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Volume 49(7); Jul 2006
Review Articles
Current use of growth hormone in children
Choong Ho Shin
Korean J Pediatr. 2006;49(7):703-709.   Published online July 15, 2006
Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final...
Type 2 diabetes mellitus and metabolic syndrome
Jin Soon Hwang
Korean J Pediatr. 2006;49(7):710-717.   Published online July 15, 2006
Type 2 diabetes mellitus in children and adolescents has been increasing for last 10 years. The increase in frequency of type 2 diabetes appears to parallel the increase in prevalence and severity of obesity in children and adolescents. The metabolic syndrome, cluster of potent risk factors for atherosclerotic cardiovascular disease and type 2 diabetes, consists of insulin resistance, obesity, hypertension...
Update in the etiology and treatment of sexual precocity
Mi Jung Park
Korean J Pediatr. 2006;49(7):718-725.   Published online July 15, 2006
The pubertal activation of gonadotrophin releasing hormone(GnRH) requires coordinated changes in excitatory or inhibitory amino acids, growth factors, and a group of transcriptional regulators. The age of onset of puberty is progressing to younger age. Factors affecting early puberty include genetic traits, nutrition(body fat) and exposure to endocrine disrupting chemicals. In rapidly progressing central precocious puberty, gonadotrophin releasing hormone(GnRH) agonists(GnRHa)...
Original Articles
The efficacy of optimal doses of intramuscular ketamine and midazolam injections for procedural sedation in laceration repair of children
Je Sung You, Young Soon Cho, Young Hwan Choi, Seung Hwan Kim, Hahn Shick Lee, Jin Hee Lee
Korean J Pediatr. 2006;49(7):726-731.   Published online July 15, 2006
Purpose : We reported previously that intramuscular ketamine with adjunctive midazolam is more effective than ketamine alone in pediatric procedural sedation, but with limited satisfactory sedation by suboptimal ketamine dose. The optimal dose of intramuscular ketamine in children has never been studied in Korea. In this study, we investigated the effectiveness and adverse events of ketamine 4mg/kg with adjunctive midazolam...
Evaluation of diagnostic methods in children with nonpalpable undescended testis
Noh Sung Seok, Hong Jin Suh, Dong Hwan Lee
Korean J Pediatr. 2006;49(7):732-736.   Published online July 15, 2006
Purpose : Numerous methods exist for diagnosing nonpalpable testis in treatment of cryptochidism. However, there is no clinically established data for the rational diagnostic tool of nonpalpable testis in terms of expenses. We tried to establish a current conventional diagnostic course of nonpalpable testis. We then evaluated the efficacy of ultrasonography, physical examination under general anesthesia and laparoscopy for diagnosing...
Diagnostic limitation and usefulness of 99mTc-DISIDA hepatobiliary scanning on neonatal cholestasis
Jung Mi Kim, Byung-Ho Choi, You Cheol Jang, Ki Won Oh, Min Hyun Cho, Kyung Hee Lee, Jin-Young Park, Heng Mi Kim
Korean J Pediatr. 2006;49(7):737-744.   Published online July 15, 2006
Purpose : To assess the usefulness of 99mTc-DISIDA scanning in the early evaluation of neonatal cholestasis and to verify the diagnostic value of this test in the differential diagnosis of biliary atresia. Methods : DISIDA scannings were performed and analyzed in 87 children(58 males and 29 females; age, 18-139 days, mean, 59.1 days) with neonatal cholestasis. Five groups according to the...
Utility of polymerase chain reaction(PCR) according to sampling time in CSF and stool specimens from patient with aseptic meningitis
Myo Jing Kim, Hye Jin Lee, Jung Mi Choi, Soo Jin Jung, Jae Won Huh
Korean J Pediatr. 2006;49(7):745-750.   Published online July 15, 2006
Purpose : Enteroviruses are the most common cause of aseptic meningitis in patients of all ages. A definite diagnosis of enteroviral meningitis can be established by detection of virus directly in CSF specimens. But this is time-consuming and lacks sensitivity, so polymerase chain reaction(PCR) detecting of viral RNA in patient specimens such as CSF, stool has been demonstrated. But little...
A study for headaches and backaches occurrence after diagnostic lumbar puncture in children
In Young Choi, Kyong Yun Park, Young Taek Jang
Korean J Pediatr. 2006;49(7):751-756.   Published online July 15, 2006
Purpose : Our goals were to determine the frequency of headaches and backaches occurring as a side effect following lumbar puncture in children, and to investigate various factors that might influence the frequency of headaches and backaches. Methods : From October 2004 to February 2006, we enrolled 148 patients aged 2 to 15 years who received diagnostic lumbar puncture at the...
Database study for clinical guidelines of children with pneumonia who visited an emergency department
Dae Young Hong, Kyung Mi Lee, Ji Hye Kim, Jun Sig Kim, Seung Baik Han, Dae-Hyun Lim, Byoung Kwan Son, Hun Jae Lee, Kyung-Hee Lee
Korean J Pediatr. 2006;49(7):757-762.   Published online July 15, 2006
Purpose : Pneumonia is one of the most common infections in children who visit emergency departments(ED), but standard clinical guidelines for children with pneumonia in Korea have not been studied. This study was performed to collect and evaluate a data-base of children with pneumonia for establishing clinical guidelines in ED. Methods : This study reviewed 304 children who were diagnosed...
The evaluation of risk for aspiration using lipid-laden macrophage index in infants with bronchiolitis
Ji Yeon Koh, Hee Kang, Ju Young Chung, Tae Hee Han, Chang Keun Kim
Korean J Pediatr. 2006;49(7):763-768.   Published online July 15, 2006
Purpose : We investigated the risk of aspiration using the lipid-laden macrophage index(LLMI) from laryngeal lavages in infants with bronchiolitis. Methods : Laryngeal lavages from 22 infants with acute bronchiolitis caused by respiratory syncytial virus(RSV) were evaluated during the acute stage. Repeat studies were performed at 3 to 4 weeks after the initial study(remission stage). Lavage cell counts and differentials were...
Pulse wave velocity and ankle brachial index in adolescents with essential hypertension
Sun Young Joo, Ki Young Cho, Su Jin Cho, Young Mi Hong
Korean J Pediatr. 2006;49(7):769-776.   Published online July 15, 2006
Purpose : Pulse wave velocity(PWV) and ankle brachial index(ABI) are not only noninvasive methods used to assess arterial stiffness in adults, but also useful, simple ways to estimate the severity of hypertension, end stage renal disease and atherosclerosis in adults. But there are few studies on PWV and ABI in adolescents and children. In this study, hypertensive adolescents were compared...
Susceptibility tests of oral antibiotics including cefixime against Escherichia coli, isolated from pediatric patients withcommunity acquired urinary tract infections
Soo Young Lee, Jung Hyun Lee, Jong Hyun Kim, Jae Kyun Hur, Sun Mi Kim, Sang Hyuk Ma, Jin Han Kang
Korean J Pediatr. 2006;49(7):777-783.   Published online July 15, 2006
Purpose : Urinary tract infection(UTI) is one of the most frequent infections in children. E. coli is the most frequent etiological micropathogen in pediatric community UTI, and E. coli has developed resistance to many antibiotics, highlighting the need for regular surveys of this organism resistant patterns in the community. The aim of this study was to determine the oral antibiotic...
Intravenous immunoglobulin for severe gastrointestinal manifestation of Henoch-Sch nlein purpura refractory to corticosteroid therapy
Hye Ran Yang, Won Jung Choi, Jae Sung Ko, Jeong Kee Seo
Korean J Pediatr. 2006;49(7):784-789.   Published online July 15, 2006
Purpose : Henoch-Schönlein purpura(HSP) is a systemic vasculitis involving small vessels of skin, gastrointestinal(GI) tract and kidney. Digestive involvement of HSP can be serious with massive GI bleeding, perforation, and intussusception. However, some patients do not respond to conventional corticosteroid therapy. In this study, we investigated the efficacy of intravenous immunoglobulin (IVIG) for serious digestive manifestations not responding to steroid. Methods...
Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
Korean J Pediatr. 2006;49(7):790-795.   Published online July 15, 2006
Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD). Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to...
Case Reports
A case of multicystic dysplastic kidney and cystic adenomatoid malformation of the lung identified as incidental findings
Sun-Joo Lee, Ji-Hun Lee, Hyun-Hee Kim, So-Young Kim, Seung-Hoon Hahn, Ja-Young Hwang, Wonbae Lee
Korean J Pediatr. 2006;49(7):796-799.   Published online July 15, 2006
Multicystic dysplastic kidney and congenital cystic adenomatoid malformation of the lung are independent disorders, but both result from abnormal morphogenesis during embryogenesis. Congenital cystic adenomatoid malformation of the lung is associated with renal anomalies as well as other extrapulmonary anomalies and almost all cases with these anomalies are stillborn. We report a case of a 21-month-old male who was...
Primary peritoneal drainage as a treatment for perforated necrotizing enterocolitis with bacterial peritonitis in an extremely low birth weight infant : a case report
Wook Sun Choi, Il Hong Moon, Jang Hoon Lee, Seung Hwa Lee, Byung Min Choi, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
Korean J Pediatr. 2006;49(7):800-804.   Published online July 15, 2006
Necrotizing enterocolitis(NEC) is the most common life-threatening surgical emergency in neonates, and remains a major cause of morbidity and mortality. In addition to conventional laparotomy, intraperitoneal drains have been used for the treatment of perforated NEC, especially in extremely low birth weight(ELBW) infants. We report a case of perforated NEC with bacterial peritonitis in an ELBW infant managed with primary...
Pulmonary carcinoid tumor presented with recurrent pneumonia in adolescence
Eun Sil Park, Ji Suk Park, Jae Young Lim, Joung Hee Lee, Gyung Hyuck Ko
Korean J Pediatr. 2006;49(7):805-809.   Published online July 15, 2006
The incidence of endobronchial tumor in the pediatric period is very rare and the symptoms are very close to those of respiratory tract infection. Diagnosis can be delayed because of low clinical suspicion and the many ways in which these tumors can present. We report the first case, in Korea, of a pulmonary carcinoid tumor that presented with recurrent pneumonia...