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Original Article

Experssion of the NR2A and 2B Subunits of N-Methyl-D-aspartate Receptors in Hypoxic Neonatal Rat Hippocampus

Jong Su Lee, Dong Seok Lee, Jung hyun Park, Il Soo Moon, Bok Hyun Ko, Yong Wook Jung

Clin Exp Pediatr. 2001;44(4):433-442. Published online April 15, 2001

Purpose : The developing brain has been reported to be extremely susceptible to toxicity of ischemia and/or hypoxia during a restriced developmental period. Hippocampal neuronal cell death is a typical type of perinatal hypoxic brain lesion and often coexists with other forms of cerebral hypoxic injuries. In the present study, we examined whether transcriptional changes of NR2A and NR2B subunits...

Histiocytic Medullart Reticuloisis in Children.

Duck Kyu Kim, Jung Hyun Park, Ok Ji Hwang, Ja Ye Kim, Woo Kap Chung, Kye Sook Lee

Clin Exp Pediatr. 1988;31(9):1217-1224. Published online September 30, 1988

Histiocytic medullary reticulosis (HMR) is a clinicopathologic syndrome characterized by its acute onset and relentless progression to death within a few months. Major clinical features are fever, wasting, generalized lymphadenopathy and hepatosplenomegaly. In the terminal stages, Jaundice, purpura, anemia and leukopenia are common. Cardinal pathologic features are diffuse proliferation of atypical, neoplastic, erythrophagocytic histiocytes and their precursors throughout the reticuloen- dothelial system. Here, we present 2...

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