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Original Article

Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells

Eun Hye Park, Hyo Jung Lee, Soo Yeon Lee, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang

Clin Exp Pediatr. 2009;52(2):213-219. Published online February 15, 2009

Purpose : Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and detoxification. Iron is also required for neoplastic cell growth due to its catalytic effects on the formation of hydroxyl radicals, suppression of host defense cell activities, and promotion of...

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