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Neonatology (Perinatology)

Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia

Ga Won Jeon, R. Ann Sheldon, Donna M Ferriero

Clin Exp Pediatr. 2019;62(12):444-449. Published online October 18, 2019

Crossref 9

Background: Sixty percent of infants with severe neonatal hypoxic-ischemic encephalopathy die, while most survivors have permanent disabilities. Treatment for neonatal hypoxic-ischemic encephalopathy is limited to therapeutic hypothermia, but it does not offer complete protection. Here, we investigated whether hypoxia-inducible factor (HIF) promotes cell survival and suggested neuroprotective strategies.
Purpose: HIF-1α-deficient mice have increased brain injury after neonatal hypoxia-ischemia (HI), and the...

DOI: https://doi.org/10.3345/kjp.2019.00850

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