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Original Article
Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line
Sun-Young Kim, Kyung-Yil Lee, Dae-Chul Jeong, Hak-Ki Kim
Clin Exp Pediatr. 2010;53(7):753-758.   Published online July 31, 2010
Purpose

It has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified. We evaluated the relationship between the GC response and p16 expression in a lymphoma cell line.

Methods

We used p16 siRNA transfection to construct p16-inactivated cells by using the B-cell lymphoblast cell line NC-37. We compared glucocorticoid...



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