Most cited
- Page Path
-
- HOME
- BROWSE ARTICLES
- Most cited
Most-cited articles are from the articles published during the last two years (2024 ~ ).
- Original Article
- General Pediatrics
- Global and regional burden of neonatal disorders (preterm birth, encephalopathy, jaundice, and sepsis), 1990–2021 and projections to 2050
-
Yuseon Kang, Jeongseon Oh, Dongjin Yeo, Jaeyu Park, Sooji Lee, Na Yun Kim, Jungmin Park, Seung Ha Hwang, Tae Hyeong Kim, Dong Keon Yon
-
Clin Exp Pediatr. 2026;69(2):171-181. Published online October 30, 2025
-
|
This study provides the first comprehensive estimated global burden of neonatal disorders attributable to risk factors in 1990–2021 stratified by sex, cause, sociodemographic index (SDI), and region. We identified persistent disparities across SDI levels, with low birthweight and short gestation contributing most to the age-standardized disability-adjusted life year rate of neonatal disorders. These findings highlight the urgent need for targeted context-specific interventions to reduce infant mortality and improve neonatal health equity. |
-
-
- Gastroenterology
- Progression from acute to chronic pancreatitis in children: a systematic review and meta-analysis
-
Endre Botond Gagyi, Mahmoud Obeidat, Edina Tari, Szilárd Váncsa, Dániel Sándor Veres, Peter Banovcin, Péter Jenő Hegyi, Péter Hegyi, Bálint Erőss
-
Clin Exp Pediatr. 2026;69(2):117-129. Published online December 4, 2025
-
|
Approximately 1 in 5 children with acute pancreatitis develops recurrent attacks, and over one-third of such cases progress to chronic pancreatitis. Progression is closely linked to genetic mutations, particularly PRSS1, and anatomical abnormalities, whereas demographic and routine clinical factors lack predictive value. These results support early genetic and anatomical assessments, enabling targeted follow-ups and timely interventions in highrisk pediatric patients. |
-
-
- Original Article
- Neonatology (Perinatology)
- Respiratory severity score-guided postnatal systemic corticosteroid therapy for bronchopulmonary dysplasia in extremely preterm infants
-
Gyeong Eun Yeom, Ju Sun Heo, Baek Sup Shin, Seh Hyun Kim, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim
-
Clin Exp Pediatr. 2025;68(9):656-665. Published online July 8, 2025
-
|
Question: Does a respiratory severity score (RSS)-guided postnatal corticosteroid protocol improve respiratory outcomes of extremely preterm (EP) infants without worsening neurodevelopmental outcomes?
Finding: The protocol enabled targeted and early steroid use, thereby reducing severe bronchopulmonary dysplasia without affecting mortality or causing neurodevelopmental impairments.
Meaning: The RSS-guided protocol may offer a more precise and individualized postnatal corticosteroid therapy for EP infants. |
-
-
- Neurology
- Establishing an induced pluripotent stem cell bank using urine cells from pediatric patients with neurogenetic diseases
-
Hien Bao Dieu Thai, WonWoo Jung, Sol Choi, Woo Joong Kim, JangSup Moon, ByungChan Lim
-
Clin Exp Pediatr. 2025;68(8):569-577. Published online April 1, 2025
-
|
Question: What can be used to create a reliable supply of somatic cells for induced pluripotent stem cells (iPSCs) generation and standardize procedures for building an iPSC bank for researching pediatric neurogenetic disorders?
Findings: Noninvasively acquired urine cells are a desirable cell source for iPSC reprogramming.
Meaning: An iPSC bank can be created from diverse patient cell sources and offer a useful resource for translating research results into clinical therapy for pediatric neurogenetic disorders. |
-
-
- Clinical Note
- Genetics and Metabolism
- Expanding genotype-phenotype correlation of Kenny-Caffey syndrome type 1
-
Manuela Lo Bianco, Federica Sipala, Xena Giada Pappalardo, Gaia Fusto, Roberta Rizzo, Federico Favata, Carla Cimino, Silvia Marino, Martino Ruggieri, Agnese Suppiej, Simone Ronsisvalle, Raffaele Falsaperla
-
Clin Exp Pediatr. 2025;68(8):616-619. Published online May 12, 2025
-
-
-
- Original Article
- Neonatology (Perinatology)
- Evaluation of total serum bilirubin thresholds for discontinuing phototherapy in jaundiced neonates: a randomized study
-
Ajay Kumar, Nidhi Jain
-
Clin Exp Pediatr. 2025;68(7):539-545. Published online February 26, 2025
-
|
Question: What are the outcomes of jaundiced neonates when phototherapy is discontinued at 2 different total serum bilirubin (TSB) thresholds?
Findings: The study involved 80 neonates, comparing a recommended TSB threshold and a lower threshold for phototherapy discontinuation. Results showed a 14.3% reinstitution rate of treatment, with no adverse outcomes.
Meaning: Careful posttreatment monitoring is essential when discontinuing phototherapy, and future research should consider updated guidelines like those from the American Academy of Pediatrics. |
-
-
- Original Article
- Oncology
- Prognostic role of mid-regional pro-adrenomedullin in predicting infection in pediatric cancer with febrile neutropenia
-
Seham M. Ragab, Sara Mahmoud El-Deeb, Ahmed Saeed, Asmaa A. Mahmoud
-
Clin Exp Pediatr. 2025;68(6):445-453. Published online January 13, 2025
-
|
· Infection remains a leading cause of death in febrile neutropenia (FN).
· Mid-regional pro-adrenomedullin (MR-ProADM) levels are higher among patients with FN and a bacterial infection.
· A longer FN duration and hospital stay length as well as elevated C-reactive protein, procalcitonin, and MR-ProADM levels are significant risk factors for mortality. |
-
-
- Review Article
- Critical Care Medicine
- Protocolized sedation may reduce ventilation and sedation requirements in the pediatric intensive care unit: a systematic review and meta-analysis
-
Ambrus Szemere, Alíz Fazekas, Anna Réka Sebestyén, Rani Ezzeddine, Veronika Upor, Marie Anne Engh, Péter Hegyi, Zsolt Molnár, Klára Horváth
-
Clin Exp Pediatr. 2025;68(6):406-416. Published online February 19, 2025
-
|
|
Protocolized sedation may reduce ventilation requirements, pediatric intensive care unit length of stay, and sedative exposure. However, it may increase the likelihood of unplanned extubation, highlighting the importance of incorporating preventive measures to mitigate this risk. |
-
-
- Editorial
- Other
- Further research on impact of microplastics on children's health is essential to protecting future generations
-
Jongin Lee, Dong-Wook Lee
-
Clin Exp Pediatr. 2025;68(5):359-361. Published online November 13, 2024
-
|
|
· The ecological impacts of microplastics have been documented. It was recently recognized that they can directly or indirectly cause diseases in humans.
· There are few established methods for assessing human exposure to microplastics.
· Standardization of exposure assessments and large-scale epidemiological studies are required to explore the human effects of microplastics. |
-
-
- General Pediatrics
- The role of serum zinc and selenium levels in etiology of febrile seizures
-
Yavuz Ataş, Hatice Gamze Poyrazoğlu
-
Clin Exp Pediatr. 2025;68(5):388-394. Published online January 13, 2025
-
|
Zinc may play a key role in preventing febrile seizures by increasing the seizure threshold and reducing oxidative stress. Incorporating zinc supplements into treatment could help protect children from the adverse effects of febrile seizures and improve their overall outcomes. |
-
-
- Nutrition
- Differential effects of dietary and physical activity interventions on adiposity of children with obesity
-
Anekchoke Tangtongsoong, Chonnikant Visuthranukul, Yuda Chongpison, Sirinuch Chomtho
-
Clin Exp Pediatr. 2025;68(5):370-378. Published online February 3, 2025
-
|
Question: How do dietary intake and physical activity affect body mass index (BMI) z scores and adiposity among children with obesity?
Finding: Higher dietary protein and fiber intakes were significantly associated with a decrease in BMI z scores and adiposity among children with obesity.
Meaning: Optimizing dietary interventions by focusing on protein and fiber intakes could be an effective strategy for managing childhood obesity. |
-
-
- Review Article
- Neurology
- Cerebral organoid research for pediatric patients with neurological disorders
-
Jin Eun, Jung Eun Lee, Seung Ho Yang
-
Clin Exp Pediatr. 2025;68(4):269-277. Published online November 28, 2024
-
|
Cerebral organoids obtained from human induced pluripotent stem cells are transforming the study of pediatric neurological diseases by providing more accurate models of human brain development and pathology. These advancements have improved pathology modeling and the potential for novel therapeutic approaches despite existing challenges such as reproducibility and vascularization. |
-
-
- Original Article
- Nephrology (Genitourinary)
- C3 glomerulopathy in children: experience at a resource-limited center
-
Soumya Reddy, Abhishek Ghante, Mahesha Vankalakunti, Anil Vasudevan
-
Clin Exp Pediatr. 2025;68(4):311-318. Published online November 28, 2024
-
|
Question: What are the clinicopathological features and outcomes of pediatric C3 glomerulopathy (C3G) in resource-limited settings?
Finding: Children with C3G in resource-limited settings have significant morbidities, and most experience kidney sequelae despite treatment. Electron microscopy was performed in only 50% of our patients, while none received complement assays or genetic testing.
Meaning: Pediatric C3G presentation, management, and kidney outcomes vary. Its thorough evaluation and management are challenging in resource-limited settings. |
-
-
- Editorial
- Nutrition
- Zinc as a treatment modality for acute infectious diarrhea in children
-
Ji Sook Park
-
Clin Exp Pediatr. 2025;68(3):223-224. Published online October 31, 2024
-
|
|
· Prevention and management of dehydration is the major goal of treatment in acute infectious diarrhea in children.
· Zinc could be effective as an adjuvant therapy in reducing the duration of acute infectious diarrhea in malnourished children. |
-
-
- Original Article
- Genetics and Metabolism
- Long-term follow-up of neurocognitive function in patients with citrin deficiency and cholestasis
-
Meng-Ju Melody Tsai, Jung-Chi Chang, Heng-Yu Lu, Susan Shur-Fen Gau, Yin-Hsiu Chien, Wuh-Liang Hwu, Yen-Hsuan Ni, Huey-Ling Chen, Ni-Chung Lee
-
Clin Exp Pediatr. 2025;68(3):257-265. Published online November 28, 2024
-
|
Question: Do transient metabolic disturbances in early childhood due to citrin deficiency have lasting effects on neurocognitive function?
Finding: Children with citrin deficiency have a higher prevalence of ADHD compared to the general population, with elevated ammonia levels in infancy associated with increased hyperactivity-impulsivity risk.
Meaning: Metabolic disturbances in early childhood due to citrin deficiency may contribute to long-term neurocognitive impacts, particularly ADHD, while IQ and life outcomes generally remain normal. |
-
-
- Original Article
- Infection
- Clinical characteristics and associated factors of pediatric acute necrotizing encephalopathy: a retrospective study
-
Huiling Zhang, Yilong Wang, Qianyun Ding, Xuekun Li, Sheng Ye
-
Clin Exp Pediatr. 2025;68(2):153-162. Published online November 11, 2024
-
|
· The mortality rate of acute necrotizing encephalopathy was high.
· Laboratory tests revealed that the fatal group had higher creatinine, lactate, activated partial thromboplastin time, thrombin time, interleukin (IL)-6, IL-10, creatine kinase, and D-dimer than survivors.
· The fatal group displayed lower Glasgow Coma Scale scores and arterial pH. |
-
-
- Editorial
- Allergy
- Effect of metabolic syndrome on pulmonary dysfunction in children with asthma
-
Hyo-Bin Kim
-
Clin Exp Pediatr. 2025;68(2):136-137. Published online November 13, 2024
-
|
|
· The prevalence of metabolic syndrome increased in Korean children during the coronavirus disease 2019 pandemic owing to reduced physical activity resulting from social distancing.
· Metabolic syndrome impacts pulmonary dysfunction in childhood asthma.
· Further studies are needed to understand the mechanism linking asthma and metabolic syndrome and develop interventions. |
-
-
- Review Article
- Hematology
- Promising role of voxelotor in managing sickle cell disease in children: a narrative review
-
Amit Agrawal, Gaurav Jadon, Japna Singh, Dalwinder Janjua
-
Clin Exp Pediatr. 2025;68(2):106-114. Published online November 13, 2024
-
|
Voxelotor has promising ability to increase hemoglobin levels and reduce hemolysis markers in patients with sickle cell disease (SCD). Several preclinical and phase II/III trials have demonstrated its efficacy, dose-dependent responses, and tolerability in children. Ongoing trials are assessing its safety and effectiveness in various populations, including children younger than 12 years. These findings suggest its potential as a disease-modifying drug, warranting further exploration of its role in SCD management. |
-
-
- Original Article
- Neonatology (Perinatology)
- Effect of high-frequency oscillatory ventilation with intermittent sigh breaths on carbon dioxide levels in neonates
-
Kulthida Baingam, Anucha Thatrimontrichai, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate
-
Clin Exp Pediatr. 2025;68(2):178-184. Published online November 13, 2024
-
|
Question: Can sigh breaths (Sighs) application during high-frequency oscillatory ventilation (HFOV) decrease partial pressure of carbon dioxide (PaCO2) levels?
Finding: The mean PaCO2 level after Sighs during HFOV was significantly decreased compared to that after HFOV alone (mean difference, -3.6 mmHg).
Meaning: HFOV plus Sighs functionality can reduce PaCO2 levels. However, further studies are required to conclusively determine the effects of Sighs. |
-
-
- Gastroenterology
- Differences in immune cells and gene expression in human milk by parity on integrated scRNA sequencing
-
Dae Yong Yi, Hong-Jai Park, Min Sun Shin, Hyoungsu Kim, Sang Jin Lee, Insoo Kang
-
Clin Exp Pediatr. 2025;68(2):141-152. Published online January 10, 2025
-
|
Question: Is there a difference in immune cells in human breast milk by parity?
Finding: There were higher proportions of monocytes and T/B cells in the primiparous and multiparous group, respectively. The expression of genes with a direct role in the infant immune system and immune response-related genes were highest in the primiparous group
Meaning: There were parity-dependent differences in the expression of genes between innate and adaptive immune cells. |
-
-
- Hematology
- Assessment of natural killer cell subpopulations in pediatric patients with transfusion-dependent β-thalassemia major
-
Fathia Ibrahim Elbassal, Mohamed Abdel Rehim Soliman, Nourhan Hossam Eldin Mohamed, Mai El-Sayad Abd El-Hamid, Hanan Hassan El-Sheity
-
Clin Exp Pediatr. 2025;68(12):981-990. Published online September 12, 2025
-
|
Question: How does iron overload affect immunity in pediatric patients with transfusion-dependent β-thalassemia major?
Finding: Iron overload in these patients is associated with disrupted natural killer (NK) cell subpopulations, reflecting impaired innate immunity.
Meaning: This highlights the need to monitor immune profile alongside iron status during thalassemia management. |
-
-
- Oncology
- HLA‒B*58:01 and skin reactions in pediatric hematology and oncology patients treated with allopurinol
-
Parisa Maneechai, Cholada Ratanatharathron, Jassada Buaboonam, Kleebsabai Sanpakit
-
Clin Exp Pediatr. 2025;68(12):974-980. Published online October 2, 2025
-
|
Question: Does human leukocyte antigen (HLA)–B*58:01 increase the risk of cutaneous reactions in pediatric patients with hematological and oncological diseases receiving allopurinol?
Finding: : Of 108 patients, 17.6% carried HLA–B*58:01 but none developed skin reactions. The only rash occurred in an HLA-B*58:01–negative patient.
Meaning: Short-duration allopurinol may mitigate severe cutaneous adverse reaction risk regardless of genotype. Routine HLA-B*58:01 screening may be unnecessary in pediatric patients with hematological and oncological diseases briefly receiving allopurinol. |
-
-
- Infection
- Serum copper and ceruloplasmin levels as biomarkers reflecting liver fibrosis in children with autoimmune hepatitis
-
Salma Abdel Megeed Nagi, Mai Ibrahim Elashmawy, Amany E. Elashkar, Mohamed Zaeim Hafez, Ashraf A.E. Emara, Osama Mohammad Abdelhay, Albayoumi A.B. Fouda, Mohamed AbdelAziz Doma, Ahmad Mohamed Awad, Ahmed Mohammed Saba, Hesham Abdelrahman Ahmed, Ahmed Mohamed Gad Allah, Fatma Mahmoud Abdelraheem, Mohamed A. Gad, Mohamad A. Soliman, Tamer I. Abdalrhman, Khaled Hassaan Awad, Ismael A.K.M. El-lebedy, Mostafa M. Abdelnaser, Mohammed Z. Abdel Kareem, Marwa Fekry Hassan, Shymaa Sobhy Menshawy Khalifa
-
Clin Exp Pediatr. 2025;68(11):909-920. Published online August 6, 2025
-
|
· A total of 159 children with autoimmune hepatitis (AIH; 60.3% female, 13.2% type 2 AIH) were identified. According to a global study, the estimated annual incidence of AIH in Egypt is 1.28 cases per 100,000 inhabitant-years.
· No studies to date have examined the serum levels of copper or ceruloplasmin in children with AIH. Therefore, here we investigated whether serum copper and ceruloplasmin levels are useful for identifying liver fibrosis in children with AIH.
· Serum copper and ceruloplasmin levels may provide important information for the identification of advanced liver fibrosis in children with AIH. |
-
-
