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Original Article

The Immunohistochemical Expression of Neuronal Nitric Oxide Synthase in Rat Hippocampus after Pentylenetetrazole-Induced Seizures

Doo-Kwun Kim, Tae-Jung Jang

Clin Exp Pediatr. 2001;44(12):1432-1440. Published online December 15, 2001

Purpose : In order to determine the effect of neuronal nitric oxide synthase(nNOS) in seizure-related neuronal vulnerability of the hippocampus, the expression patterns of nNOS were examined in pentylenetetrazole(PTZ)-induced seizure groups and in PTZ seizure groups which were pretreated with nNOS inhibitors. Methods : Male Sprague-Dawley rats weighing 200-300 g were used in PTZ(40 mg/kg)-induced seizure experiments. A specific inhibitor, 50 mg/kg 7-nitroindazole(7-NI), and a...

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