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Original Article
Expression of Toll-like Receptor-2 on the Peripheral Blood Monocytes in Kawasaki Disease Patients
Dae Hwan Hwang, Jung Woo Han, Kyung Min Choi, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2005;48(3):315-320.   Published online March 15, 2005
Objective : Toll like receptor(TLR) is known to be involved in innate immunity. Many microbial antigens stimulate TLR, and as a result of intracellular signal transduction, they activate nuclear factor-kB which produces diverse inflammtory cytokines. Until now, many research topics in Kawasaki disease focused on cytokine increasement. In this study, we aim to reveal TLR increasement which might be associated...
Effect of Histone H1 on Collagen Induced Arthritis in Mice
Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2004;47(7):779-788.   Published online July 15, 2004
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,...
Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
Clin Exp Pediatr. 2004;47(6):677-684.   Published online June 15, 2004
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies...
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
Clin Exp Pediatr. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
Case Report
A Case of Subcutaneous Panniculitis-like T Cell Lymphoma in Childhood
Yoon Seok Choi, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Byung Soo Kim, Moon Kyu Kim
Clin Exp Pediatr. 2002;45(8):1028-1032.   Published online August 15, 2002
Subcutaneous pannicultis-like T cell lymphoma is a rare cutaneous T cell lymphoma. It presents with multiple subcutaneous nodules or plaques involving the extremities or trunk, and with constitutional symptoms that include fever, malaise, fatigue, myalgia, chills and weight loss. Histologically, the lesions of this disease are reminiscent of panniculitis and are composed of a mixture of small and large atypical...
A Successful Transplant of HLA-3 Loci Mismatched Umbilical Cord Blood into a Patient with Acute Myeloid Leukemia from an Unrelated Donor
Byoung Chul Kwon, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Hyun Ok Kim
Clin Exp Pediatr. 2002;45(7):912-916.   Published online July 15, 2002
Cord blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution. The number of umbilical cord blood transplants is increasing worldwide. In this a case 15- month-old boy with acute myeloid leukemia was treated with umbilical cord blood transplant from an HLA-3 loci mismatched unrelated donor. Granulocyte recovery greater than 500/mm3 occurred at day 49, and...