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Case Report

A Case Report of the Letterer-Siwe Disease

Y.J. Choi, S.W. Ahn, E.S. Chang, K.P. Choi, Y.K. Chun, M.H. Huh

Clin Exp Pediatr. 1970;13(12):701-708. Published online December 31, 1970

A case of Letterer-Siwe disease in 1 4/12 year old boy manifesting all of the classic signs described by Siwe-hepatosplenomegaly, swelling of the lymph nodes, bleeding tendency, hypochromic anemia, fever and osseous lesions is presented. The diagnosis was confirmed by skin and lymph node biopsies and radiological evidence of bony defects in the skull and vertebrae. Brief review and discussion...

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