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Original Article
Effects of coagulation factor concentrate prophylaxis in moderate and severe hemophilia A patients at a single hemophilia center in Korea
Byung Suk Moon, Jun Seok Choi, Chur Woo You
Clin Exp Pediatr. 2013;56(7):291-297.   Published online July 19, 2013
Purpose

The aim of this study was to investigate prophylactic treatment effects in Korean patients with severe hemophilia A.

Methods

A prospective study of 32 severe hemophilia A patients was conducted with the approval of the Institutional Review Board at the Eulji University Hospital. Two patients received primary prophylaxis; whereas, the other 30 patients were divided into 2 groups-secondary prophylaxis (n=15) and on-demand...

Direct detection of hemophilia B F9 gene mutation using multiplex PCR and conformation sensitive gel electrophoresis
Ki Young Yoo, Hee Jin Kim, Kwang Chul Lee
Clin Exp Pediatr. 2010;53(3):397-407.   Published online March 15, 2010
Purpose : The F9 gene is known to be the causative gene for hemophilia B, but unfortunately the detection rate for restriction fragment length polymorphism-based linkage analysis is only 55.6%. Direct DNA sequencing can detect 98% of mutations, but this alternative procedure is very costly. Here, we conducted multiplex polymerase chain reactions (PCRs) and conformation sensitive gel electrophoresis (CSGE) to...
Case Report
Availability of peripheral inserted central catheters in severe hemophilia patients with inhibitors
Youngshil Park
Clin Exp Pediatr. 2008;51(12):1359-1362.   Published online December 15, 2008
The most effective treatment strategy for patients with hemophilia is replacement therapy with FVIII or FIX concentrates, which usually requires long-term, uncomplicated venous access. However, central venous access device (CVADs, ports) insertion requires inpatient admission and general anesthesia, and presents some problems regarding health insurance coverage. Peripherally inserted central catheters (PICCs) were inserted in two severe hemophilia patients aged 7...
Review Article
Hemophilia
Ki Young Yoo
Clin Exp Pediatr. 2006;49(8):821-829.   Published online August 15, 2006
Hemophilia is the most common coagulation disorder. It has a long history. Hemophilia A is caused by FVIII gene mutation, and hemophilia B by FIX gene mutation. Those genes are located on X chromosome long arm. Bleedings in hemophiliacs predominantly occur in joints and muscles. Because those site are insufficient in tissue factor to induce hemostasis. Among joints knee, ankle...
Original Article
Clinical Characteristics in Hemophilia Patients
Kun Soo Lee, Eun Sook Kim, Jang Soo Seo
Clin Exp Pediatr. 1992;35(11):1501-1508.   Published online November 15, 1992
The clinical characteristics and laboratory data in the twenty six patients of hemophilia diagnosed in the Department of Pediatrics, Kyungpook National University Hospital for 8 years from 1983 were evaluated. The following results were obtained: Twenty one cases (80.7%) were diagnosed as hemophilia A and five cases (19.3%) as hemophilia B. Eleven cases (42.3%) were diagnosed under one year of age and the...
A Clinical Study and Comprehensive Total Care in Hemophilia.
Shin Heh Kang, Chang Hyun Yang, Kir Young Kim
Clin Exp Pediatr. 1988;31(2):202-211.   Published online February 28, 1988
Hemophilia is one of the hereditary coagulation disorders characterized by deficiency in plasma clotting facotrs such as factor VIII and IX. As life long bleeding occurs in hemophiliacs, continous comprehensive total care is required for the patients. After the self therapy, home care program was introduced in the 1970s’ in the United States, there was significant reduction in absentism, hospitalized days, outpatient visits, decrease...
Clinical Studies on 100 Cases of Hemophilia.
Mi Ja Shin, Kwang Wook Ko
Clin Exp Pediatr. 1984;27(9):883-895.   Published online September 30, 1984
A clincal studies were performed on 100 cases of hemophilia who had been visited to O.P.D. of pediatric department and emergency-room of Seoul Red Cross Hospital during 10 years period between July, 1973 and June, 1983. The results were obtained as follows: 1)Nin ty two cases were confirmed as hemophilia A and 8 cases were hemophilia B and. none of...
Clinical Obseervation for Hematologic Disorders in Children.
Eung Sang Choi, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Chang Yoo Hong
Clin Exp Pediatr. 1981;24(3):235-244.   Published online March 15, 1981
Nine hundred and twenty-three cases of hematologic disorders in children who were admi-tted to department of pediatrics, SNUH, from 1955 to Oct. 1980 were analysed. The patients consisted of 624 males and 299 females. The results were as follows; 1.Mean annual percentage of hematologic patients among total admitted patients was 6.8%. 2.The peak age incidence of various hematologic disorders was...