Clinical and Experimental Pediatrics

Original Article

Infection

Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study

Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye

Clin Exp Pediatr. 2025;68(2):153-162. Published online November 11, 2024

· The mortality rate of acute necrotizing encephalopathy was high.
· Laboratory tests revealed that the fatal group had higher creatinine, lactate, activated partial thromboplastin time, thrombin time, interleukin (IL)-6, IL-10, creatine kinase, and D-dimer than survivors.
· The fatal group displayed lower Glasgow Coma Scale scores and arterial pH.

DOI: https://doi.org/10.3345/cep.2024.00794

Clinical outcome of acute necrotizing encephalopathy in related to involving the brain stem of single institution in Korea

Cha Gon Lee, Ji Hye Kim, Munhyang Lee, Jeehun Lee

Clin Exp Pediatr. 2014;57(6):264-270. Published online June 30, 2014

Crossref 21

Purpose

Acute necrotizing encephalopathy (ANE) is a fulminant disease of the brain characterized by bilateral thalamic lesions, and is prevalent among children in East Asia. The prognosis of ANE is usually poor with a high mortality rate and neurological sequelae. This study aimed to delineate the clinical characteristics and prognostic factors of ANE.

Methods

We retrospectively analyzed clinical data of 399 pediatric patients...

DOI: https://doi.org/10.3345/kjp.2014.57.6.264

Case Report

A case of acute necrotizing encephalopathy associated with parainfluenza virus infection

Yoo-Na Kim, Su Jeong You

Clin Exp Pediatr. 2012;55(4):147-150. Published online April 30, 2012

Crossref 13

Acute necrotizing encephalopathy (ANE) may be suspected when a young child presents with abrupt onset of altered mental status, seizures, or both. Definitive clinical diagnosis is based on magnetic resonance imaging (MRI) results. ANE is associated with influenza virus infections. Preliminary data suggests that up to 25% of ANE patients die, and up to 25% of ANE survivors develop substantial...

DOI: https://doi.org/10.3345/kjp.2012.55.4.147

Two Cases of Leigh Disease

Seong Hun Kim, Soo En Park, Ju Seok Lee, Sang Ook Nam, Yeong Tak Lim

Clin Exp Pediatr. 1998;41(3):405-409. Published online March 15, 1998

Leigh Disease, or subacute necrotizing encephalopathy(SNE), is a degenerative disorder characterized by lesions of the gray and white matter in the bran and spinal cord. The pathogenesis was known as mitochondrial enzyme defect of the respiratory chain system. We experienced 2 cases of Leigh disease. The first case, a seven-month old girl who was presented with weak respiration and failure...

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