Clinical and Experimental Pediatrics

Review Article

Neonatology (Perinatology)

Association between surgical repair timing and mortality in neonates with congenital diaphragmatic hernia: a systematic review and meta-analysis

Veerabhadra Radhakrishna, Bharathi Balachander, Sanjana Hansoge Somanath, Hejmady Aneesh Shenoy, Srinivas Balachander

Clin Exp Pediatr. 2026;69(11):844-854. Published online September 17, 2026

Preoperative stabilization is critical for the management of congenital diaphragmatic hernias. Surgical repair within 24 hours of life significantly increases mortality risk. A 24- to 48-hour stabilization window optimizes survival and resource utilization. Delaying surgery beyond 48 hours offers no additional survival benefits and increases morbidity. In neonates requiring extracorporeal membrane oxygenation, the exact surgical timing does not independently predict mortality.

DOI: https://doi.org/10.3345/cep.2026.01837

Case Report

Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia

Yun Sil Chang, I-Seok Kang, Won Soon Park, Suk Koo Lee, Hun Hahk Kim, Heung Jae Lee

Clin Exp Pediatr. 1996;39(11):1611-1619. Published online November 15, 1996

Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for...

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Two Cases of Bochdalek's Hernia.

Sang Ki Hwang, Un Hee Choi, Sang Suck Ki, Hak Soo Lee, Byung Wha Lee, Heum Rea Park

Clin Exp Pediatr. 1985;28(7):720-725. Published online July 31, 1985

Congenital diaphragamatic anomaly is a rare congenital malformation and is found more frequently on the left side than the right side. We had experienced two cases of congenital diaphragmatic anomaly on the right and the left side. One case was 1 year old male infant which was admitted with chief complaints of fever and mild cough. The diagnosis was confirmed by...

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