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Case Report

Rifampin Induced Nonresponsiveness to Steroid Therapy in Children with Minimal Change Nephrotic Syndrome .

Hae Il Cheong, Sang Bok Suk, Yong Choi, Kwang Wook Ko

Clin Exp Pediatr. 1984;27(5):506-510. Published online May 31, 1984

We experienced three children with the biopsy proven minimal change nephrotic syndrome who had failed to respond to prednisolone, 60 mg/m2/d for 4 to 9 weeks due to concomittent administration of rifampin. Because rifampin is a known enzyme inducer of the liver like phenobarbital and dilantin which can increase the clearance of the other drugs such as steroid etc., rifampin were...

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