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Intrauterine rupture of amnion leading to the development of amnion and/or chorion strand, which encircles developing limbs and adheres to the mouth and other areas of the craniofacies, results in craniofacial and limb defects. The event of amniotic rupture appears to initiate a cascade of secondary defects which may be refered to as Amniotic band anomalad or Amniotic band disruption... |