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The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct
beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple
smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man.
The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment... |
