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Original Article
Clinical Considerations of the Mediastinal Tumors in Children
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(1):98-107.   Published online January 15, 1992
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a...
Incidence Estimation of Leukemia among Korean Children
Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Yoon-Ok Ahn
Clin Exp Pediatr. 1992;35(1):80-87.   Published online January 15, 1992
Leukemia is a neoplasm arising from the malignant transformation of hematopoietic cells. The incidence data of leukemia have not been available for Korean as a whole. The present study was therefore undertaken in order to estimate the incidence of childhood leukemia among Korean. The study population of this investigation was the beneficiaries of the Korea Medical Insurance Corporation(KMIC) during the period...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
Morphological study on the development of human fetal kidney.
Hee Young Shin, Kwang Wook Ko, Je Geun Chi
Clin Exp Pediatr. 1991;34(8):1045-1056.   Published online August 31, 1991
A total of 293 human fetal kidneys, including those of 42 embryos are studied for the elucidation of temporal development of the kidney. These specimens were interpreted as normal by thorough postmortem examinations. The age of the specimens was determined by developmental horizon criteria in embryos and by correlating crown-rump length in fetuses. Embryos were embedded in toto, cut in various planes and reconstructed...
A case of pancytopenia associated with mycoplasmal pneumonia.
Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
Clin Exp Pediatr. 1991;34(6):826-831.   Published online June 30, 1991
Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes- tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm- bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate, positive direct Coombs test, reticulocytosis and DIC are known hematologic features. This 12 years old female patient was presented with pneumonia and pancytopenia....
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Two cases of nasopharyngeal carcinoma in children.
Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):587-593.   Published online April 30, 1991
Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de- scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent- ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of childhood, and has not been reported in Korean child. We experienced two cases of nasopharyngeal carcinoma in a 10...
Malignant Schwannomas in children.
Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):525-531.   Published online April 30, 1991
Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed. Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases, three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 : 2. In...
Clinical study of Kasabach-Merritt syndrome.
Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(3):371-379.   Published online March 31, 1991
A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June, 1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1: 1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem- ities 5, trunk...
Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(1):74-82.   Published online January 31, 1991
Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11 patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,...
A case of Second Malignant Neoplasm Complicating Hodgkin's Disease in Remission.
Hong Hoe Koo, Jong Woon Choi, Sang Oh Na, Il Soo Ha, Hee Young Shin, Hyo Seop Ahn, Yeon Lim Suh, Chul Woo Kim, Je Geun Chi
Clin Exp Pediatr. 1990;33(4):564-572.   Published online April 30, 1990
Recent advances in the treatment of cancer have resulted in increased survival and possible cure for many malignant disorders, particularly childhood cancers. There has been a marked improvement in the treatment of childhood Hodgkin’s disease, and five-year survival rates for even advanced stages of Hodgkin’s disease approach or exceed more than 75% with modern treatment policies. However, successful therapy in childhood cancer is frequently...
A case of congenital dyserythropoietic Anemia.
Sang Oh Na, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Il Soo Ha, Hyo Seop Ahn, Doek Ja Oh, Myoung Hee Park
Clin Exp Pediatr. 1990;33(3):410-415.   Published online March 31, 1990
The congenital dyserythropoietic anemia refers to a group of hereditary disorders of erythropoiesis characterized by ineffective erythropoiesis, multinuclearity of erythroblasts, and secondary hemo- chromatosis. The authors report a case of anemia in a 4 month-old girl whose bone marrow showed dyserythropoietic features. A brief review of referential literatures was made.
Burkitt Lymphoma in Children.
Soo Jong Hong, Dong Kyu Jin, Hee Young Shin, Hyo Seop Ahn, Chang Yee Hong, Je G Chi
Clin Exp Pediatr. 1988;31(4):482-491.   Published online April 30, 1988
Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with...
Captopril in Children with Renovacular Hypertension.
Yong Choi, Hoan Jong Lee, Hee Young Shin, Kwang Wook Ko, Chang Yee Hong
Clin Exp Pediatr. 1985;28(1):58-67.   Published online January 31, 1985
Captopril, a kind of converting enzyme inhibitors, is a promising anti-hypertensive drug, which is developed recently, and studied mainly in adult patients. We administered captopril to 4 children with renovascular hypertension, three of them accompanied Takayasu's arteritis and the remainder had isolated lesion. Three to five times of initial trials were performed on each patient with 12.5 mg of captopril....
Renal Disease in Children-A Ten-Years Experience.
Hee Young Shin, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1983;26(7):681-686.   Published online July 31, 1983
Statistical analysis of inpatients of Seoul National University Hospital from 1972 to 1981 who had renal diseases was performed with respect to their disease pattern, annual incidence of each disease, and age distribution. From 1972 to 1981 renal disease was found in 831 patients among 11,226 total inpatients (7.4%). Male to female ratio of renal disease patients was 2.2 to 1, while male to...
CNS Lesions in Tuberculous Meningitis.
Hee Young Shin, Jung Hwan Choi, Jeong Kee Seo, Kyung Mo Yeon, Kwang Wook Ko, Hahn Woong Choe
Clin Exp Pediatr. 1983;26(3):213-219.   Published online March 31, 1983
Clinical features of 20 patients who were diagnosed as tuberculous meningitis at Seoul National University Hospital from Jan. ’82 to Dec. ’82 were analyzed with special respect to their computed tomographic findings of the brain. Age at the onset of the disease ranged from 7 month. to 12 9/12 year with the mean age of 3 11/12 year. Fifteen cases were under...