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Medical Lecture Course
Impact of Host Genetics on Susceptibility and Outcome of Viral Infections
Eun Hwa Choi
Clin Exp Pediatr. 2004;47(8):815-820.   Published online August 15, 2004
The generation of a draft sequence of the human genome has lead to an opportunity to characterize human diversity, including the differences in host response to numerous pathogens. Host responses upon exposure to a pathogen can determine the wide spectrum of illness from subclinical or mild to severe diseases. Host factors, particularly genetic backgrounds, influence the pathogenesis of infectious diseases....
Perinatal Hepatitis B Virus Infection - Viral Factors in the Mechanism of Perinatal Immunoprophylaxis Failure -
Jong-Hyun Kim
Clin Exp Pediatr. 2004;47(2):123-130.   Published online February 15, 2004
Perinatal hepatitis B virus(HBV) infection may occur despite combined immunoprophylaxis with hepatitis B immunoglobulin and vaccines. Although the mechanism of perinatal prophylaxis still has been obscure, it could be due to : in utero infection; host factors as the personal immunological differences of HLA or cytokine gene; viral factors as a high maternal HBV-DNA level or the presence of surface...
Original Article
Study on Hepatitis B Virus Pre-S/S Gene Mutations in Children with Chronic Hepatitis B Infection
Byeong Hee Son, Yeong Hong Park, Woo Yeong Chung
Clin Exp Pediatr. 2001;44(7):741-751.   Published online July 15, 2001
Purpose : Hepatitis B virus(HBV) with various mutations has been reported. The aims of this study were to investigate the frequency and manifestation of HBV pre-S/S mutations in children with chronic hepatitis B infection. Methods : Sera from 17 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Seventeen...
Hepatitis B Virus Pre-S Gene Mutations in Children with Chronic Hepatitis B Infection
Jae Young Kim, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(9):1232-1240.   Published online September 15, 2000
Purpose : The envelope of HBV consists of three polypeptides which are encoded in pre-S/S open reading frame. Three translation initiation sites are present within this pre-S/S open reading frame, i.e. pre-S1, pre-S2, and S, allowing the expression of large, middle and small HBs proteins. The pre-S1 is thought to carry the receptor binding site for viral entry into hepatocyte...
Mutations in Hepatitis B Virus Precore and Core Promotor in Children with Chronic Hepatitis B Infection - Comparison Between Vertical and Non-vertical Transmission -
Jin Kuk Kim, Yeong Hong Park, Woo Yeong Chung, Chul Ho Kim
Clin Exp Pediatr. 2000;43(6):779-791.   Published online June 15, 2000
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 46 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction product of HBV DNA. In this study, the patients were divided...
Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
Clin Exp Pediatr. 1999;42(10):1392-1402.   Published online October 15, 1999
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...
Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
Clin Exp Pediatr. 1998;41(11):1498-1508.   Published online November 15, 1998
Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2...
Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique
Jin Sook Kim, Young Ran Yoon, Mi Kyung Kim, Hye Kyung Han, Mi Ryung Um, Kyung Hoon Choi, Mi Na Lee, In Keol Moon, In Kweon Han
Clin Exp Pediatr. 1994;37(2):231-239.   Published online February 15, 1994
Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase...
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...
A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1991;34(11):1512-1518.   Published online November 30, 1991
We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93...
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...