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Original Article
Utility of a forced expiratory flow of 25 to 75 percent as a predictor in children with asthma
Jung Wan Kang, Kyung Won Kim, Eun Soo Kim, Jun Young Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2008;51(3):323-328.   Published online March 15, 2008
Purpose : Asthma is defined as chronic inflammation of the lower small airways, and bronchial hyperreactivity (BHR) is a pathophysiologic feature of asthma. It has been proposed that although there is no direct variable capable of assessing the small airways, a forced expiratory flow of between 25 and 75 percent (FEF25-75) might be considered a more sensitive early marker of...
Mycoplasma pneumoniae-induced production of proasthmatic mediators in airway epithelium
Kyung Won Kim, Byung Chul Lee, Kyung Eun Lee, Eun Soo Kim, Tae Won Song, Mi Yeoun Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2006;49(9):977-982.   Published online September 15, 2006
Purpose : There has been an increasing amount of literature concerning the association between Mycoplasma pneumoniae and asthma pathogenesis. Interleukin(IL)-6 stimulates the differentiation of monocytes, and can promote Th2 differentiation and simultaneously inhibit Th1 polarization. IL-8 is a potent chemoattractant and, it has been suggested, has a role in asthma pathogenesis. Nitric oxide (NO) synthesized by airway epithelium may be...
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(＋49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Clin Exp Pediatr. 2006;49(5):545-551.   Published online May 15, 2006
Purpose : The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(＋49). Methods : The CTLA-4 promoter(-318 T/C) and exon 1(＋49 A/G) polymorphisms were genotyped via restriction fragment...
Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
Clin Exp Pediatr. 2005;48(8):881-885.   Published online August 15, 2005
Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide...