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Review Article
Infection
Recommendation for use of diphtheria and tetanus toxoids and acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate, and hepatitis B vaccine in infants
Hye-Kyung Cho, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Eun Young Cho, Jong Gyun Ahn, Eun Hwa Choi; The Committee on Infectious Diseases of the Korean Pediatric Society
Clin Exp Pediatr. 2021;64(12):602-607.   Published online June 8, 2021
∙ Diphtheria and tetanus toxoids and acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b-hepatitis B (DTaP-IPV-Hib-HepB) was licensed in Korea in April 2020.
∙ DTaP-IPV-Hib-HepB is indicated as a 3-dose primary series for infants aged 2, 4, and 6 months who received the standalone HepB vaccine at birth.
∙ Infants born to HepB surface antigen-positive mothers are currently recommended to be immunized with HepB immunoglobulin at birth and then monovalent HepB vaccine at 0, 1, and 6 months.
Original Article
The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old
Soo Young Lee, Ga Young Kwak, Hye Rin Mok, Jong Hyun Kim, Jae Kyun Hur, Kyung Il Lee, Park Joon Su, Sang Hyuk Ma, Hwang Min Kim, Jin Han Kang
Clin Exp Pediatr. 2008;51(11):1185-1190.   Published online November 15, 2008
Purpose : This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea. Methods : Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007. Diphtheria and tetanus anti-toxoid antibodies in sera were...
The immunogenicity and safety of three-component DTaP vaccine in Korean infants
Jin Han Kang, Jong Hyun Kim, Jung Hyun Lee, Soo Young Lee, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2007;50(4):355-362.   Published online April 15, 2007
Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine (Infanrix ) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy...
Case Report
A Case of Neonatal Tetanus Cured with Neuromuscular Blocking Agent and Ventilatory Support
Hyeon Joo Lee, Ji Young Jeong, Sa Jun Jung, Yong Mook Choi, Chong Woo Bae
Clin Exp Pediatr. 2003;46(2):192-194.   Published online February 15, 2003
A neonate born at 38 gestational weeks was admitted due to generalized tonic-clonic seizure and cyanosis. The neonate was born six days previously at home through normal delivery and the umbilical cord was cut using scissors sterilized in boiling water. The neonate weighed 3,180 g at admission. Physical examination revealed cyanosis, opisthotonus, trismus and reactive muscle spasms. Laboratory exam, brain...
Original Article
The Values of Tetanus Toxoid Specific IgG Immunoglobulins in Children
Young Kwan Kim, Young Mo Son
Clin Exp Pediatr. 1995;38(3):306-310.   Published online March 15, 1995
Purpose : Tetanus toxoid specific IgG titers were measured in 76 cases on children ranging from neonates to 18 yr old adolescents according to the frequency of DPT vaccination. Methods : The Enzyquick tetanus Kit was used to measure tetanus toxoid specific IgG titers by the ELISA method. Results : 1) In infants less than 2 months-olg, the mean tetanus toxoid specific...
Case Report
Neonatal Tetanus Treated with Intermittent Positive-Pressure Ventilation.
Ran Namgung, Chuhl Joo Lyu, Chul Lee, Youn Ha Kang, Dong Gwan Han
Clin Exp Pediatr. 1987;30(6):671-676.   Published online June 30, 1987
We report our experience with Neonatal Tetanus treated with Intermittent Positive-Pressure Ventilation combined with Neuromuscular blockade and high dose diazepam. Duration of mechanical ventilation was ranged from 15 days in case 1 to 36 days in case 2. Pneumonia with atelectasis and sepsis due to pseudomonas cepacia was complicated in case 2, but cleared up with sensitive antibiotics and vigorous physiotherapy. Muscle relaxation and sedation...
Original Article
Specific Immunoglobulin Responses Against Tetanus Toxoid after DPT Vaccination.
Kyung Jin Shin, Sng Nam Chun, Heon Seob Song, Dae Yeal Lee, Jung Soo Kim
Clin Exp Pediatr. 1987;30(6):625-632.   Published online June 30, 1987
DPT vaccination has successfully been applied to the prevention of tetanus infection. Edsall (1949) reported the presence of serum tetanus antitoxin after tetanus toxoid immunization. Gill et al (1983) also demonstrated that the values of tetanus specific IgM were increased on neonates after maternal tetanus toxiod immunization. The present study was performed to define the humoral immune responses after DPT vaccination. Changes of tetanus specific...
The Effect of Antitoxin in Neonatal Tetanus.
Myung Dong Ahn, Tae Joo Whang, Chull Sohn
Clin Exp Pediatr. 1985;28(1):25-32.   Published online January 31, 1985
Mortality rate of Neonatal tetanus was assessed in 198 casss out of 219 patients during 10 years(1970~1979) according to the amounts of administered antitoxin dosages in a prospective and randomized trial. Mortality rate of Neonatal tetanus administered antitoxin 10,000 I.U. averaged 64.2%, whereas that of Neonatal tetanus administered antitoxin 20,000, 40,000, 60,000 and 100,000 I.U. averaged 60.9%, 78.0 c, 57.1% and!...
A Clinical Study on Predisposing Factors of Death on Neonatal Tetanus.
Keon Su Rhee, Young Hun Chung
Clin Exp Pediatr. 1982;25(7):699-707.   Published online July 31, 1982
Total 60 cases of the patients of neonatal tetanus were clinically evaluated who were admitted to the department of Pediatrics, Chungnam National University Hospital from Jan. 1976 to Dec. 1980 to identify the predisposing factors of death. The result were as follows; 1) The annual patients were encountered in 12 cases and the over all mortality was 42.9%. 2) Sex...
A Climical Observation of Tetanus Neonatorum.
Sung Koo Park, Hyang Sook Kim, Dong Hak Shin
Clin Exp Pediatr. 1981;24(4):311-318.   Published online April 15, 1981
Total 48 cases of the patients of neonatal tetanus, who were admitted and evaluated in our pedi dept from JAN. 1970 to Dec. 1975 and from Jan to Dec. 1979, are summerized with following result. 1) The number of patients yearly means were about 6~7 cases and the over all motality was 48.4%. 2) The sex ratio was 2:1(male: female)....
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