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Original Article

Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes

Eun Hwa Choi, Hee Sup Kim, Stephen J. Chanock, Hoan Jong Lee

Clin Exp Pediatr. 2005;48(5):495-499. Published online May 15, 2005

Purpose : Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in Korean children with a common haplotype of the IL4 promoter. This study was performed to investigate functional differences of the variant IL4 promoter haplotypes. Methods : Genomic DNA was obtained...

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