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Original Article

Tumor Vaccine Effect by IL-16 Gene Transfer into Murine Neuroblastoma Model

Hyun-Sang Cho, Chong Young Park

Clin Exp Pediatr. 2001;44(1):68-74. Published online January 15, 2001

Purpose : Interleukin(IL)-16 is a potent chemoattractant factor for CD4＋ T cells, monocytes, and eosinophils. It up-regulates IL-2R on CD4＋ T lymphocytes and regulates the function of antigen presenting cells. We used retrovirus-mediated gene transfer of the human IL-16 gene into the neuro-2a cells, which is the murine neuroblastoma cell lines, to investigate whether locally secreted IL-16 might generate anti-tumor...

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