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Case Report
A Case of Congenital Nephrotic Syndrome due to Diffuse Mesangial Sclerosis
Jung-Jin Yu, Dong Kyu Jin, Hae Il Cheong, Hyun Soon Lee, Yong Choi
Clin Exp Pediatr. 1998;41(3):415-419.   Published online March 15, 1998
Diffuse mesangial sclerosis(DMS) is one of the underlying pathology of congenital and infantile nephrotic syndrome. Infants with DMS develop nephrotic syndrome before 2 years of age and progress to end stage renal disease within 3 years of age. The authors experienced a case of isolated DMS in a 4-month-old male infant who had nephrotic syndrome for 1 month. The diagnosis...
Original Article
Total Anomalous Pulmonary Venous Connection : The Results of 23 Consecutive Patients
Young-Hwue Kim, Jae-Kon Ko, In-Sook Park, Tae-Jin Yun, Dong-Man Seo, Chang-Yee Hong
Clin Exp Pediatr. 1998;41(3):346-353.   Published online March 15, 1998
Purpose : Surgical risk of total anomalous pulmonary venous connection(TAPVC) is high, especially in patients with early presentation resulting from pulmonary venous obstruction or with advanced pulmonary vascular obstructive disease(PVOD). We reviewed our experience of primary correction of TAPVC and examined the surgical outcome and risk factors. Methods : From June 1991 to Sept. 1996, 23 neonates or infants who were...
Clinical Studies of Aseptic Meningitis in Pusan Area in 1996
Ji Yeon Hur, Tag Soo Kim, Woo Je Cho, Sung Won Kim
Clin Exp Pediatr. 1998;41(1):38-46.   Published online January 15, 1998
Purpose : We report clinical features and viral studies on 153 children with aseptic meningitis in the Pusan area in 1996 and compare the results of this study with those of other reports in 1990 and 1993. Methods : One hundred fiffy-three children with aseptic meningitis who have been admitted to the Department of Pediatrics, St. Benedict Hospital between July and October 1996 were...
The Clinical Aspects of Septic Arthritis in Children
Milim Koo, Dongsoo Kim
Clin Exp Pediatr. 1997;40(12):1731-1744.   Published online December 15, 1997
Purpose : Acute septic arthritis in infancy and childhood is uncommon. Delay of diagnosis and inappropriate treatment of septic arthritis results in permanent physical sequelae. We studied the initial treatment, clinical manifestations, involved sites, and etiologic organisms of septic arthritis. Methods : We reviewed 74 patients who were diagnosed septic arthritis in Departments of Pediatrics and Orthopedic Surgery, Yonsei University College of Medicine from July 1986...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
A Study of Serum Cytokines in Nephrotic Syndrome
Mea Young Chang, Jae Ho Lee
Clin Exp Pediatr. 1997;40(12):1701-1706.   Published online December 15, 1997
Purpose : It has been reported that patients with nephrotic syndrome have high serum IgE value and IL-4 involve in IgE synthesis, IL-6 is an autocrine growth factor for the proliferation of mesangial cells. We studied association between serum cytokines and of nephrotic syndrome. Methods : We measured serum IL-6, IL-4, IFN-Υ, CD23 in 14 children with nephrotic syndrome and 3 healthy children by...
Diagnostic and Therapeutic Efficacy of Endoscopic Retrograde Cholangiopancreatography in Children
Kyung Mo Kim, Ho Soon Choi, Sung Koo Lee, Myung Hwan Kim, Chong Hyun Yoon, Dong Myung Lee
Clin Exp Pediatr. 1997;40(12):1681-1691.   Published online December 15, 1997
Purpose : Endoscopic retrograde cholangiopancreatography(ERCP) may provide more definite diagnosis, preoperative guidance, and endoscopic therapy in many children with known or suspected disorders of the pancreas and biliary tract. But the reports about the ERCP in children are rare, so this study is conducted to evaluate the indication, efficacy and safety of the ERCP in children. Methods : Twenty nine ERCPs in 19 children...
The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 1997;40(12):1645-1650.   Published online December 15, 1997
Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting, convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and survivors have significant risk of developmental disability and chronic somatic illness. However,...
Role of Serum Ca and 1,25(OH)2D3 as Predictor in Bone Metabolism Abnormality by Chronic Medication of Anticonvulsant
Ho-Soo Kim, Hyun-Ho Kang, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1997;40(11):1567-1571.   Published online November 15, 1997
목 적 : 항경련제의 장기복용에 의하여 저칼슘혈증, 구루병, 골연화증 등의 골대사 이상은 성 장기 소아의 중대한 문제점이 될 수 있으므로 조기발견 및 치료가 중요하다. 이에 본 저자들은 골대사 이상의 예측을 위한 지표로서 혈청 Calcium(이하 Ca), 1,25(OH)2D3에 대하여 연구를 시행하였다. 방 법 : 경희의대 소아과에서 경련성 질환으로 진단 받고 6개월 이상 항경련제를 복용한 48 명을 대상으로 하였다. 이들중 항경련제 단독복용은 37명, 두 가지 이상의 혼합복용군은 11명 이었으며,...
Analysis of Urinary Mass Screening for Elemantary, Junior and High School Children Over a 8-year Period in Seoul
Chong Guk Lee, Dong Whan Lee, Sae Won Yang, Sung Ho Cha, Chang Ho Hong, Yong Mook Choi, Hyun Soon Lee, Sung Jae Seo
Clin Exp Pediatr. 1997;40(10):1347-1359.   Published online October 15, 1997
Purpose : The urinary mass screening program for the detection of proteinuria had been performed for a school age population in the city of Seoul since 1981. However, systematic evaluation for this program had never been done. We, therefore, designed a systematic evaluation in corporation with the Seoul School Health Center for students with proteinuria identified in the mass screening to determine the prevalence...
Case Report
A Case of Double Duodenal Web Associated with Peptic Ulcer
Sun Young Park, Jin Hwa Jung, Jeong Ho Lee, Jong Dae Jo
Clin Exp Pediatr. 1997;40(9):1319-1324.   Published online September 15, 1997
Duodenal web is a very rare congenital anomaly which usually causes clinical features of intestinal obstruction from early infancy. It shows characteristic findings in the radiologic contrast study or endoscopy. But in the cases with large openings, preoperative diagnosis of web is difficult and often is overlooked until adolescence or adulthood because of delayed onset of symptoms. Duodenal web is usually single near the...
Original Article
Prediction of Steroid Responsiveness in the Primary Nephrotic Syndrome Using Urinary β2-Microglobulin Level and N-Acetyl-β-D-Glucosaminidase Activity
Kwang In Lee, In Seok Lim, Eung Sang Choi
Clin Exp Pediatr. 1997;40(9):1285-1292.   Published online September 15, 1997
Purpose : Considering that renal biopsy is not routinely indicated in nephrotic syndrome in children and the risk of the procedure, we studied that it is possible to predict steroid responsiveness in nephrotic syndrome and the difference in responsivenss is related with the histopathologic type using urinary β2-microglobulin and N-Acetyl-β-D-Glucosaminidase activity as a safe and noninvasive method. Methods : We measured serum creatinine, albumin, cholesterol...
An Epidemic of Aseptic Meningitis in Summer 1996 and Global Analysis and Comparision of It with 1993
Jung Ah Chung, Young Jun Kim, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(8):1081-1090.   Published online August 15, 1997
Purpose : In the Summer 1996, there was an outbreak of aseptic meningitis without sequele. 116 cases who were admitted to our Department during a six month period from May to October, 1996. Therefore, we report epidemic of aseptic meningitis in 1996 and analyze and compare it with a epidemic of aseptic meningitis in 1993. Methods : We studies about clinical manefestation and laboratory finding...
Case Report
A Case of Choledochal Cyst with Anomalous Pancreaticobiliary Ductal Union
Je Woo Kim, Hyun Chul Bae, Ki Sup Chung, Seok Joo Han, Eui Ho Hwang
Clin Exp Pediatr. 1997;40(7):1010-1014.   Published online July 15, 1997
Choledochal cysts are congenital or acquired lesions of the biliary tree with a cystic dilatation of the bile duct. We experienced a choledochal cyst accompanying acute pancreatitis caused by anomalous pancreaticobiliary ductal union(APBDU) in a 2 year old boy. The choledochal cyst associated with APBDU is rarely encountered in the clinical field, and thus we report this case with the presentation of abdominal ultrasonogram, computed...
Original Article
Diagnostic Value of Reticulated Platelet in Thrombocytopenia
Song Hee Park, Hwang Min Kim, Baek Keun Lim, Young Hak Shim, Chang Hoon Lee, Myung Seo Kang
Clin Exp Pediatr. 1997;40(6):850-856.   Published online June 15, 1997
Purpose : We performed this study to determine the diagnostic significance and useful cut-off value of reticulated platelet, which can be used for discriminating the destructive thrombocytopenia from underproductive thrombocytopenia. Methods : We evaluated 37 patients with thrombocytopenia who were admitted to the Wonju christian hospital from March to July, 1995. All patients were evaluated with bone marrow megakaryocyte count. We divided them into two...
The Retrospective Study on Antibiotics Treatment in Acute Gastroenteritis
Ji Hye Kim, Sung Hee Oh
Clin Exp Pediatr. 1997;40(6):826-834.   Published online June 15, 1997
Purpose : Most of the gastroenteritis due to viruses and some bacteria can be successfully managed by oral and/or intravenous fluid-electrolyte replacement and antibiotic therapy is unnecessary and even harmful. It is, however, not uncommon practice to prescribe antibiotics when acute gastroentritis is suspected. Therefore authors analysed the clinical courses of the patients treated for acute non-bacterial gastroenteritis in a university hospital to assess...
The Perinatal Complications in Infants of Mothers with Gestational Diabetes Mellitus
Ju Yeon Yeo, Seong Won Yang, Hye Kyung Han, Mi Ryung Um, Woo Gill Lee, Mi Na Lee, Hak Chul Jang, Ho Yeon Jung, Eun Sung Kim, Kyu Byung Jung
Clin Exp Pediatr. 1997;40(6):809-917.   Published online June 15, 1997
Purpose : This study was performed to examine the impact of gestational diabetes mellitus (GDM) on perinatal outcomes, especially macrosomia and metabolic complications in Korean women. Methods : We studied perinatal outcomes of 65 women with GDM who delivered a singleton infant and were not complicated by medical disease that might effect the fetal growth, 65 women with normal glucose tolerance were selected to match subject...
Clinical Features of Adrenocortical Neoplasms
Jung-Eun Lee, So-Chung Chung, Duk-Hi Kim, Ho-Sung Kim
Clin Exp Pediatr. 1997;40(5):680-689.   Published online May 15, 1997
Purpose : Adrenocortical tumors are uncommon in children and comprise only a small proportion of primary adrenal neoplasms. The biologic behavior of these tumors may be very difficult to predict, and their rarity has hindered identification of clinical characteristics. Patients with functioning tumors have excessive steroid hormone production, and the clinical manifestation depends on the predominant hormone produced. The detection of...
The Efficacy of Routine Liver Function Test Follow Up in Epileptic Children
Dae Hun Pee, Hyung Joo Sohn, Young Kyoo Shin, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1997;40(5):660-671.   Published online May 15, 1997
Purpose : Routine liver function test follow up is done in epileptic children receiving antiepileptic drugs to prevent hepatotoxicity induced by these drugs. But rarely seen are the abnormalities of liver function test, and seldomly are these abnormalities accompanied by the clinical manifestation. This study is carried out to assess the efficacy of routine liver function test follow up in...
A Study of Vascular Reactivity Change in Nephrotic Syndrome Children Using Plethysmography
Jae Won Shim, Byoung Hoon Yoo, In Suk Lim
Clin Exp Pediatr. 1997;40(5):650-659.   Published online May 15, 1997
Purpose : The nephrotic syndrome is characterized by proteinuria, hypoproteinemia, edema and hyperlipidemia. These can change body homeostasis and cause hypertension. This study was designed to determine the relationship between the forearm vasodilating capacity and serum cholesterol level of nephrotic syndrome patients. Methods : 15 Nephrotic syndrome patients and 17 normal control children who visited Chung-ang University Youngsan Hospital from Sep....
Echocardiographic Study of the Ventricular Septal Defect with Subaortic Ridge
Kyeung Hee Moon, Pyoung Han Hwang, Chan Uhng Joo
Clin Exp Pediatr. 1997;40(5):629-634.   Published online May 15, 1997
Purpose : The easy recognition and characterization of a discrete or fixed subaortic ridge by echocardiography provides a method for prospective study of the coexistence of ventricular septal defect(VSD) and subaortic ridge. In the presence of a VSD, a subaortic ridge may be clinically silent, but the obstruction can progress if the VSD is surgically or spontaneously closed. This study...
Case Report
A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
Nan Yee Kye, Kon Hee Lee, Jae Kook Cha, Hye Sun Yoon, Won Keun Song
Clin Exp Pediatr. 1997;40(4):578-583.   Published online April 15, 1997
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC...
A Case of Lymphocytic Interstitial Pneumonia
Ho Young Lee, Hwang Min Kim, Mee Kyung Namgoong, Jong Soo Kim, Soon Hee Jung, Dong Jin Kim
Clin Exp Pediatr. 1997;40(4):572-577.   Published online April 15, 1997
Lymphoid interstitial pneumonia(LIP) is an uncommon process in childhood, and is characterized by interstitial accumulation of mature lymphocytes, plasma cells and reticuloendothelial cells. LIP is believed to have autoimmune or immunologic pathogenesis, because it is frequently associated with acquired immune deficiency syndrome, Epstein-Barr virus infection, common variable immunodeficiency. The patient described in this report had idiopathic thrombocytopenic purpura, Evans syndrome...
Original Article
Fixed Subaortic Stenosis in Children
Eun Jin Choi, Byung Ho Choi, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1997;40(4):505-511.   Published online April 15, 1997
Purpose : This study attempted to describe the Doppler and two-dimensional echocardiographic features of fixed subaortic stenosis, the de novo occurrence and progression of this lesion and to review its etiology, treatment and course. Methods : We studied 17 patients of fixed subaortic stenosis who, between Jan. 1993 and Jan. 1996, ware diagnosed by echocardiographic examination at Kyungpook National University Hospital....
Relationship between Antistreptolysin O Titer and Number of Colonies from Throat Swab Culture Plate in Group A Beta-hemolytic Streptococcal Carriers and Normal School Children
Sungho Cha
Clin Exp Pediatr. 1997;40(4):480-488.   Published online April 15, 1997
Purpose : To know the true carrier rate and the immunologic responses(antistreptolysin O :ASO) to beta-hemolytic streptococci which obtained from normal school children with or without carrying streptococci. And to study the clinical meaning of the number of organisms found in culture. Methods : One hundred ninty-eight first grade of elementary school children were included. I obtained throat swab culture from...
Case Report
A Case of Multicystic Encephalomalacia in a Liveborn Twin with a Stillborn Co-twin
Mi Ya Park, Kyung Hee Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1997;40(3):429-433.   Published online March 15, 1997
Multicystic encephalomalacia is the condition defined anatomically by the presence of multiple cavities in the great part of both cerebral hemispheres. The most common cause of the condition was regarded as the circulatory disturbance during the perinatal period. Also,neonatal asphyxia was the most important cause of the circulatory disturbance. But we experienced a case of multicystic encephalomalacia in a liveborn twin with a stillborn...
A Case of Granular Acute Lymphoblastic Leukemia with t(5p;5p) Arising in Down Syndrome Infant
Soon Ja Lee, Young Ho An, Hai Lee Chung
Clin Exp Pediatr. 1997;40(3):417-422.   Published online March 15, 1997
Granular lymphoblast which is characterized by the presence of clearly defined azurophilic cytoplasmic granules are a relatively uncommon finding and indicate a negative impact on prognosis of childhood ALL. Granular ALL is more common in FAB L2 cases but there is no significant difference by immunophenotype and no specific cytogenetic abnormality correlated with clinical significance of granular ALL has been reported. We present a case...
Original Article
Prophylactic Treatment of Anemia of Prematurity with Recombinant Human Erythropoietin and High Doses of Iron
Young Ho Lee, Ahn Hong Choi, Soon Yong Lee, Jeong Sook Park, Bong Keun Choi, Hyoung Shim Chang
Clin Exp Pediatr. 1997;40(3):361-367.   Published online March 15, 1997
Purpose : We conducted randomized study to determine whether high doses(6mg/kg/ day) of iron would exert a more supplemental effect than low doses(3mg/kg/day), and which regimen of recombinant human erythropoietin(rHuEPO) and iron would be more beneficial in the prophylactic treatment of anemia of prematurity. Methods : We randomly assigned 38 sick premature infants who were more likely than symptom-free premature infants requiring erythrocyte transfusions for...
The Hematologic Effect of Antiepileptic Drug
Dae Hun Pee, Young Kwan Park, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1997;40(2):217-224.   Published online February 15, 1997
Purpose : There have been controversies on the hematologic effects of antiepileptic drugs according to the mono or combined antiepileptic therapy. We evaluated the hematologic changes of the patients who have been taking antiepileptic drugs for more than 4 months and compared the changes of these values according to the mono or combined therapy. Methods : From May,1989 to April,1995, we had examined the blood...
Clinicopathological Study about Childhood Primary Nephrotic Syndrome Resistant to 4-week Daily Steroid Therapy
Jung Sue Kim, Il Soo Ha, Hae Il Cheong, Yong Choi
Clin Exp Pediatr. 1996;39(12):1729-1735.   Published online December 15, 1996
Purpose : Steroid-resistant nephrotic syndrome in children is difficult to manage and tends to progress to chronic renal failure. We studied clinicopathological correlations in primary nephrotic syndrome in children resistant to 4-week daily steroid therapy. Methods : Among children who had been admitted to Seoul National University Children's Hospital during the period between Oct. 1985 and Jul. 1995 and diagnosed as primary nephrotic syndrome, 87...