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Original Article

Histiocytic Medullart Reticuloisis in Children.

Duck Kyu Kim, Jung Hyun Park, Ok Ji Hwang, Ja Ye Kim, Woo Kap Chung, Kye Sook Lee

Clin Exp Pediatr. 1988;31(9):1217-1224. Published online September 30, 1988

Histiocytic medullary reticulosis (HMR) is a clinicopathologic syndrome characterized by its acute onset and relentless progression to death within a few months. Major clinical features are fever, wasting, generalized lymphadenopathy and hepatosplenomegaly. In the terminal stages, Jaundice, purpura, anemia and leukopenia are common. Cardinal pathologic features are diffuse proliferation of atypical, neoplastic, erythrophagocytic histiocytes and their precursors throughout the reticuloen- dothelial system. Here, we present 2...

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