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Original Article

Effect of Resuscitation with High Concentration Oxygen on a Rat Model of Neonatal Hypoxic-Ischemic Brain Injury

Dong Seok Lee, Su-Hee Kwak, Heng-Mi Kim, Yoon Kyung Sohn

Clin Exp Pediatr. 2001;44(11):1278-1288. Published online November 15, 2001

Purpose : This study was undertaken to determine whether any features of apoptosis would occur in the established model of cerebral hypoxia-ischemia in neonatal rats. It was also undertaken to evaluate the effect of post-insult hyperoxia on hypoxic ischemic cerebral injury. Methods : Seven-day-old neonatal rats underwent unilateral carotid artery dissection followed by 2 hours of hypoxia. To this end...

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