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Case Report
Oncology
Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome
Do Hee Ahn, Jung Hee Rho, Hann Tchah, In-Sang Jeon
Clin Exp Pediatr. 2016;59(1):40-42.   Published online January 22, 2016

Lynch syndrome is the most common inherited colon cancer syndrome. Patients with Lynch syndrome develop a range of cancers including colorectal cancer (CRC) and carry a mutation on one of the mismatched repair (MMR) genes. Although CRC usually occurs after the fourth decade in patients with Lynch syndrome harboring a heterozygous MMR gene mutation, it can occur in children with...

Original Article
Vascular endothelial dysfunction after anthracyclines treatment in children with acute lymphoblastic leukemia
Woo Jung Jang, Duk Yong Choi, In-Sang Jeon
Clin Exp Pediatr. 2013;56(3):130-134.   Published online March 18, 2013
Purpose

Anthracyclines have been utilized in the treatment of children with acute lymphoblastic leukemia (ALL). Recent studies have shown that anthracyclines may induce toxicity in the vascular endothelium. This study was performed using brachial artery reactivity (BAR) to evaluate vascular endothelial function in ALL patients who were treated with anthracycline chemotherapy.

Methods

We included 21 children with ALL who received anthracycline chemotherapy and...

Predictive indicators of coronary artery complications in Kawasaki disease
Min Jee Park, In-sang Jeon, Hann Tchah, Kang Ho Cho, Mi-Jin Jung, Deok Young Choi
Clin Exp Pediatr. 2009;52(10):1161-1166.   Published online October 15, 2009
Purpose : Kawasaki disease—the most common cause of acquired heart disease in children—incidence is increasing yearly. Therefore, we evaluated the predictive indicators of coronary complications of Kawasaki disease based on clinical and laboratory data. Methods : Between January 2005 and March 2008, of the 201 children with Kawasaki disease treated at the Gil Hospital of Gachon University of Medicine and...
Platelet count change by vincristine in maintenance phase of acute lymphoblastic leukemia chemotherapy
Sung Moon Lee, Soon Shik Ham, In-sang Jeon
Clin Exp Pediatr. 2006;49(2):181-186.   Published online February 15, 2006
Purpose : The hematologic change during the treatment of acute lymphoblastic leukemia(ALL) is critical as a prognostic determinant and a variable to determine the dose of chemotherapeutic agents. It is known that the dose of vincristine used in the maintenance phase of ALL is small enough to increase the count of platelet. To investigate the change of platelet count according...
Case Report
Prevention and Dissociation of the Platelet Aggregation in a Patient with EDTA-dependent Pseudothrombocytopenia by Supplementation of Kanamycin : A Case Report
In-sang Jeon, Sung Wan Yang
Clin Exp Pediatr. 2005;48(6):675-677.   Published online June 15, 2005
Pseudothrombocytopenia is usually associated with anticoagulant ethylene diaminetetraacetic acid (EDTA). The platelet clumping that occurs in EDTA-dependent pseudothrombocytopenia (EDPT) can sometimes be prevented by the use of other anticoagulants such as heparin or sodium citrate. As an alternative, we used kanamycin before or after the withdrawal of EDTA-anticoagulated blood in a 6-year-old boy with EDPT. Kanamycin used supplementarily during the...
Neurofibromatosis Type 1 with Cerebellar Piloytic Astrocytoma
In-Sang Jeon, Jung Sun Kim, Ji Hye Kim, Na Rae Kim
Clin Exp Pediatr. 2004;47(4):458-461.   Published online April 15, 2004
Neurofibromatosis type 1(NF1) is one of the most common inherited disorders, clinically characterized by caf -au-lait spots, Lisch nodules and neurofibromas. In addition, the affected individuals usually develop benign and malignant tumors of the nervous system. One of the most common tumors is the optic nerve glioma. NF1-associated glioma, however, rarely occurs in the cerebellum. Recently, we experienced a NF1-associated...
A Case of Nasal T/NK-cell Lymphoma
Jung Bok Lee, In-sang Jeon, Ho Joon Im, Young Ha Oh, Ji Hye Kim
Clin Exp Pediatr. 2003;46(12):1266-1270.   Published online December 15, 2003
The advance of the immunobiology clarifies the nature of non-Hodgkin's lymphoma(NHL). In addition the proceed in the immunophenotyping renders the classification of NHL. According to the Revised European American Lymphoma(REAL) classification, classified by the etiologic factors, molecular biological characteristics, immunophenotype, cytogenetics and histologic feature, nasal T/NK-cell lymphoma(=angiocentric lymphoma) belongs to the category of peripheral T-cell and natural killer cell lymphoma....
Original Article
1-β-D-Arabinofuranosyl-cytosine Induces Chromosomal Breaks in vitro
In-sang Jeon
Clin Exp Pediatr. 2003;46(12):1186-1193.   Published online December 15, 2003
Purpose : Fragile sites are points on chromosomes which tend to break non-randomly when exposed to specific chemical agents or conditions of tissue culture. The chromosomal break induced by the antineoplastic drug, 1-β-D-arabinofuranosyl-cytosine(Ara-c), was investigated to study the laboratory conditions in which the incidence of chromosomal break could be enhanced. Besides, the fragile sites induced by Ara-C were investigated...
Molecular Cloning and Characterization of ETV1 : a New Member of the ETS Family Transcription Factor that is Implicated in Ewing's sarcoma
In-sang Jeon, David N. Shapiro
Clin Exp Pediatr. 1999;42(6):833-843.   Published online June 15, 1999
Purpose : Ewing's sarcoma is characterized by accompanying specific chromosome translocations. In the present study, we report ETV1, the third member of the human ETS family that is implicated in Ewing's sarcoma by reciprocal translocation (7;22)(p22;q12). Methods : Primarily, cDNA library made from the Ewing's sarcoma cell line accompanying the t(7;22)(p22;q12) was screened using the 5' portion of EWS(including the...
The Impact of Prolonged Breast Milk Feeding and Large Amount of Whole Cow's Milk Intake on Iron Status in Early Childhood
Pei Tai Wang, In-sang Jeon
Clin Exp Pediatr. 1998;41(4):437-443.   Published online April 15, 1998
Purpose : The Large amounts of whole cow’s milk intake, just followed by prolonged breast milk feeding may induce a severe deficit of iron. We performed this study to investigate the severity of iron deficiency in these subjects. Methods : Seventy-one subjects(12 to 48 months of age) were classified according to history of prolonged breast milk feeding and intake of large amounts of whole...