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Original Article

Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma

Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Won-Ah Choi, Young-Jun Kim, Mi-Jin Kang, Jinho Yu, Soo-Jong Hong

Clin Exp Pediatr. 2011;54(9):373-379. Published online September 30, 2011

Crossref 3

Purpose

4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.

Methods

BALB/c mice were sensitized to and challenged with ovalbumin (OVA). Hu.4-1BB-Fc was administered 1 day before the first OVA...

DOI: https://doi.org/10.3345/kjp.2011.54.9.373

A Clinical Study of Childhood Systemic Lupus Erythematosus

Young-Jun Kim, Young Don Kim, Jae Hong Park, Su Young Kim, Hee-Ju Park

Clin Exp Pediatr. 1994;37(9):1235-1244. Published online September 15, 1994

To Evaluate the clinical characteristics of childhood-onset systemic lupus erythemoatosus (SLE) and analyse the factors related to outcome of renal function in lupus nephritis, we reviewed medical records of 18 cases of SLE diagnosed at the Department of Pediatrics, Pusan Nationsl University Hospital from January 1981 to December 1990. The results were as was 1:2.6 1)Male...

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