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Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum
calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase
activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective
disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to
calcitriol and increased catabolism of calcitriol.
In children with renal hypophosphatemic rickets, growth... |