Clinical and Experimental Pediatrics

Original Article

The Preventive Effect of Dexrazoxane and Pentoxifylline on Adriamycin Induced Cardiomyopathy

Ling Zhu, Eun-Jung Bae, Il-Soo Ha, Jung-Wook Seo, Chung-Il Noh, Jung-Yun Choi, Yong-Soo Yun

Clin Exp Pediatr. 2005;48(12):1378-1384. Published online December 15, 2005

Purpose : We hypothesized dexrazoxane(DXR) and pentoxifylline(PTX) may prevent myocardial damage in adriamycin(ADR)-induced cardiomyopathic rat model. We also investigated their effects on the myocardial apoptosis and fibrosis in ADR induced cardiomyopathy. Methods : The six-week old female Spregue-Dawley rats were divided into control group(CNT, n= 4), ADR group(n=6), ADR＋DXR group(DXR, n=5), ADR＋PTX group(PTX, n=6), ADR＋DXR＋PTX group(DXPT, n=5). ADR(5 mg/week, twice) was...

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Evaluation of Prognostic Factors in Corrected Transposition of the Great Arteries at Mid-term Follow-up

Young-Hwan Song, Hyok-Joo Kwon, Gi-Beom Kim, Soo-Jung Kang, Eun-Jung Bae, Chung-Il Noh, Yong-Soo Yun, Jeong-Ryul Lee, Yong-Jin Kim, Joon-Ryang Rho

Clin Exp Pediatr. 2003;46(2):154-161. Published online February 15, 2003

Purpose : The prognosis of patients with corrected transposition of the great arteries(C-TGA) is variably affected by associated intracardiac defects, systemic right ventricular function, tricuspid valve competence, and conduction disturbances. This study aims to evaluate the importance of those factors at mid-term follow-up. Methods : Medical records of 94 patients(males 58, females 36; mean age at last follow-up, 12? years; mean...

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Autonomic Activity, Cardiac Chaos and Circadian Rhythm in Asymptomatic Children with Postoperative Tetralogy of Fallot

Myung-Kul Yum, Nam-Su Kim, Jae-Won Oh, Chang-Ryul Kim, Chul-Burm Lee, June Huh, Chung-Il Noh

Clin Exp Pediatr. 1998;41(11):1517-1529. Published online November 15, 1998

Purpose : This study aimed to characterize the autonomic and chaotic control of heart rate and circadian rhythm in asymptomatic patients with postoperative tetralogy of Fallot(pTOF). Methods : Twenty-four-hour electrocardiogram recordings were obtained in 30 asymptomatic pTOF patients and in 30 age-and sex-matched controls, aged between 6 and 11 years. The data was digitized and partitioned into sections of 30-...

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