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- Original Article
- Evaluation of Intrauterine Growth in Neonates with Congenital Heart Disease
- Ji Hyun Yeo, Hee Jung Lee, Eun Sil Lee, Young Hwan Lee
- Clin Exp Pediatr. 2004;47(7):746-750. Published online July 15, 2004
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Purpose : Intrauterine growth retardatation(IUGR) is very important because of high mortality and morbidity in the neonatal period. We studied the intrauterine growth retardation pattern in neonates with congenital heart disease(CHD). Methods : One hundred seventeen cases with CHD(acyanotic, 73 cases; cyanotic, 44 cases) who had no other congenital malformation or maternal diseases that might affect fetal growth were enrolled in... -
- Clinical Lecture
- Pathophysiology of Persistent Pulmonary Hypertension of the Newborn
- Yong Hoon Jun
- Clin Exp Pediatr. 2004;47(7):707-715. Published online July 15, 2004
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Persistent pulmonary hypertension of the newborn(PPHN) is a disorder characterized by persistence of the pattern of fetal circulation after birth due to a sustained elevation of pulmonary vascular resistance. The two primary events in the pathophysiology of neonatal pulmonary hypertension are hypoxic pulmonary vasoconstriction(HPV) and hypoxic pulmonary vascular remodeling(HPR). Chronic hypoxemia may cause increased muscularity of the pulmonary arteries and... -
- Original Article
- Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia
- In Sook Yang, Jung Hyun Lee, Hyung Shin Lee, So Young Kim, Sung Dong Choi, In Kyung Sung, Chung Sik Chun
- Clin Exp Pediatr. 2004;47(5):527-531. Published online May 15, 2004
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Purpose : This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia. Methods : Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and... -
- Case Report
- A Case of Teratocarcinoma with Central Diabetes Insipidus
- Jong Hoon Kim, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo
- Clin Exp Pediatr. 2004;47(4):453-457. Published online April 15, 2004
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Central diabetes insipidus is a rare disorder that can result as a consequence of diverse etiologies, including malformations, autoimmune, infiltrative(e.g. neoplastic or histiocytosis) or traumatic processes, as well as mutations in the gene encoding arginine vasopressin. Idiopathic central diabetes insipidus is a diagnosis of exclusion, one that has been made less frequently through the decades. Idiopathic central diabetes insipidus in... -
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- Original Article
- Expression of Fibroblast Growth Factor Receptors at Different Stages of Differentiation in Chick Embryo Chondrocytes
- Jo Young Suh, Jong Eul Park, Woo Taek Kim
- Clin Exp Pediatr. 2004;47(4):439-447. Published online April 15, 2004
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Purpose : Proliferative chondrocytes and prehypertrophic chondrocytes secrete significant amounts of type II collagen in an extracellular matrix. In contrast, hypertrophic chondrocytes secrete type X collagen. In addition, fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) also appear to play an important role during differentiation. Accordingly, the current study identified and characterized the chondrocytes and FGFR mRNA expressed... -
- The Effect of Growth Hormone on Patients with Growth Hormone Deficiency and Idiopathic Short Stature
- Jeong Cheol Kang, Yoon Suk Choi, In Kyong Choi, Ho Sung Kim, Duk Hee Kim
- Clin Exp Pediatr. 2004;47(3):310-318. Published online March 15, 2004
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Purpose : This study was designed to evaluate the effect of growth hormones on children with growth hormone deficiency(GHD) or idiopathic short stature(ISS). Methods : Between January 1988 to July 2003, 45 patients(M26, F19) with GHD and 24 patients (M13, F11) with ISS were enrolled in this study. Height standard deviation score(Ht SDS) for chronological age(CA) and Ht SDS for bone... -
- Factors Affecting on Final Adult Height and Total Height Gain in Children with Idiopathic and Organic Growth Hormone Deficiency after Growth Hormone Treatment
- Im Jeong Choi, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2003;46(8):803-810. Published online August 15, 2003
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Purpose : The purpose of this study was to evaluate the factors affecting the final adult height and total height gain in idiopathic and organic growth hormone deficient(GHD) children after growth hormone(GH) treatment. Methods : Thirteen patients with idiopathic GHD and 22 patients with organic GHD who had been treated with GH and attained adult final height were included in this... -
- Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
- Yang Sim Koe, Soo Yeon Lee, Won Kim, Soo Chul Cho, Pyoung Han Hwang, Jung Soo Kim, Dae-Yeol Lee
- Clin Exp Pediatr. 2003;46(7):687-694. Published online July 15, 2003
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Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods :... -
- Case Report
- A Case of Cystinosis
- Min Ho Jung, Seung On Keun, Soon Ju Lee, Byung Churl Lee
- Clin Exp Pediatr. 2003;46(6):615-619. Published online June 15, 2003
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Cystinosis, an autosomal recessively inherited lysosomal storage disease, results from impaired transport of the amino acid cystine out of cellular lysosomes. The consequent accumulation and crystallization of cystine destroys tissues, causing growth retardation, Fanconi syndrome, renal failure, eye problems, and endocrinopathies. The gene for cystinosis, CTNS, was mapped to chromosome 17p13. The diagnosis of cystinosis was made by measuring the... -
- A Case of Partial Inverted Duplication of Chromosome 7q
- Hyun Ji Kim, So Young Lee, Mi Young Kim, Chung Sun Baek, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
- Clin Exp Pediatr. 2003;46(5):510-513. Published online May 15, 2003
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Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long... -
- Original Article
- Overnight Growth Hormone Secretions and Sleep Patterns in Idiopathic Short Stature Children
- Sang Young Seo, Kee Hyoung Lee, Baik Lin Eun, Chang Sung Sohn, Young Chang Tockgo, Chol Shin, Baek-Hyun Kim
- Clin Exp Pediatr. 2003;46(4):363-369. Published online April 15, 2003
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Purpose : Pharmacologic provocation test of growth hormone(GH) is a non-physiologic method and has several limitations for diagnosing growth hormone(GH) deficiency. Spontaneous GH release studies could be important in understanding the pathophysiology of children with poor growth but normal responses to GH provocation tests. Also, the relationship between nocturnal GH secretions and sleep patterns in short stature children is poorly... -
- Endocrine Function and Growth in Children with Craniopharyngioma
- Yoo Mi Chung, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2003;46(3):277-283. Published online March 15, 2003
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Purpose : Craniopharyngiomas are often accompanied by severe endocrine disorders. Although there is universal growth hormone deficiency(GHD), the resulting growth pattern is very heterogeneous. We report the growth and endocrine outcome of 44 children with craniopharyngioma, with emphasis on initial symptoms, growth before and during growth hormone(GH) treatment and spontaneous growth in spite of GHD. Methods : We performed a... -
- Hypoxia Induced Expression of Vascular Endothelial Growth Factor in Rat Pulmonary Artery Smooth Muscle Cells
- Un Seok Nho, Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
- Clin Exp Pediatr. 2003;46(2):167-172. Published online February 15, 2003
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5% CO2-95% air atmosphere. The smooth muscle cells were confirmed by immunostaining with smooth muscle myosin and α-smooth muscle actin antibodies. The VEGF gene expression in the hypoxic group was compared with the one in control the group as well as the one in the starved group by RT-PCR and Northern blot hybridization. Results : There was no statistically significant difference... -
- Thymus Size and Its Relationship to Perinatal Diseases; Respiratory Distress Syndrome and Intrauterine Growth Retardation
- Sun Mi Chung, Woo Taek Kim
- Clin Exp Pediatr. 2002;45(7):855-861. Published online July 15, 2002
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Purpose : Thymus size can be affected by several factors and perinatal diseases can be estimated by its size. The purpose of this study was to search for a relationship between cardiothymic/ thoracic(CT/T) ratio and perinatal diseases such as neonatal respiratory distress syndrome(RDS) and intrauterine growth retardation(IUGR) by measuring the width of the cardiothymic shadow at the level of the... -
- Type 2 Diabetes Mellitus in Children
- Jee Min Park, Eun Gyong Yoo, Duk Hee Kim
- Clin Exp Pediatr. 2002;45(5):646-653. Published online May 15, 2002
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Purpose : The incidence of type 2 diabetes mellitus in children has been increasing worldwide recently, which is thought to be related to the increasing prevalence of obesity. We investigated to evaluate the incidence and the characteristics of type 2 diabetes mellitus in children and also analysed the relationship between intrauterine growth retardation and type 2 diabetes mellitus. Methods :... -
- The Study of Serum Vascular Endothelial Growth Factor in the Acute Febrile Phase of Kawasaki Disease
- Minshik Kim, Kyungsook Kim
- Clin Exp Pediatr. 2002;45(1):114-119. Published online January 15, 2002
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Purpose : Kawasaki Disease(KD) is a febrile disease with acute multisystemic vasculitis associated with early development of acute myocarditis and coronary artery abnormalities. The cause and etiologic agents are still unknown. Clinical studies suggest that KD is one of the autoimmune disorders caused by infectious agent, but this is not proved yet. The study was performed to investigate the levels of vascular endothelial growth... -
- Growth and Neurodevelopmental Outcome at 15 Months of Corrected Age in Very Low Birth Weight Infants with Chronic Lung Disease
- Seon Young Kim, Chang Yee Cho, Young Youn Choi
- Clin Exp Pediatr. 2001;44(10):1112-1118. Published online October 15, 2001
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Purpose : This study was performed to compare the growth and neurodevelopmental outcome at 15 months of corrected age in very-low-birth weight infants between chronic lung disease(CLD) group and the control group. Methods : Very-low-birth-weight infants who were admitted and survived in the NICU(neonatal intensive care units) of Chonnam Univeristy Hospital from Jan. 1997 to Jan. 2000 were divided into... -
- Case Report
- Two Cases of Growth Hormone Therapy in Idiopathic Dilated Cardiomyopath
- Jeong Won Shin, Hong Ryang Kil, Jae Hong Yu
- Clin Exp Pediatr. 2001;44(8):942-947. Published online August 15, 2001
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Growth hormone receptor gene is expressed in the myocardium and growth hormone(GH) administration has been shown to increase cardiac insulin-like growth factor-I(IGF-1) contents. The cardiac myocyte express IGF-I receptors and IGF-I promotes cardiac hypertrophy. Furthermore GH therapy has been reported to have beneficial effects in the treatment of dilated cardiomyopathy in adults. We have studied the effect of short term... -
- Original Article
- Growth Hormone Receptor Mutation and Partial Growth Hormone Insensitivity in Children with Idiopathic Short Stature
- So Chung Chung, Ran Namgung, Duk Hee Kim
- Clin Exp Pediatr. 2001;44(8):922-935. Published online August 15, 2001
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Purpose : Children with idiopathic short stature(ISS) are classified on the basis of exclusion criteria. Short stature with normal or increased circulating growth hormone(GH) and low IGF-I levels indicates that partial growth hormone insensitivity(GHI) may play a role in ISS. The present study was performed to investigate whether partial GHI is observed in children with idiopathic short stature and whether... -
- Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
- Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 2001;44(6):635-641. Published online June 15, 2001
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Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded... -
- Case Report
- A Case of Apert`s Syndrome(Acrocophalosyndactyly) with Fibroblast Growth Factor Receptor 2 Exon Ⅲa Mutation
- Hyung Su K, Pyl Soon Yang, Jee Yeoun Kang, Ok Young Kim, Chul Hae Ku, Wha Mo Lee
- Clin Exp Pediatr. 2000;43(7):1006-1011. Published online July 15, 2000
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Apert syndrome is an uncommon congenital disorder characterized by malformation of the skull in association with symmetrical syndactyly of both hands and feet. This syndrome is autosomal dominant. The original description was presented by Apert in 1906. Since then more than 200 cases have been reported in the world. Recently, we experienced a case of newhorn male infant with congenital... -
- Original Article
- Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Infants
- Yoon Ki Kang, Dae-Yeol Lee
- Clin Exp Pediatr. 2000;43(7):967-973. Published online July 15, 2000
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Purpose : Insulin-like growth factor(IGF-I) and IGF binding protein(IGFBP)-3 is thought to play an important role in fetal erythropoiesis. The objective of this study was to establish a relation between IGF-I, free IGF-I, IGFBP-1, and -3 with hemoglobin level in healthy term, 3-month, and 12-month old infants. Methods : Healthy term infants(n=20) were enrolled at birth, as well as 3 months(n=30) and 12 months(n=30) of... -
- Effect of Growth Hormone Secretion on Serum Concentration of Leptin
- Se-Eun Kim, Jeong-Nyeo Lee, Sang-Ook Nam, Woo-Yeong Chung
- Clin Exp Pediatr. 2000;43(7):959-966. Published online July 15, 2000
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Purpose : To investigate the effect of growth hormone(GH) secretion on serum concentration of leptin, we evaluated the differences in serum concentration of leptin between patients with growth hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the relationship between GH and serum leptin level. Also, we analyzed the correlation between serum concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth... -
- Changes in Fat Tissue and Growth Hormone Receptor mRNA after Growth Hormone Therapy
- Hye Jung Shin, Duk Hee Kim, So Chung Chung, Kyungyoon Kam
- Clin Exp Pediatr. 2000;43(2):247-252. Published online February 15, 2000
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Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We investigated the changes in fat tissue and GH receptor mRNA in adipose tissue... -
- Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
- Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
- Clin Exp Pediatr. 1999;42(7):991-1002. Published online July 15, 1999
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Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)... -
- Final Height in Idiopathic Growth Hormone(GH) Deficient Children Treated with GH
- Byung Churl Lee
- Clin Exp Pediatr. 1999;42(6):852-857. Published online June 15, 1999
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Purpose : Improved adult height is a major goal in the treatment of children with short stature due to GH deficiency(GHD). The purpose of this study was to evaluate final height in idiopathic GH deficient children after long-term GH treatment Methods : GHD was diagnosed in 9 male patients by at least two stimulation tests(maximum GH level≤5ng/ml). Other pituitary functions were... -
- Serum Levels of Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Protein-3 between Short Children with or without Intrauterine Growth Retardation
- Kye Shik Shim, Se Young Kim, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 1999;42(3):390-396. Published online March 15, 1999
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Purpose : Postnatally, 20% of children with intrauterine growth retardation(IUGR) has no catch- up growth, This might be dependent on the serum level of Insulin-like growth factor I(IGF-I), resulting in shortness. We measured serum levels of IGF-I and Insulin-like growth factor binding protein-3(IGFBP-3) in children with IUGR and normal short stature variants(NSSV) to observe whether they play a role in... -
- Case Report
- A Case of Ulcerative Colitis with Growth Disturbance
- Ki Hyun Jeon, Dong Hyun Choi, Eun Yung Seol, Kyung Eun Oh, Mun Ki Cho, Chul Son, Jong Soon Kim
- Clin Exp Pediatr. 1999;42(2):289-295. Published online February 15, 1999
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Ulcerative colitis is a chronic relapsing inflammatory disease of the colonic and rectal mucosa, which affects children as well as adults. Inflammation caused by ulcerative colitis is limited to the colon and rectum, to the mucosa and submucosa, and is involved continuously, with varying degrees of ulceration, hemorrhage, edema, and regenerating epithelium. Ulcerative colitis most commonly presents with the onset... -
- A Case of FGFR2 Exon Ⅲc Mutation in Crouzon Syndrome
- Seon Chan Bae, Eun Ha Lee, Moon Sung Park, Si Houn Hah, Chang Ho Hong
- Clin Exp Pediatr. 1998;41(12):1717-1721. Published online December 15, 1998
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Crouzon syndrome, an autosomal dominant disorder, has characteristic features of craniosynostosis, hypertelorism, exophthalmos, maxillary hypoplasia and relative mandibular prognathism. Mutations of fibroblast growth factor receptor 2(FGFR2) gene are associated with craniosynostotic conditions, such as Crouzon syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome, Apert syndrome and Beare-Stevenson cutis gyrata. We found one child with common morphological features of Crouzon syndrome. Interestingly, she... -
- Original Article
- Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight
- Hye Young Kim, Dae Yeol Lee, Soo Chul Cho
- Clin Exp Pediatr. 1998;41(11):1484-1490. Published online November 15, 1998
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Purpose : Insulin-like growth factors(IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein(IGFBP) which regulates the availability of IGFs to their specific target tissue. This study was performed to examine the relationships between birth weight and IGFs, insulin and growth hormone in the sera of cord blood... -
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