome with two vs....
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
Clin Exp Pediatr. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
Case Report
A Case of Subcutaneous Panniculitis-like T Cell Lymphoma in Childhood
Yoon Seok Choi, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Byung Soo Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(8):1028-1032.   Published online August 15, 2002
Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical...
A Successful Transplant of HLA-3 Loci Mismatched Umbilical Cord Blood into a Patient with Acute Myeloid Leukemia from an Unrelated Donor
Byoung Chul Kwon, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Hyun Ok Kim
Clin Exp Pediatr. 2002;45(7):912-916.   Published online July 15, 2002
Cord blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution. The number of umbilical cord blood transplants is increasing worldwide. In this a case 15- month-old boy with acute myeloid leukemia was treated with umbilical cord blood transplant from an HLA-3 loci mismatched unrelated donor. Granulocyte recovery greater than 500/mm3 occurred at day 49, and...
A Case of Wilms Tumor with Thrombi which Invaded the Right Ventricule
Ji Hyun Uhm, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Byung Soo Kim, Eui Ho Hwang, Young Hwan Park, Chang Ok Seo
Clin Exp Pediatr. 2002;45(3):390-394.   Published online March 15, 2002
College of Medicine, Yonsei University, Seoul, Korea Wilms tumor is the second most common malignant retroperitoneal tumor. Inferior vena cava and right atrial involvement is found in about 4-10% and 0.5-3% of cases, respectively. But, right ventricular involvement has not been reported. We experienced a case of Wilms tumor with right ventricular invasion in a 2 year-old male who presented intermittent...
Original Article
Effect of GCV on Neuroblastoma Cell Line Expressed by HSV-TK Gene with Retroviral Vector
Hyun Sang Cho, Chuhl Joo Lyu, Yeun Soo Kim, Tae Soo Kim, Byung Soo Kim
Clin Exp Pediatr. 1997;40(12):1719-1724.   Published online December 15, 1997
Background : Gene transfer with vectors derived from murine retroviruses is restricted to cells which are proliferating and synthesizing DNA at the time of infection. Accordingly, selective introduction of genes encoding for susceptibility to otherwise nontoxic drugs(suicide genes) into proliferating tumor may be used to treat cancer. We investigated the efficacy of in vitro transduction of neuroblastoma cell with the herpes simplex-thymidine kinase(HSV-tk) gene followed...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
Case Report
A Case of Childhood Adenocarcinoma
Mi Jung Park, Moon Sung Psrk, Seunng Hwang Oh, Chuhl Joo Lyu, Ki Sup Chung, Byung Soo Kim
Clin Exp Pediatr. 1994;37(1):109-114.   Published online January 15, 1994
Gastric adenocarcinoma in childhood is an extremely rare disease with poor prognosis. We experienced a case in which a 14 year old female patient who was admitted with complaints of abdominal pain, indigestion and obstipation. Her physical examination revealed positive Blumer's rectal shelf, positive ascitic fluid cytology and typical radiologic and endoscopic findings suggesting gartric adenocarcinoma. She showed symptomatic improvement...
Original Article
A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
Case Report
A Case of Congenital Neuroblastoma: Diagnosed at Antenatal Perio
Hye Young Kang, Chuhl Joo Lyu, Byung Soo Kim, Seung Kang Choi, Woo Hee Jung, Soon Ae Chun
Clin Exp Pediatr. 1992;35(12):1750-1755.   Published online December 15, 1992
Neuroblastoma is one of the most common tumors of childhood. It accounts for about 8% of all pediatric cancers. Because most children who present with this tumor are older than 1 year of age and have advanced disease, they have a poor prognosis in spite of intensive treatment. The patients with less than 1 year of age at the time of...
Neonatal Tetanus Treated with Intermittent Positive-Pressure Ventilation.
Ran Namgung, Chuhl Joo Lyu, Chul Lee, Youn Ha Kang, Dong Gwan Han
Clin Exp Pediatr. 1987;30(6):671-676.   Published online June 30, 1987
We report our experience with Neonatal Tetanus treated with Intermittent Positive-Pressure Ventilation combined with Neuromuscular blockade and high dose diazepam. Duration of mechanical ventilation was ranged from 15 days in case 1 to 36 days in case 2. Pneumonia with atelectasis and sepsis due to pseudomonas cepacia was complicated in case 2, but cleared up with sensitive antibiotics and vigorous physiotherapy. Muscle relaxation and sedation...
Original Article
The Criteria for Surgical Correction of Ventricular Septal Defect by Non-invasive Diagnostic Methods.
Chuhl Joo Lyu, Jun Hee Sul, Sung Kyu Lee, Dong Shik Chin
Clin Exp Pediatr. 1986;29(8):830-835.   Published online August 31, 1986
In selected cases, early corrective surgery is indicated in the management of infants with moderate or large ventricular septal defects. The risks of any surgical procedure in infancy are acknowledged to be great and should be avoided if possible. However, these surgical risks are justified when the patients have intractable congestive heart failure, marked growth retardation, recurrent prolonged lower respiratory...