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Original Article
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Case Report
A Case of Newborn Sepsis Caused by Streptococcus pneumoniae
Eun Ha Choi, Seong Hee Jang, Eun Sil Dong, Young Min Ann
Clin Exp Pediatr. 1995;38(12):1690-1693.   Published online December 15, 1995
Systemic infection due to Streptococcus pneumoniae is a serious, albeit rare disease in the neonatal period. There is no case of pneumococcal sepsis reported in Korea. The results of epidemiologic studies suggest that the majority of infants with pneumococcal septicemia acquire the microorganisms either by the ascending route or during passage throught the birth canal. The mortality is high in...
Original Article
Riboflavin Status of Normal Newborn Infants and the Changes of Riboflavin During Phototherapy in Hyperbilirubinemic Newborn Newborn Infants
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1995;38(9):1185-1192.   Published online September 15, 1995
Purpose : Riboflavin is the most important water soluble vitamin in infant nutrition. Riboflavin is converts to flavin mononucleotide (FMN), Flavin adenine dinucleotide(FAD) and then, participiates in the metabolism of energy, protein cellular oxidation-reduction reactions as a cofactor of reactions. Also riboflavin, a light sensitive vitamin, has a maximum absorption spectrum at a wave length similar to that at which...
Case Report
A Case of Cardiac Tumor Associated with Tuberous Sclerosis in Newborn
Yong Myung Cho, Woo Seok Kim, Nam Soo Park, Un Jun Hyoung, Eun Ryyoung Kim, Je Geun Chi
Clin Exp Pediatr. 1995;38(2):275-279.   Published online February 15, 1995
Symptomatic primary heart tumors are rare in newborn. Cardiac rhabdomyoma is the most common lesion of the primary heart tumors and over half of them are related to kthe tuberous s clerosis. We described a case of cardiac rhabdomyoma, in a 2 day-old female newborn who presented with dyspnea and cyanosis. A 2D Echocardiogram demonstrated two masses; one is in...
Original Article
Clinical Study of Transient Tachypnea of the Newborn
Young Soo Kweon, Soo Jin Jung, Chang hee Han, Hae Woon Jang, Ki Ho Kim
Clin Exp Pediatr. 1995;38(1):10-19.   Published online January 15, 1995
Transient tachypnea of the newborn(TTN) is a benign self-limited disease characterized by early onset and rapid recovery of tachypnea although it may occasionally have a more prolonged and protracted course. A retrospective clinical study was mad on 29 neonates with TTN admitted to NICU of Pohang St. Mary's Hospital from January 1992 to June 1993. The results were as follows: 1) TTN(36.2%) was...
Causes of Anemia Less Than 7 Days of Age
Man Seong Ko, Jina Sohn, Jae Wook Ko, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1994;37(12):1725-1731.   Published online December 15, 1994
Purpose : Within a few days from birth, newborn infants are under conitions of normal physiologic changes. During this period, the certain newborn infants are confronted with a severe life-threatenling hematologic problems such as anemia. Therefore, prompt diagnosis of anemia and accurate identification of underlying causes would rather be essential to provide appropriate menagement. Methods : Eighty three newborn infants who...
Effect of IVIG Treatment on Renal Function in Neonates
So Yeon Kim, Haeng Mi Kim
Clin Exp Pediatr. 1994;37(10):1414-1419.   Published online October 15, 1994
This study was conducted to evaluate the effect of intraveneous immunoglobulin(IVIG) infusion on renal function in neonates. IVIG has provided quite safe in neonates given therapeutic doses. But nephrotoxicity is not a recognized adverse events of IVIG therapy, only several previous adult cases having been described. A total twenty five neonates suspected sepsis was randomely assigned to IVIG(n=12) or control(n=13) group. Neonates...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with Perinatal Asphyxia and Hypoxic-Ischemic Encephalopathy with Doppler Technique
Kook In Park, Dong Kwan Han, Joon Soo Lee, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(9):1196-1204.   Published online September 15, 1994
Fifty-three full-term, preterm, term-SGA newborn infants with perinatal asphyxia and 16 full-term infants with hypoxic-ischemic encephalopathy were studied with color Doppler songraphy to assess the postnatal change of the cerebral blood flow velocity(CBFV) longitudinally. A control group of 81 healthy infants also had CBFV recordings during the 1st week of life. Pourcelot Resistance index(PI) and area under the velocity curve(AUVC)...
A Study on Evolution of Lipoportein(a) in Newborns
Keun Haeng Cho, Young Sook Hong, Soo Won Lee, Soon Kyum Kim, Young Chang Tockgo, Han Kyeom Kim
Clin Exp Pediatr. 1994;37(8):1078-1091.   Published online August 15, 1994
Lipoprotein(a) [Lp(a)] is considered an additional, independent and largely genetically determined risk factor for the development of premature coronary heart disease. Furthermore abnormal plasma lipoprotein patterns have been associated with increased risk for developing coronary heart disease. Among these lipoproteins, an increased concentration of serum Apo B and decreased level of Apo A are considered as major risk factors, together...
Incidence and Perinatal Risk Factors of Respiratory Distress Syndrome of Newborn
Yun Sil Chang, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1994;37(8):1065-1077.   Published online August 15, 1994
Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn. The total incidence of RDS among all the newborns(inborn)was 1.77%....
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Normal Values for Neonatal Periumbilical Skin Length
Young Pyo Chang, Hyung Suk Lim, Hye Won Park, Woong Huem Kim, Hee Ju Kim
Clin Exp Pediatr. 1994;37(7):924-927.   Published online July 15, 1994
Malformations of umbilicus are feature of many dysmorphic syndromes and the measurement of periumbilical skin length should be considered as the basic step in the description of the umbilical malformations. So, we measured the periumbilical skin length in the 103 normal neonates and obtained the following results. 1) The means(+SD) of the periumbilical skin length were the 11.7mm(+3.0)in the cranial site...
Clinical Observation of Neonatal Group B β-Hemolytic Streptococcal Meningiti
Yeon Chung Chung, Mi Won Kim, Yong Kyu Lee, Yun Jong Kang, Jung Wan Seo, Jin Keun Chang
Clin Exp Pediatr. 1994;37(3):347-355.   Published online March 15, 1994
Neonatal meningitis caused by the Group Bβ-hemolytic streptococcus was first reported in 1958. In recent years this organism has assumed major importance in the etiology of neonatal infection. In Korea, this organism is likely to play an increasing role in neonatal infection. So this investigation was designed to report the 9 cases of Group B β-hemolytic streptococcus infected neonates admitted to...
Clincal Study on 12 Cases of Neonatal Group B β-Hemolytic Streptococcal Meningitis
Won Jin Kim, Sang Woog Lee, Sang Lak Lee, Myung Sung Kim, Chin Moo Kang
Clin Exp Pediatr. 1993;36(11):1507-1515.   Published online November 15, 1993
A clinical study was made on 12 cases of neonatal Group Bβ-hemolytic streptococcal(=GBS)meningitis, who were admitted to the department of Pediatrics, Dong-San Hospital, Keimyung University during the period of 3 years from Aug 1989 to Jul 1992. The following results were obtained 1) GBS was cultured in 12 cases(57.1%) among 21 neonatal meningitis admitted during the same period. 2) Male and female ratio...
Outcome in Infants of Mothers with Systemic Lupus Erythematosus
Chang Ryul Kim, Young Pyo Chang, Hee Seop Kim, Mi Jung Kim, Byung Il Kim, Jung-Hwan Choi, Chong Ku Yun, Bo Hyun Yoon, Hee Chul Syn, Syng Wook Kim, Seon Yang Park, Hahng Lee
Clin Exp Pediatr. 1993;36(6):791-804.   Published online June 15, 1993
A large proportion of patients with systemic lupus erythematosus(SLE) are women of reproductive age. Their fetal outcome is undoubtedly less favourable than in haelthy women. Although there is no evidence of an increase in congenital anomalies, increased frequencies of miscarriage, stillbirth, growth retardation, and preterm delivery are recognized It mainly depends on the compromise of uteroplacental circulation such as renal...
The Relationship Between Neonatal Hypoglycemia and Newborn Iron Status in Hypoglycemic Large-for-Gestational Age Infants
Myung Ja Yun, In Ho Song, Hye Lim Jung, Dong Hyuck Kum
Clin Exp Pediatr. 1992;35(12):1667-1673.   Published online December 15, 1992
We assessed the relationship between neonatal hypoglycemia and newborn iron status in hypoglycemic large-for-gestational age, euglycemic large for gestational age and euglycemic appropriate for gestational age infants that were admitted to the department of Pediatrics, Koryo General Hospital from July 1989 to June 1990. The results are as follows; 1) The incidence of large for gestational age infants was 3.3% (32...
The Significance of Nucleated Red Blood Cell Counts in Various Conditions Associated with Acute or Chronic Perinatal Asphyxia
Suck Kyu Hur, Moon Sang Park, Mee Kyung Namgoong, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim, Myung Seo Kang
Clin Exp Pediatr. 1992;35(11):1514-1519.   Published online November 15, 1992
This study was conducted to find out the significance of nucleated red blood cell (NRBC) in neonates, especially associated with acute or chronic perinatal asphyxia. So, we compared NRBC counts in various neonatal groups, such as normal newborn, small for gestational age (SGA), premature, acute perinatal asphyxia, & hyaline membrane disease (HMD). In the first day of life, we examined...
Children with Delayed Speech Development
Sang Kee Park, Ho Sung Yoo, Yeong Bong Park
Clin Exp Pediatr. 1992;35(9):1236-1242.   Published online September 15, 1992
The antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase and the lipid peroxidation were assayed in erythroctyes from the cord blood of 25 fullterm newborn infants and their maternal blood abtained immediatedly after normal delivery. Superoxide dismutase and catalase activites in cor blood erythroctytes were significantly lower when compared with their mothers, but glutathione peroxidase activities were not significantly lower....
Postnatal change of Atrial natriuretic peptide in newborn Infants
Eun Sook Kim, Heng Mi Kim
Clin Exp Pediatr. 1992;35(9):1193-1197.   Published online September 15, 1992
Atrial natriuretic peptide(ANP)has been described as a part of the regulatory system of volume homeostasis. The role of ANP in postnatal volume hmestasis was investigated in 27 normal newborn infants during the early postnatal period. Plasma Mean plasma concentration of plasma ANP was 24.7¡¾13.8 pg/13.8pg/ml on the 1st day, 56.2¡¾60.0pg/ml on the 3-5th day and 35.0¡¾22.0pg/ml on the 7th day....
A Comparison of Reagent Test Strip-photometer and Laboratory Plasma Glucose Values in Newborns
Jin Kyung Kim, Myung Chul Hyun, Sang Bum Lee, Heng Mi Kim
Clin Exp Pediatr. 1992;35(8):1501-1058.   Published online August 15, 1992
Although reagent test strip-photometer method is frequently used to estimate plasma glucose values in nurseries, the accuracy in newborns have not been evaluated previously. In this study values of 44 samples of laboratory glucose were compared with values simultaneously obtained by reagent test strip-photometer. Laboratory values were determined by glucose oxidase method using veous plasma. Reagent test strip-photometer values were determined...
Clinical Observation on Newborn using Artificial Ventilator
Hyun Seung Park, Myung Ik Lee, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1992;35(3):322-329.   Published online March 15, 1992
Retrospective clinical analysis of 5 and a half yeas experience with artificial ventilaion on 187 neonas in NICU of National Medical Center, from Jan. 1985 to Dec. 1990, was done. The results were as follows; 1) Number of patients, who required respiratory therapy with aritificial ventilation, was 187 and the percentage of these patients to all hospitalized neonates was 11.4%. 2) Number...
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with the Doppler Technique
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee, Jin Suk Suh, Myung Joon Kim
Clin Exp Pediatr. 1992;35(1):60-68.   Published online January 15, 1992
Eighty-one asymptomatic preterm, term-SGA, and full term infants who were delivered at Yonsei University Severance Hospital from January to July 1990 were studied with color duplex imaging doppler sonography to assess the postnatal changes of the cerebral blood flow velocity longitudinally. Pulsatility index (PI) and area under the velocity curve (AUVC) were calculated to quantitate changes in anterior cerbral artery blood...
Mechanical ventilator care in the newborn infants.
Young Pyo Chang, Yong Won Park, Won Soon Park, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(11):1526-1533.   Published online November 30, 1991
The widespread introduction of mechanically assisted ventilation into the neonatal intensive care during the 1960s substantially improved the outcome of sick newborn infants, particularly those with respiratory disorders. We studied the clinical features of 82 neonates, who were treated with mechanically assisted ventilation in Neonatal Intensive Care Unit (NICU) at Seoul National Univer- sity Children’s Hospital from January 1986 to August 1989 (the second...
A case of pulmonary vascular air embolism in the newborn.
Won Soon Park, Beom Soo Park, Hye Kyung Han, Jung Hwan Choi, Chong Ku Yun, Kyoung Mo Yeon, Je Geun Chi
Clin Exp Pediatr. 1991;34(10):1422-1427.   Published online October 31, 1991
Pulmonary vascular air embolism is a rare, and almost invariably fatal complication of positive pressure ventilation of newborn infants. There have only been 53 cases described in the world literature to date. We have experienced a case of pulmonary vascular air embolism in a premature newborn as a complication of mechanical ventilation during the course of respiratory distress syndrome. The pathophysiology and clinical characteristics of...
Neonatal hypocalcemia: clinical manifestations and prognosis.
Jeong Lim Kim, Heung Dong Kim, Chang Jun Coe
Clin Exp Pediatr. 1991;34(7):912-920.   Published online July 31, 1991
Hypocalcemia during the newborn period is relatively common particularly in infants with predis- posing factors, such as prematurity, low birth weight, birth asphyxia and diabetic mothers and it is often manifested by various clinical findings. Some authors have reported that in some cases of the neonatal hypocalcemia, there were neurologic deficits such as irritability and convulsion, and neur- ologic sequelae on follow up. It...
The normal values of platelet count, mean platelet volume and platelet distribution width in the normal newborn, small for gestational age and premature neonates.
Eun Kyung Oh, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1991;34(3):340-347.   Published online March 31, 1991
The importance of establishing authentic normal platelet count, mean platelet volume and platelet distribution width in the newborn has been emphasized, but they have not been firmly established. We have presented values for platelet count, mean platelet volume and platelet distribution width in the venous blood of term, small for gestational age and premature neonates at postnatal day 1 and 7. The results were...
Changes in Auditory Brainstem Reponses (ABR) in Severe Hyperbilirubinemic Neonates with Transient Bilirubin Encephalopathy.
Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1990;33(9):1216-1222.   Published online September 30, 1990
Many authors have reported alterations in the ABR in severe hyperbilirubinemia and ABR is an effective non-invasive method of assessing the functional status of the auditory nerve and brainstem sensory pathway in the management of neonatal hyperbilirubinemia. Perlman et al reported that jaundice in the early neonatal period is associated with significant transient aberration of ABR, suggestive of a transient bilirubin encephalopathy (TBE). And...
A Clinical Observation of Neonatal Hyperbilirubinemia due to ABO Incompatibility.
Mi Jung Koh, Young Kyun Lee, Jin Hong Park, Yeon Kyun OH
Clin Exp Pediatr. 1990;33(9):1194-1201.   Published online September 30, 1990
A clinical and statistical study was performed on 43 neonates of hyperbilirubinemia due to ABO incompatibility who were admitted to department of pediatrics of Won-kwang University hospital from May 1987 to June 1988. The following results were obtained: 1) The incidence of hyperbilirubinemia within 48 hrs were 30.3% in the incompatible group and 10. 2% in the compatible group. So, hyperbilirubinemia was appeared earlier in...
Dubowitz Neurologic Examination in Normal Neonates.
Young Soo Lee, Soh Yeon Kim, Dong Chul Park, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(7):977-988.   Published online July 31, 1990
With the improvement in survival rate in high risk infants in the neonatal intensive care unit, there is rising concern about the neurologic sequelae in these infants. In order to evaluate the neur- ologic examination in normal neonates, 400 normal newborns were evaluated for a duration of 6 months from Mach 1989 to August 1989. Neonates greater than 37 weeks gestational age, birth weight...