- Perspective
- Infection
- COVID-19 in children: reasons for uneventful clinical course
- Sweni Shah, Ramachandran Meenakshisundaram, Subramanian Senthilkumaran, Ponniah Thirumalaikolundusubramanian
- Clin Exp Pediatr. 2020;63(7):237-238. Published online June 18, 2020
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- Review Articles
- Immunology
- Immunopathogenesis of COVID-19 and early immunomodulators
- Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
- Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020
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The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ...
- Pulmonology
- The past, present, and future of humidifier disinfectant-associated interstitial lung diseases in children
- Eun Lee, So-Yeon Lee, Soo-Jong Hong
- Clin Exp Pediatr. 2020;63(7):251-258. Published online December 9, 2019
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Exposure to environmental factors can cause interstitial lung diseases (ILDs); however, such types of ILDs are rare. From 2007 to 2011, an ILD epidemic occurred in South Korea owing to inhalational exposure to toxic chemicals in humidifier disinfectants (HDs). HD-associated ILDs (HD-ILDs) are characterized by rapidly progressing respiratory failure with pulmonary fibrosis and a high mortality rate of 43.8%−58.0%. Although...
- Editorials
- Infection
- Pneumococcal conjugate vaccines: choice of schedule and product development
- Jin Lee
- Clin Exp Pediatr. 2020;63(7):259-260. Published online April 27, 2020
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- Gastroenterology
- Management of perianal abscess and fistula-in-ano in infants and children
- Jinyoung Park
- Clin Exp Pediatr. 2020;63(7):261-262. Published online March 23, 2020
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- Allergy
- Trends in prevalence of allergic diseases in Korean children: how and why?
- Kyung Suk Lee
- Clin Exp Pediatr. 2020;63(7):263-264. Published online April 13, 2020
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- Original Articles
- Immunology
- Immunogenicity and safety of a 12-valent pneumococcal conjugate vaccine in infants aged 6–10 weeks: a randomized double-blind active-controlled trial
- Jonghoon Shin, Jamaree Teeratakulpisarn, Thanyawee Puthanakit, Tuangtip Theerawit, Ji Hwa Ryu, Jinhwan Shin, Seulgi Lee, Hayoung Lee, Kyungjun An, Hun Kim
- Clin Exp Pediatr. 2020;63(7):265-271. Published online December 6, 2019
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Question: The immunogenicity and safety of GBP411 when administered to healthy infants are not understood.
Finding: The intergroup differences were not significant for all 12 serotypes after the booster dose. The overall incidence of solicited local adverse events between the groups did not differ significantly.
Meaning: GBP411 with a 2p+1 dosing schedule induced a substantial immune response, and may be safe for administration to healthy infants.
- General Pediatrics
- Efficacy of conservative treatment of perianal abscesses in children and predictors for therapeutic failure
- Lars Boenicke, Johannes Doerner, Stefan Wirth, Hubert Zirngibl, Mike Ralf Langenbach
- Clin Exp Pediatr. 2020;63(7):272-277. Published online May 15, 2020
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Background: The optimal management of perianal abscess in children is controversial.
Purpose: To evaluate the efficiency of conservative treatment of perianal abscess in children and identify parameters that predict therapy failure. Methods: All cases of children younger than 14 years of age with perianal abscesses between 2001–2016 were evaluated. Results: Of the 113 enrolled patients, 64 underwent subsequent surgery for advanced disease (primary...
- Allergy
- Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017
- Jihyun Ha, Seung Won Lee, Dong Keon Yon
- Clin Exp Pediatr. 2020;63(7):278-283. Published online January 29, 2020
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Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.
Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017. Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the...
