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Original Article

Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy

Seung-Ah Baek, Won-Ho Hahn, Byoung-Soo Cho, Sung-Do Kim

Clin Exp Pediatr. 2010;53(2):215-221. Published online February 15, 2010

Purpose : Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA nephropathy (IgAN). Our aim was to investigate the association between single-nucleotide polymorphisms (SNPs) in IL-17 receptor A (IL-17RA) gene and childhood IgAN. Methods : We analyzed the SNPs in the...

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