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Original Article
Clinical Study of Effectiveness Topiramate in Children with Intractable Epilepsy
Young Mi Choi, Sa Jun Chung
Clin Exp Pediatr. 2001;44(1):62-67.   Published online January 15, 2001
Purpose : Topiramate(TPM) is a new anticonvulsant with multiple action mechanisms which should theoretically represent a wide therapeutic spectrum. However, there is still little clinical experience of its use in Asian children with epilepsy. Methods : The patients were total 96 children who were treated with more than 2 anticonvulsants but poorly controlled seizure activity. TPM was given as add-on therapy...
The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole
Jun Ho Kim, Doo Kwun Kim
Clin Exp Pediatr. 2000;43(10):1356-1363.   Published online October 15, 2000
Purpose : Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant. Methods : Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure....
A Clinical Study of Acute Symptomatic Seizures in Children
Kyeong Eun Lee, Won Seop Kim
Clin Exp Pediatr. 2000;43(9):1254-1262.   Published online September 15, 2000
Purpose : To determine the incidence, etiology, sex, age, seizure type and prognosis of acute symptomatic seizures in children and evaluate the hypothesis that acute symptomatic status epilepticus( SE) is associated with an increased risk of subsequent unprovoked seizure compared with the risk of acute symptomatic seizure without SE. Methods : Five hundred and sixty-eight convulsive children visited the Pediatric Department of Chungbuk National University...
Case Report
A Case of Primary Hypomagnesemia
Kyoung A Chun, Sung Pil Jang, Young Dae Ham, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2000;43(8):1153-1156.   Published online August 15, 2000
Primary hypomagnesemia is a rare inherited disorder and it is considered to be due to either a defect in the intestinal transport of magnesium or a defect in renal tubular transport. It is important to measure the urinary excretion of magnesium to differentiate the causes of magnesium deficiency. We report here an one-month-old female infant of primary hypomagnesemia who presented...
Original Article
Factors Related to the Outcome of Neonatal Seizures
Sung Koo Kim, Ran Lee, In Kyu Lee, Ki Joong Kim, Young Seung Hwang
Clin Exp Pediatr. 2000;43(2):267-273.   Published online February 15, 2000
Purpose : Seizures during the neonatal period may be an important indicator of serious neurologic abnormalities and can cause permanent neurologic sequelae. We attempted to find and analyze the factors related to the outcome of neonatal seizures. Methods : Seventy-six newborns with seizure were reviewed. The outcomes were analyzed according to etiologic diseases, gestational ages, characteristics of seizure, and neuroimaging and...
Usefulness of Brain Tc-99m HMPAO SPECT in Establishing Lateralization of Intractable Seizure in Children
Suck-Hee Ahn, Young-Ho Rah, Sa-Jun Chung, Eu-Hyun Cho
Clin Exp Pediatr. 1999;42(12):1711-1716.   Published online December 15, 1999
Purpose : To determine the role of Tc-99m HMPAO SPECT imaging in children with intractable seizure by evaluating the interictal period. Methods : We compared the EEG, CT and MRI medical records with those of Tc-99m HMPAO SPECT in 42 patients with intractable seizure referred to Kyunghee University Hospital, from April 1983 to September 1998, retrospectively. Results : Mean age was 8.3 years...
Clinical Study of Post-Traumatic Seizure in Childhood and Adolescence
Jang Weon Moon, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 1999;42(2):227-232.   Published online February 15, 1999
Purpose : As morbidity and mortality resulting from physical trauma have significantly increased, the importance of trauma concerning medical, legal, and socioeconomic issues has been widely documented. Studies of post-traumatic seizure after head trauma have been reported, but mostly in adults. So this study was performed to analyse clinical findings on head trauma patients under 20 years of age. Methods :...
Case Report
A Case of DiGeorge Syndrome
Young Joo Son, Yu Sik Jeon, Soon Lee Jung, Kyuchul Choeh
Clin Exp Pediatr. 1998;41(3):390-395.   Published online March 15, 1998
We experienced a case of DiGeorge syndrome in a 25-day-old male infant presented with micrognathia, short neck, fish-shaped mouth and intractable seizures with a loading dose of phenobarbital & dilantin. The serum calcium level was 3.7mg/dl, ionized calcium level was 0.62mmol/L, and parathyroid hormone carboxy-terminal level was 0.01ng/ml. We treated with it calcium gluconate infusion, low phosphorous formula milk feeding, and...
A Case of Band Heterotopia
Sung Koo Kim, Young Jun Kim, Young Ah Lee, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(7):999-1003.   Published online July 15, 1997
The “band heterotopia” or “double cortex” is a brain anomaly that is presumed to result from a premature arrest of neuronal migration. Generalized disorders of neuronal migration to the cerebral cortex have been recognized since the end of the 19th century. Recently, development of neuroimaging technique, such as MRI, have permitted easy diagnosis of generalized neuronal migration disorder. This syndrome is prevalent in females. Most...
Original Article
Seizure Types and EEG Findings of Juvenile Onset Idiopathic Generalized Epilepsy
Hyunmi Kim, Won Seop Kim, Jong Shin Kim, Kangho Cho, Ki Joong Kim, Yong Seung Hwang
Clin Exp Pediatr. 1997;40(7):991-998.   Published online July 15, 1997
Purpose : Juvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy wth generalized tonic clonic seizure(GTCS) on awakening are the three syndromes of idiopathic generalized epilepsy of adolescent onset currently included in the classification of epilepsy syndromes of the International League Against Epilepsy(ILAE). Although they differ in their predominant seizure types, the syndromes share several seizure types. Also, there are no unique electrophysiologic or genetic markers....
A Clinical Study on the Causes of Childhood Seizures According to the Age
Dong Wook Kim
Clin Exp Pediatr. 1996;39(12):1745-1752.   Published online December 15, 1996
Purpose : Although it is important to know the causes of childhood seizures according to the age, the clinical studies on this topic are rare in Korea. So, I would like to perform this clinical study to evaluate the frequencies of the age-related seizure causes in children. Methods : This study was retrospectively undertaken to evaluate the age and sex distribution,...
The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
Hyunmi Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(6):829-838.   Published online June 15, 1996
Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive...
Case Report
A Case of Hypothalamic Hamartoma with Gelastic Seizure Only
Se Wook Oh, Je Ho Cho, Sang Woo Kim
Clin Exp Pediatr. 1996;39(3):431-435.   Published online March 15, 1996
Hypothalamic hamartoma is a congenital anomaly presenting precocious puberty, gelastic seizure and mental retardation. Other possible accompanying anomalies are cleft palate, tetralogy of Fallot, skeletal malformation and anal malformation. But the patient describing here manifested gelastic seizure only with isosignal mass of 1.5cm in diameter situated just behind optic chiasm in T1WI and T2WI of MRI. His EEG showed multifocal...
Original Article
Prophylactic Effect of Diazepam to Prevent Recurrent Febrile Seiz
Seung Eun Choi, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1995;38(5):685-691.   Published online May 15, 1995
Purpose : The purpose of this study was to investigate efficacy of shortterm diazepam prophylaxis in recurrent febrile seizure. Methods : A total of 107 children admitted to the department of pediatrics, Kangdong Sacred Heart Hospital, Ballym University from 1 July 1991 to 31 December 1992, with their first or recurrent febrile seizures(one or two times), were entered in the study,...
A Clinical Study of Benign Epilepsy of Childhood with Centrotemporal Spikes
Byung Il Lee, Sang Ju Han, Hong Jin Lee, Won Il Park, Kyung Ja Lee
Clin Exp Pediatr. 1994;37(9):1251-1256.   Published online September 15, 1994
Benign epilepsy of childhood with centrotemporal spikes(BECCT) is an electroclinical syndrome characterized by noctural seizure that remit spontaneouly before adulthood, and belong to idiopathic age and location related epilepsies. We reviewed the medical records to analyse the seizure pattern, and also inspect the EEG recording to identify topography of the epileptiform discharge of 24 patient who met the following criteria: 1)presence...
The Risk of Seizure Recurrence of Pediatric Epileptic Patients While Receiving Anticonvulsant Drugs Treatment
Dae Sung Hwang, Byung Hyun Kim, Kwang Soo Oh, Yeon Kyun Oh, Hyang Suk Yoon, Jong Duck Kim
Clin Exp Pediatr. 1993;36(9):1271-1278.   Published online September 15, 1993
To evaluate the risk and factors associated with seizure recurrence on children with epilepsy while receiving the adequate anticonvulsant treament, we studied 58 patients with newly diagnosed epilepsy who were followed prospectively for a median of 26 months (range 7 to 54). The results were as follows: 1) Forty-four of the 58 patients (75.9%)had recurrence...
Brain CT Findings According to Seizure Type in Children with Seizure Disorder
Sung-Yoon Cho, Byoung-Kee Yeo, Sa-Jun Chung, Chang-Il Ahn
Clin Exp Pediatr. 1992;35(4):470-475.   Published online April 15, 1992
Detection of the organic lesion in convulsive disorder is very important for the therapeutic p-lan and the prognostic aspects. The results of brain CT in 204 children with seizure were evalu-ated in relation to the age of onset, according to seizure type, and final diagnosis of abnormal fi ndings by CT scan. The following results were obtained. 1) Out of 204 cases,...
A clinical study on neonatal seizures.
Bong Sik Kong, Ri Sa Lee, Sang Kyu Park, Ho Jin Park
Clin Exp Pediatr. 1991;34(2):230-239.   Published online February 28, 1991
Clinical observation were made on 57 cases of neonatal seizure who were admitted to the Depart- ment of pediatrics, Seoul Red Cross Hospital during the period of 7 years from Jan. 1983 to Dec. 1989. The results were as follows: 1) According to the type of delivery of neonates which showed neonatal seizure, normal vaginal delivery were 41 cases (71.9%), C-section delivary 11 cases (19.3%)...
Blood Level of Phenobarbital in Treatment of Seizure After Neonatal Asphyxia.
Ji Yean Lee, Heng Mi Kim, Doo Hong Ahn
Clin Exp Pediatr. 1989;32(9):1265-1272.   Published online September 30, 1989
In this study, we attempted to determine an optimal first dose of phenobarbital for the treatment of seizures in the asphyxiated full term neonates. Blood samples were obtained 2 to 48 hours after the administration of final effective loading dose and plasma levels were determined by the EMIT system. Four groups of neonates were studied. Six neonates (Group 1) received an intravenous loading dose of...
Clinical Observation and Electroencephalographic Findings relatee to Prognostic factor in Neonatal Seizure.
Soo Chun Kim, Jung Sam Jeon, Chong Woo Bae, Sa Joon Chung, Chang Il Ahn
Clin Exp Pediatr. 1989;32(6):816-822.   Published online June 30, 1989
To study the clinical prognosis of the neonatal seizure, we carried out a retrospective review on medical records of 40 neonates who were admitted to the Dept. of Pediatrics, Kyung Hee University Hospital between January 1979 and December 1986. The results from the study are summarized as follows 1) Male to female ratio were 1.8:1. In 50.0%(20/40) of newborn infants, neonatal seizure was detected under...
Significance of Brain CT in Children with Seizure.
Soon Ock Kang, Hyang Sook Hyun, Jee Sung Kim, Im Ju Kang
Clin Exp Pediatr. 1989;32(3):375-380.   Published online March 31, 1989
For review of diagnostic utility and significance of brain CT in children with seizure, we analysed history, EEG, neurological examination and brain CT of 130 children who had vistied our hospital from January 1984 to June 1987. The results were as follows; In this series, the frequency of abnormal brain CT was 37.7% and it’s finding kept in order of atrophy, hydrocephalus, tumor, adnormal calcification,...
Lumbar Puncture in Children whith First Seizure Associated with Fever.
S Y Chung, E S Suh, H S Kim, T W Paik, C M Kang
Clin Exp Pediatr. 1986;29(11):1225-1231.   Published online November 30, 1986
The patients included in this study were 143 children between the ages of 6 months and 6 years admitted to Pediatric department of Keimyung University Dong San Hospital with the first episode of seizure and fever in a 5 years period from July 1, 1979 to June 30, 1984. All patient underwent lumbar puncture for detection of the causes of the...
A Clinical Study on Neonatal seizures.
Chong Young Park, Myung Kul Yun, Jung Hwan Choi, Yong Seung Hwang, Chong Ku Yun
Clin Exp Pediatr. 1985;28(3):225-235.   Published online March 31, 1985
Clinical Observations were made on 96 cases of neonatal seizure who were admitted to the Department of Pediatrics, Seoul National University Hospital during the period of 5 years from June, 1979 to May, 1984. The results were as follows: 1)The most frequent cause of neonatal seizure was sepsis with or without meningitis (27.4%), and followed by hypocalcemia(23.4%)> hypoxic-ischemic brain damage(12.9%), hypoglycemia(8.0%), intracranial...
Clinical Study of Epilepsy in Children.
C J Coe, D K Han, K Y Lee, B S Kim
Clin Exp Pediatr. 1982;25(12):1234-1242.   Published online December 31, 1982
From November 1980 to June 1982, for 19 months, 636 cases of child epileptic patients were clinically investigated at Pediatric department of Yonsei Medical school, and obtained follo- wing results. 1. The epileptic patients was 4.4% of all the pediatric patients, visited or hospitalized during the same period of time. 2. Epilepsy was commoner in male child compare to female representing male to female ratio, 1.3:1. 3. The most common...
Case Report
A Case of Moyamoya Disease with Focal Seizure.
Man Gee Hong, Hak Ki Kim, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1982;25(10):1053-1057.   Published online October 31, 1982
We experienced a case of Moyamoya syndrome in a 4 year-old girl. The patient was well until 3 years of age when she first experienced numbness of the left arm. After 10 days of above episode, she had tonic-clonic movements of left sided extremities which lasted, approximately 2 hours and followed by paresis. During the following week the second attack of focal seizure followed...
Original Article
Brain Computerized Tomography (CT) in Clinical Pediatrics.
Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1981;24(5):415-422.   Published online May 15, 1981
The results of Brain CT in 93 children with seizure and or other neurologic problems are evaluated in relation to the age of onset, patients' history, final diagnosis & EEG. The overall incidence of abnormal scans were 78.5% in our series. Analysis of CT results showed that the incidence of abnormal scan was closely related to the following criteria. 1....