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Original Article

Changes in MaternalAge and the Incidence of Down Syndrome

Chang Weon Oh, Sung Su Lim, Ki Bok Kim, Won Jin Kee

Clin Exp Pediatr. 1996;39(11):1512-1519. Published online November 15, 1996

Purpose : The incidence of Down syndrome, the most common chromosoaml anomaly, increases with the advanced maternal age. Recently, however, the incidence of Down symdrome was reported to have decreased with wide acceptance of prenatal diagnosis and planned parenthood, prompting us to re-evaluate the incidence of Down syndrome in relation to changes in maternal age. Methods : Subjected to study were 296 Down cases: 26...

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