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Original Article
Endocrinology
Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome
Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon
Clin Exp Pediatr. 2019;62(7):274-280.   Published online December 3, 2018

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children’s Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were...
Short Term Effect of Recombinant Human Growth Hormone Therapy in Children with Chronic Renal Failure
Si-Whan Ko, Dong-Kyu Ji
Clin Exp Pediatr. 1998;41(9):1256-1261.   Published online September 15, 1998
Purpose : Growth retardation is one of the major side effects of chronic renal failure. In this study, the short-term growth promoting effect, effect on the chemical parameters, and probable side effects of growth hormone treatment to child patients with chronic renal failure were examined. Methods : The research sample was 5 child patients diagnosed with chronic renal failure and receiving...
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones.
Jong Jin Seo
Clin Exp Pediatr. 1990;33(8):1104-1110.   Published online August 31, 1990
The pharmacokinetics, acute biological성fccts and safety of yeast-derived recombinant methionyl- hGH (LBD-003), the first biosynthetic hGH in Korea, were studied in 10 healthy young adults who were administered 8 IU/day intramuscularly for four consecutive days. 1) GH levels reached a mean (±SD) peak of 27.5±10.7 ng/ml at 3.4±0.8 hours following the first dose, and other pharmacokinetic parameters of LBD-003 were similar to those reported for pituitary...