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Volume 47(11); Nov 2004
Medical Lecture Course
Role of Mast Cells in Allergic Inflammation and Innate Immunity
Kangmo Ahn
Korean J Pediatr. 2004;47(11):1137-1141.   Published online November 15, 2004
Mast cells play a key role in elicitation of the early-phase and late-phase IgE-mediated allergic inflammatory reactions. Mast cells are derived from pluripotent stem cells from the bone marrow. These cells migrate through circulation into connective tissues and mucosal surfaces where they mature. On the cell surfaces, mast cells have high affinity IgE receptor(FcεRI), which react with specific IgE to...
Clinical Lecture
Neurological Examination after the Newborn Period until 3 Years of Age
Soonhak Kwon
Korean J Pediatr. 2004;47(11):1142-1148.   Published online November 15, 2004
The children should not be regarded as miniature adults since they are in the dynamic process of growth and development. Among many pediatric problems, the developmental delay may be central to them. For this reason, primary care physicians, especially pediatricians should be able to manage children with probable developmental delays because early detection and treatment of developmental delay or neurological...
Original Articles
Prevalence of Metabolic Syndrome in Obese Children
Jin Ha Chang, Duk Hee Kim, Ho-Seong Kim, In Kyoung Choi, My Young Cheong, Dong Kee Kim
Korean J Pediatr. 2004;47(11):1149-1156.   Published online November 15, 2004
Purpose : Obesity has been known to be a cause of insulin resistance and dyslipidemia, and along with coronary artery disease and diabetes, is associated with metabolic syndrome(MS). This study aimed to ascertain the cause and prevalence of MS in obese children and adolescents. Methods : Two hundred and seventy-seven school children, who showed more than a 95th percentile of body...
Review of Chromosomal Analyses Performed in a Single Hospital
Hong Kug Kim, Nam Hyang Koo, Jin Soon Hwang, Sung Hwan Kim
Korean J Pediatr. 2004;47(11):1157-1160.   Published online November 15, 2004
Purpose : Chromosomal aberration has an effect on the lives of both patients and families. Peripheral blood chromosomal analysis is useful to make a diagnosis and counsel the patient with chromosomal abnormality. We studied the cases with peripheral blood chromosomal analyses and investigated the positivity of peripheral blood chromosomal analysis. Methods : We analyzed 650 patients with chromosomal analyses in Ajou...
Clinical Features of Septic Arthritis in Neonates
Min Jung Kwak, Su Eun Park
Korean J Pediatr. 2004;47(11):1161-1166.   Published online November 15, 2004
Purpose : Septic arthritis is uncommon in neonates, and the diagnosis of septic arthritis in newborns is difficult because of non-specific laboratory findings and paucity of signs and symptoms. When appropriate treatment is delayed, permanant sequelae are inevitable. We report a retrospective study of 22 neonates who were diagnosed with septic arthritis. Methods : We reviewed 22 patients, who were diagnosed...
High Frequency Oscillatory Ventilation with Inhaled Nitric Oxide Combined Therapy in The Intractable Respiratory Failure Neonates
Mi Hyun Lee, Ji Eun Han, Sang Geel Lee
Korean J Pediatr. 2004;47(11):1167-1172.   Published online November 15, 2004
Purpose : Inhaled nitric oxide(iNO) has been known to improve oxgenation in newborns with persistent pulmonary hypertension(PPHN), but it's not clear that iNo treatment is effective in cases of acute, hypoxic respiratory failure and premature infants. In our study, high frequency oscillatory ventilation(HFV) with iNO combined therapy was tried in intractable respiratory failure neonates who showed no response to conventional...
Functional Antibody Responses to Seven Serotypes in Pneumococcal Polysaccharide Vaccine in Children
Ji Hye Park, Hee Jung Kim, Young Mi Hong, Kyung Hyo Kim
Korean J Pediatr. 2004;47(11):1173-1180.   Published online November 15, 2004
Purpose : Streptococcus pneumoniae is an important pathogen in children as well as in elderly people. The aim of this study was to assess the opsonization activity of pneumococal capsular antibody to seven serotypes in 23-valent pneumococcal polysaccharide vaccine before and after immunization in Korean children. Methods : Nine children from 24 to 49 months of age were immunized with 23-valent...
Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
Korean J Pediatr. 2004;47(11):1181-1185.   Published online November 15, 2004
Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. Results : The mean annual number of cases was 129, with a higher rate of occurrence in the...
A Clinical Study of Chronic Functional Constipation in Children Treated for more than Five Months
Young Min Kim, Sung Yun Choi, Sun Hwan Bae, Young Min Ahn
Korean J Pediatr. 2004;47(11):1186-1192.   Published online November 15, 2004
Purpose : The purpose of this study was to evaluate the clinical features and the courses and effects of long-term treatment, and to analyze the association between clinical features and duration of therapy in chronic functional constipation in children. Methods : This study enrolled 57 children with chronic functional constipation who were treated in the Eulji Hospital for more than...
Detection of Cytokeratin-19 caused by Intestinal Epithelial Cell Damage in Childhood Diarrhea
Ja Young Hwang, Se Young Seo, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Won-Bae Lee
Korean J Pediatr. 2004;47(11):1193-1197.   Published online November 15, 2004
Purpose : Acute gastroenteritis in infancy is a very common disease with a frequency of a billion diarrhea per year, leading to 3 to 5 million deaths. Since the etiology is not always clear, the treatment plan can be quite difficult to make. The laboratory examinations of stool culture, along with complete blood counts may sometimes be helpful to find...
The Incidence and Risk Factors of Posttraumatic Seizure in Children
Sue Youn, Mi A Lee, Hwang Min Kim, Byung Ho Cha
Korean J Pediatr. 2004;47(11):1198-1204.   Published online November 15, 2004
Purpose : The goal of our study was to identify the incidence and clinical, neurophysiological and neuroradiological variables with predictive value for posttraumatic seizure(PTS). Methods : The medical records of 625 children with head traumas under 15-year-old who were admitted to the Wonju Christian Hospital, from January, 1993 to January, 2002 were retrospectively reviewed. Among them, 472 patients were included...
Urine Organic Acid Analysis of Patients with Febrile Seizures
Dong Soo Shin, Gun Jun Lee, Kyeung Ja Lee, Won Il Park, Eun Joo Bae, Hong Gin Lee
Korean J Pediatr. 2004;47(11):1205-1209.   Published online November 15, 2004
Purpose : Febrile seizure, the most common seizure disorder in children between 6 months and 5 years of age, is mostly caused by viral infections, except severe CNS infection. It can also be caused by disorders in organic acid metabolism, especially accompanied by fever. Therefore we decided to investigate the relationship between children with febrile seizures and disorders in organic...
Possible Neuroprotective Role of Exogenous Growth Hormone on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Young Pyo Chang, Mi Kyung Jung, Youn Hee Jee, Jae Ju Cho, Soon Bum Lee, Woo Sung Park, Jong-Wan Kim, Dong Hoon Shin
Korean J Pediatr. 2004;47(11):1210-1215.   Published online November 15, 2004
Purpose : This study was performed to evaluate the possible neuroprotective effect of exogenous growth hormone on hypoxic-ischemic brain injury in neonatal rats. Methods : After ligation of the right common carotid artery, seven-day old Sprague-Dawley rats(n= 75) were exposed to 8% oxygen for two hours. In a growth hormone(GH)-treated group(n=25), each animal was subcutanously injected by GH(50 mg/kg, Grotrpin ,...
Case Reports
A Case of Weaver Syndrome
Jun Chul Byun, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon, Hee Jung Lee
Korean J Pediatr. 2004;47(11):1216-1219.   Published online November 15, 2004
Weaver syndrome is a very rare overgrowth syndrome with accelerated skeletal maturation, unusual facies and clinodactyly. We experienced an extremely rare case of Weaver syndrome in Korea. The clinical manifestations were macrocephaly, unusal facies, simian crease, clinodactyly, decreased muscle tone, accelerated bone age and congenital heart diseases. We report this with a brief review of related literature.
A Case of Fetal Alcohol Syndrome with Persistent Pulmonary Hypertension of the Newborn
Jin-Ha Chang, Ran Namgung, Min-Soo Park, Kook In Park, Jin-Sung Lee, Chul Lee
Korean J Pediatr. 2004;47(11):1220-1224.   Published online November 15, 2004
Fetal alcohol syndrome can be suspected in infants born to mothers with a prenatal history of alcohol abuse if the child exhibits characteristic facial features, together with intrauterine growth retardation, multiple neurological abnormalities, and multiorgan defects. If only a few of the above criteria are satisfied, the term fetal alcohol effects is used. We experienced a neonate who presented with...
A Case of Jarcho-Levin Syndrome with Intrathoracic Kidney
Shin Yun Byun, Myoung Hwa Sung, Jung Mi Choi, Tae Hong Kim, Kyu Geun Hwang, Jin A Jung
Korean J Pediatr. 2004;47(11):1225-1227.   Published online November 15, 2004
In 1938, Jarcho and Levin initially described shortening of the trunk, prominent occiput, broad forehead, multiple vertebral defects and ribs anomaly, short neck, increased anteroposterior chest diameter, lordosis, kyphoscoliosis. After that, Jarcho-Levin syndrome is an eponym that has been used to describe a variety of clinical phenotypes. We examined a girl who was suspected as suffering from Jarcho-Levin syndrome because...
A Case of Spinal Cord Injury without Radiographic Abnormality
Seoung Joon Kim, Dae Kyun Koh, Jin Hee Oh, Jong Hyun Kim, Jung Soo Jun
Korean J Pediatr. 2004;47(11):1228-1231.   Published online November 15, 2004
A spinal cord injury without radiographic abnormality(SCIWORA) was defined by Pang and Wilberger in 1982 as the "objective signs of myelopathy as a result of trauma" in which no evidence of fracture, subluxation, or instability on plain radiographs, or computed tomography is demonstrable. Inherent elasticity of the vertebral column in infants and young children, among other age-related anatomical peculiarities, render...