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Review Article
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Ho Joon Im, Kyung-Nam Koh, Jong Jin Seo
Clin Exp Pediatr. 2015;58(6):199-205.   Published online June 22, 2015

Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT from an unrelated donor (URD)....

Original Article
Clinical features of infantile hepatic hemangioendothelioma
Eun Hee Kim, Kyung Nam Koh, Meerim Park, Bo Eun Kim, Ho Joon Im, Jong Jin Seo
Clin Exp Pediatr. 2011;54(6):260-266.   Published online June 30, 2011
Purpose

Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy. We conducted this study to review our clinical experience of patients with IHHE and to suggest management strategies.

Methods

We retrospectively analyzed the medical records of 23 IHHE patients (10 males, 13 females) treated at the Asan Medical Center between 1996 and 2009.

Results

Median age at diagnosis was...

Prognostic significance of minimal residual disease detected by a simplified flow cytometric assay during remission induction chemotherapy in children with acute lymphoblastic leukemia
Kyung Nam Koh, Meerim Park, Bo Eun Kim, Ho Joon Im, Chan-Jeoung Park, Seongsoo Jang, Hyun Sook Chi, Jong Jin Seo
Clin Exp Pediatr. 2010;53(11):957-964.   Published online November 30, 2010
Purpose

Our study attempted to determine the prognostic significance of minimal residual disease (MRD) detected by a simplified flow cytometric assay during induction chemotherapy in children with B-cell acute lymphoblastic leukemia (B-ALL).

Methods

A total of 98 patients were newly diagnosed with precursor B-ALL from June 2004 to December 2008 at the Asan Medical Center (Seoul, Korea). Of those, 37 were eligible for...

Case Report
A case of anemia caused by combined vitamin B12 and iron deficiency manifesting as short stature and delayed puberty
Seung Min Song, Keun Wook Bae, Hoi-Soo Yoon, Ho Joon Im, Jong-Jin Seo
Clin Exp Pediatr. 2010;53(5):661-665.   Published online May 31, 2010

Anemia caused by vitamin B12 deficiency resulting from inadequate dietary intake is rare in children in the modern era because of improvements in nutritional status. However, such anemia can be caused by decreased ingestion or impaired absorption and/or utilization of vitamin B12. We report the case of an 18-year-old man with short stature, prepubertal sexual maturation, exertional dyspnea, and severe...

Original Article
Ototoxicity in children receiving cisplatin chemotherapy
Hee Jin Jang, Hyung Rae Cho, Jae Hee Lee, Kun Yuk Bae, Jong Jin Seo, Hyung Nam Moon, Ho Joon Im
Clin Exp Pediatr. 2010;53(2):210-214.   Published online February 15, 2010
Purpose : Cisplatin is highly effective for the treatment of solid tumors in children. However, the clinical use of cisplatin is limited by its ototoxicity. The aim of this study was to evaluate the ototoxicity in children treated with cisplatin. Methods : We performed a single institution retrospective analysis of pediatric oncology patients who received cisplatin therapy between January 2001 and...
Outcome and risk factors of pediatric hemato-oncology patients admitted in pediatric intensive care unit
Bo Eun Kim, Eun Ju Ha, Keun Wook Bae, Seongguk Kim, Ho Joon Im, Jong Jin Seo, Seong Jong Park
Clin Exp Pediatr. 2009;52(10):1153-1160.   Published online October 15, 2009
Purpose : To evaluate the risk factors for mortality and prognostic factors in pediatric hemato-oncology patients admitted to the pediatric intensive care unit (PICU). Methods : We retrospectively reviewed the medical records of pediatric hemato-oncology patients admitted at the PICU of the Asan Medical Center between September 2005 and July 2008. Patients admitted at the PICU for perioperative or terminal...
Case Report
A Case of Nasal T/NK-cell Lymphoma
Jung Bok Lee, In-sang Jeon, Ho Joon Im, Young Ha Oh, Ji Hye Kim
Clin Exp Pediatr. 2003;46(12):1266-1270.   Published online December 15, 2003
The advance of the immunobiology clarifies the nature of non-Hodgkin's lymphoma(NHL). In addition the proceed in the immunophenotyping renders the classification of NHL. According to the Revised European American Lymphoma(REAL) classification, classified by the etiologic factors, molecular biological characteristics, immunophenotype, cytogenetics and histologic feature, nasal T/NK-cell lymphoma(=angiocentric lymphoma) belongs to the category of peripheral T-cell and natural killer cell lymphoma....
Original Article
Analysis of Treatment in Pediatric Germ Cell Tumor
Young Dai Kim, Su Hyun Kim, Ki Joong Kim, Ho Joon Im, Hahng Lee
Clin Exp Pediatr. 2002;45(1):103-108.   Published online January 15, 2002
Purpose : This report is an analysis of our experience with surgery, multi-agent chemotherapy and radiotherapy, in pediatric germ cell tumors(GCTs). Methods : This report included all children(age < 15 years) who were registered between November 1985 and May 2001 with a histologically confirmed diagnosis of GCT and received surgery, chemotherapy and radiotherapy. Retrospective analysis of the medical records of these patients was performed. In...
Case Report
Two Cases of Infantile Hemangioendothelioma of the Liver in Neonates
Soo Jin Han, Soo Shin Cho, Gwang Hoon Lee, Ho Joon Im, Seong Ho Kim, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 2001;44(12):1469-1474.   Published online December 15, 2001
Infantile hemangioendothelioma(IHE) of the liver is a rare benign vascular tumor that presents most commonly in infants before the age of 6 months. IHE presents as abdominal mass, cutaneous hemangiomas, unexplained jaundice, bleeding disorders, or congestive heart failure. Death often results from congestive heart failure despite appropriate treatment with digoxin and diuretics. IHE also is associated with Kasabach-Merritt syndrome, anemia,...
Original Article
Comparison of Brainstem Auditory Evoked Response in Normal Infants, Male and Female, Right and Left Ear
Soo Jin Han, Soo Shin Cho, Kang Ho Cho, EeIl Ryoo, Gwang Hoon Lee, Ho Joon Im, Kye Hwan Seol, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 2001;44(11):1243-1248.   Published online November 15, 2001
Purpose : Brainstem auditory evoked response(BAER) is used as screening test for hearing disorders, damages of the central nervous system and congenital anomalies. We studied the difference values according to gender and stimulation sites in normal full-term infants. Methods : We performed BAER in 38 male and 28 female normal full-term infants, delivered in the Gil Medical Center, Gachen Medical School,...
Treatment Outcomes in Children with High-Risk Acute Lymphoblastic Leukemia
Kyu Chang Park, Ho Joon Im, Sang Yun Ahn, Hahng Lee
Clin Exp Pediatr. 1999;42(3):383-389.   Published online March 15, 1999
Purpose : The survival rate of those with acute lymphoblastic leukemia(ALL) has been affected by several prognostic factors and previous reports show that a 4-year event-free survival(EFS) for high-risk(HR) group(Age≥10 years and/or WBC≥50,000/mm3 at diagnosis) was approximately 64%. We analyzed treatment outcomes and risk factors in HR-ALL. Methods : Medical records of 27 patients with HR-ALL diagnosed between May, 1985 and...
A Clinical Study of Survival Rate and Prognostic Factors in Advanced Neurobalstoma in Children
Seung Yang, Ho Joon Im, Nam Su Kim, Hahng Lee
Clin Exp Pediatr. 1998;41(5):684-694.   Published online May 15, 1998
Purpose : Despite the use of improved therapeutic modalities, long-term survival remains poor in patients in stage Ⅲ or Ⅳ of neurobalstoma and for over 1 year olds at diagnosis. We evaluated the long-term survival rate and related prognostic factors in advanced neuroblastoma. Methods : Twenty-nine children diagnosed with stage Ⅲ or Ⅳ neuroblastoma after 1 year of age, between May...
Study on the Frequency of Right Bundle Branch Block After Surgical Closure of Ventricular Septal Defect
Ho Joon Im, Jin Nyoung Park, Nam Su Kim, Jeh Hoon Shin, In Joon Seol, Soo Ji Moon
Clin Exp Pediatr. 1993;36(1):88-93.   Published online January 15, 1993
The purpose of this study is to evaluate the ventricular conduction abnormalities, especially RNNN, observed electrocardiographically after sugical closure of VSD. The present study population consists of 92 patients with VSD who were surgically corrected at the Hanyang University Hospital during 6 years period from Jan. 1985 to Dec. 1990. We reviewed their clinical records including surgical notes and EKG findings...
Case Report
A Case of Video Game Epilepsy
Jin Nyoung Park, Ho Joon Im, Sung Lae Park, Jeh Hoon Shin, In Joon Seol, Soo Ji Moon
Clin Exp Pediatr. 1992;35(12):1756-1761.   Published online December 15, 1992
Video game epilepsy is a photic induced sensory evoked seizure, and the seizure occurs only following a specific program of video game. We experienced a case of video game epilepsy in a 12 year old boy who presented with seizure during video game, and showed photoconvulsive response on photic stimulated EEG.
Original Article
A clinical study on twin.
Ho Joon Im, Sang Yoon Ahn, In Joon Seol, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1991;34(5):621-628.   Published online May 31, 1991
Among the total of 17,991 newborns delivered at Hanyang University Howpital from January 1980 to December 1989, a clinical study was performed on 277 twin pregnancies. The results of the study were as follows: 1) The incidence of twins was 1:64.9. 2) The average male-female sex ratio of twins was 1:1.1, total same sex pairs rate was 79.4% (male-male & female-female) and different sex rate was 20.6%. 3) The...
A case of interstitial pulmonary fibrosis.
Hak Won Kim, Ho Joon Im, In Joon Seol, Ha Baik Lee, Hahng Lee, Seok Chol Jeon, Moon Hyang Park
Clin Exp Pediatr. 1991;34(1):107-114.   Published online January 31, 1991
Interstitial pulmonary fibrosis is a rare, diffuse lug disease which has a tendency to destroy the lung architectures by consequent healing with progressively severe fibrosis. We report with a brief review of literature, one case of a 7-year old female with the typical pictures of interstitial pulmonary fibrosis, histologically on open lung biopsy, and clinically presenting with chronic respiratory difficulty but without definite symptoms...
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