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Original Article
Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
Clin Exp Pediatr. 1999;42(10):1392-1402.   Published online October 15, 1999
Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations...
Effects of Hepatitis B Revaccination in Nonresponsive Children
Ui Chong Chong, Mi Ran Kim, Chong Young Park
Clin Exp Pediatr. 1999;42(6):778-782.   Published online June 15, 1999
Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule. Methods :...
A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
Clin Exp Pediatr. 1999;42(2):180-185.   Published online February 15, 1999
Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV...
Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
Clin Exp Pediatr. 1998;41(11):1498-1508.   Published online November 15, 1998
Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2...
Clinical and Pathological Comparison of Neonatal Hepatitis and Extrahepatic Biliary Atresia in Korean Children
Jae Hong Park, Ju Suk Lee, Su Eun Park, Chang Hun Lee
Clin Exp Pediatr. 1998;41(10):1372-1379.   Published online October 15, 1998
Purpose : Neonatal hepatitis and congenital extrahepatic biliary atresia are two major causes of neonatal cholestasis. But the method of therapeutic trials used for each disease is essentially different. Nonetheless, it is very difficult to differentiate these diseases clinically and histologically. This study is aimed to find out major differences between the two by clinical characteristics and scoring of various...
Erratum
A Case of Type I Autoimmune Hepatitis in Children
Soeng Hun Kim, Su Eun Park, Jeong Hwa Choi, Jae Hong Park, Su Yung Kim
Clin Exp Pediatr. 1998;41(7):979-983.   Published online July 15, 1998
Autoimmune hepatitis is an inflammatory liver disease characterized histologically by a dense mononuclaear cell infiltration of the portal tract, serologically by the presence of non-organ and liver specific autoantibodies and increased concentrations of IgG in the absence of a known etiology. Two types of autoimmune hepatitis are classified in the peripheral blood of antinuclear antibody and/or in antismooth muscle antibody(ANA/ASMA)...
Original Article
Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(4):451-455.   Published online April 15, 1998
Purpose : The universal vaccination against hepatitis B during early infancy is the only effective way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio at 2, 4, 6 months of age in babies of HBs antigen negative mothers. Methods : One...
Seroepidemiology of Hepatitis A in Taejon, Korea 1996
Kyung-Yil Lee, Ki-Hun Song, Jin-Han Kang
Clin Exp Pediatr. 1998;41(1):53-61.   Published online January 15, 1998
Purpose : We experienced an outbreak of hepatitis A in Taejon, Korea for the summer of 1996. Recently a shift in hepatitis A incidence from children to adults has been well noted in Korea. For the purpose of possible measures in preventing hepatitis A, we studied a seroepidemiology of hepatitis A in Taejon. Methods : We measured IgG anti-HAV antibody(HAVAB MEIA, Abbott) from 722...
The Change of Anti-HBs Titer after Injection of HBIG and HBV in Newborn Delivered from HBsAg Carrier Mothers
Qoae Suk Roh, Jin Young Jung
Clin Exp Pediatr. 1997;40(8):1141-1148.   Published online August 15, 1997
Purpose : We studied prevention effects of vertical transmission of Hepatitis B with follow-up, through the change of Anti-HBs titers during 9 months after injection of Hepatitis B immunoglobulin(HBIG) and Hepatitis B vaccine(HBV) at birth in newborn delivered from Hepatitis antigen carrier mothers. Methods : This study was performed on newborn delivered from HBsAg carrier mothers at Hae Sung Hospital from Feb. 1995 to May...
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
Clin Exp Pediatr. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
Measles Hepatitis in Children
Sang Gil An, Ji Eun Wuon, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1996;39(10):1371-1377.   Published online October 15, 1996
Purpose : Measlesinfection in children hasbeen known to havemany complications including hepatitis. But there has been no appropriate study about measles hepatitis in children. So we studied to facilitate the understanding of measles hepatitis in children by analyzing their clinical features and laboratory findings. Methods : We investigated 164 patients who were admitted to the Department of Pediatrics, Seoul Red Cross Hospital due to measles...
The Study of Serum Aminotransferase and AST/ALT Ratio in Pediatric Patients with Acute Hepatitis
Soo Mi Jung, Chang Rang Kang, Man Taeg Oh, Jong Duck Kim
Clin Exp Pediatr. 1996;39(10):1364-1370.   Published online October 15, 1996
Purpose : Serum level of the aminotransferase is the most common test in use to assess hepatocellular injury and are sensitive test of hepatocyte necrosis, but both AST and ALT level in serum rise in a variety of hepatic disorders. Some clinical study reports that AST/ALT ratio was possible to predict prognostic outcome of infants with liver disease. We have tried to assess whether...
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
Clin Exp Pediatr. 1996;39(9):1254-1259.   Published online September 15, 1996
Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been...
Case Report
A Case Report of Autoimmune Hepatitis Associated with Choledochal Cyst and Pancreatitis
Kyung Ran Park, Sun Young Lee, Soon Young Kim, Hyoung Shim Chang, Nam Su Back, Chong Jai Kim, Joong Gon Kim, Jeong Kee Seo
Clin Exp Pediatr. 1996;39(8):1146-1150.   Published online August 15, 1996
Autoimmune hepatitis in children is a rare and severe inflammatory disease of unknown etiology, and progress to cirrohosis and liver failure, generally is responsive to immunosuppressive therapy. It is more prevalent in women than men, and characterized by the presence of circulating autoantibodies, a high serum globulin. Extrahepatic manifestations such as thyroiditis, ulcerative colitis, glomerulonephritis and autoimmune hemolytic anemia, are associated. We report, to our...
Original Article
Ischemic Hepatitis in Children after Cardiac Operation -Analysis of Clinical Characteristics, Risk Factors and Outcome-
Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 1995;38(11):1540-1546.   Published online November 15, 1995
Purpose : We have experienced frequently the ischemic hepatitis after cardiac operations which shows rapid striking rise of transaminase. But the ischemic hepatitis in children after cardiac operation is not defined yet in Korea. We examined the clinical characteristics and analyzed the risk factors and outcome in 20 children who showed typical clinical course of ischemic hepatitis after cardiac operation. Methods...
Clinical and Histologic Changes in Children with Chronic Hepatitis B Virus Infection after Alpha Interferon Therapy
Kyung Mo Kim, Soo Jong Hong, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Joo Ryoung Huh
Clin Exp Pediatr. 1995;38(9):1232-1241.   Published online September 15, 1995
Purpose : Several trials in children for chronic hepatitis B have shown the efficacy of alpha interferon in eliminating hepatitis B virus replication, accompanied by an improvement in the liver cell damage. But reports about the alpha interferon therapy are rare in Korean children and there is no report about histologic changes even with adult. So we tried to...
Erratum
Vertical Transmission of Hepatitis C Virus in Infant of the Mother Who Had Active Hepatitis C during Pregnancy
Mi-Jeong Lee, Mi-Jeong Lee
Clin Exp Pediatr. 1995;38(6):857-862.   Published online June 15, 1995
Vertical transmission of hepatitis C virus(HCV) has been reported recently. The authors experienced one case of vertical transmission of HCV in infant of the mother who had active hepatitis C durig pregnancy. At delivery, HCV RNA(+), IgG anti HCV Ab(+), IgM anti HCV Ab(+), mile elevation of liver aminotransferase level and mile fatty liver of ultrasonography were found in the...
Original Article
Clinical and Histologic Study of Progressive Muscular Dystrophy Which was Considered as Chronic Hepatitis
Jae Kwang Kim, Ki Sup Chung, Tae Seung Kim
Clin Exp Pediatr. 1995;38(2):216-222.   Published online February 15, 1995
Purpose : The authors have experienced thirty three children of progressive muscular dystrophy. 10 children of these(30.3%) were considered as chronic hepatitis because of persistent, u nexplained elevated serum aminotransferase values. We performed this study in order to evaluate the characteristics of age distribution, clinical and histologic features in children considered as chronic hepatitis. Methods : This study was performed on...
Case Report
A Case of Remission of Systemic Juvenile Rheumatoid Arthritis (Still's Disease) Treated with High-dose Intravenous Gammaglobulin
Yon Sook Rho, Yun Woo Lee, Sang woo Kim
Clin Exp Pediatr. 1994;37(12):1767-1772.   Published online December 15, 1994
High dose intravenous gammaglobuline (IVIG) therapy is effective in some of the autoimmune diseases. Although the exact mechamism of action of IVIG is uncertain, the action as a neutralizing antibody against unknown etiologic agents, the action of blocking of Fc receptors of effector cells, or the action as a antiidiotypic antibody are suggested. We report a case of 12 year old...
Original Article
Epstein-Barr Viral Hepatitis in Childhood
Soo Kyung Lee, Ki Sup Chung
Clin Exp Pediatr. 1994;37(8):1124-1135.   Published online August 15, 1994
We analysed 58 patients who were admitted to the Department of Pediatrics, yonsei University College of Medicine due to infectious mononucleosis from January 1986 to August 1992. Of 58 patients who had responses to IgM to EBV viral capsid antigen and/or heterophil antibody, 35 patients had hapatitis. Of 35 hepatitis patients, group I consisted of 22 patients who had only...
Case Report
A Case of Steven-Johnson Syndrome Associated with Cholestatic Hepatitis
Tae-Hee Park, Ran-Ju Kim, Byoung-Geun Lee, Soo-Chul Cho, Dae-Yeol Lee
Clin Exp Pediatr. 1994;37(7):1016-1019.   Published online July 15, 1994
A12-year-old boy developed cholestatic hepatitis with Steven-Johnson syndrome following the use of amoxicillin. The skin lesion and general condition were improved over 2 weeks, but jaundice was gradually aggrevated. We performed liver biopsy, on 30th hospital day, which showed cholestatic hepatitis. The patient improved gradually and liver function was normalized 5 months later.
Original Article
A Clinical Study on Chronic Hepatitis b in the Children
Bon Su Koo, Han Sang Joo, Yung Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1994;37(6):767-775.   Published online June 15, 1994
The author observed clinical study and response of -interferon treatment of 43 cases of chronic hepatitis who were admitted to Department of Pediatrics Pusan National University College of Medicine during the period of 4 year 6 months from Jenuary, 1988 to Jun, 1992. The results were as follows: 1) Of 43 patients with chronic hepatitis CPH was 17 cases (39.5%) and CAH...
Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique
Jin Sook Kim, Young Ran Yoon, Mi Kyung Kim, Hye Kyung Han, Mi Ryung Um, Kyung Hoon Choi, Mi Na Lee, In Keol Moon, In Kweon Han
Clin Exp Pediatr. 1994;37(2):231-239.   Published online February 15, 1994
Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase...
The Effect of Prolonged Treatment in Children with Chronic Hepatitis B with Combination of Alpha-Interferon and Acyclovir
Jeong Ok Hah, Kyoung A Lee
Clin Exp Pediatr. 1993;36(12):1701-1706.   Published online December 15, 1993
This study was conducted to evaluate the effect of prolonged treatment in children with chronic hepatitis B will combination of alpha-interferon and acyclovir. The study population consisited of & patients with chronic hepatitis B who showed histological findings compatible with chronic active hepatitis (4 cases) or chronic persistent hepatitis (3 cases) on liver biopsy and had elevated AST and ALT with...
The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time
Joon Young Lee, Yong Sik MIn, Chang hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(5):656-663.   Published online May 15, 1993
We studied anti-HBs titer, positive and effective rate in relation to dosages(5, 10) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5 of Hepavax was administered intramusculary at 1 month, 2 months and 6 months age, in other group (n=11), 10 of Hepavax at...
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Case Report
Three Cases of Post-transfusion Hepatitis C
Kyung Un No, Ho Seong Kim, Ji Won Choi, Dong Wook Kim, Cheol Ho Jang, Beom Su Park, Jeong Kee Seo, Gyeong Hoon Kang, Je Geun Chi
Clin Exp Pediatr. 1992;35(9):1255-1262.   Published online September 15, 1992
Hepatitis C virus has been known to be the main cause of post-transfusion non-A, non-B hepatitis. The authors experienced three cases of hepatitis C. All were associated with blood transfusions. They had no specific symptoms, and the levels of aminotransferases were markedly elevated and showed severe fluctuations in two cases. Anti-HCV tested two or three times were all positive, and...
Original Article
Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
Clin Exp Pediatr. 1992;35(7):890-901.   Published online July 15, 1992
The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed. Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months....
Hepatic Rickets in Infancy with Neonatal Hepatitis
Mi Koo Kang, Eun Young Cho, Soo Jong Hong, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1992;35(4):527-533.   Published online April 15, 1992
We had treated a hepatic rickets in 6 infants with neonatal hepatitis from June 1989 to August 1990 at Asan Medical Center. The results were as follows 1) Age of 6 patients were below 4 months and 4 patients were male, 2 patients were female. 2) The clinical findings were hepatosplenomegaly(5 cases), jaundice(4 cases), craniotabes (4 cases), failure to thrive(2 cases), hypocalcemiac seizure(2...
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...