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- Review Article
- Endocrinology
- Applications of genomic research in pediatric endocrine diseases
- Ja Hye Kim, Jin-Ho Choi
- Clin Exp Pediatr. 2023;66(12):520-530. Published online June 14, 2023
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· Recent advances in molecular genetics have improved our understanding of pediatric endocrine disorders and are now used in mainstream medical practice.
· Genome-wide association studies can increase our understanding of the biological mechanisms of disease and inform new therapeutic options.
· The identification of founder mutations leads to the efficient localization of the genes underlying Mendelian disorders.
· Next-generation sequencing technologies benefit clinical practice and research of pediatric endocrinology.
- Original Article
- Neurology
- Long-term neurological cognitive, behavioral, functional, and quality of life outcomes after fetal myelomeningocele closure: a systematic review
- Andre Marolop Pangihutan Siahaan, Martin Susanto, Sarma Nursani Lumbanraja, Dwi Herawati Ritonga
- Clin Exp Pediatr. 2023;66(1):38-45. Published online November 30, 2022
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· Fetal myelomeningocele closure significantly improved long-term neurological cognitive, behavioral, functional, and quality of life outcomes, most likely by reducing hydrocephalus rates.
· However, fetal myelomeningocele closure is associated with a significant risk of pregnancy complications, especially premature rupture of membranes and preterm delivery.
- Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats
- Hyeok Hee Kwon, Taekwan Lee, Jinpyo Hong, Dong Woon Kim, Joon Won Kang
- Clin Exp Pediatr. 2018;61(5):150-155. Published online May 28, 2018
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Purpose Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.
Methods We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their...
- Review Article
- Oncology
- Prognostic factors and treatment of pediatric acute lymphoblastic leukemia
- Jae Wook Lee, Bin Cho
- Clin Exp Pediatr. 2017;60(5):129-137. Published online May 31, 2017
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The event-free survival (EFS) for pediatric acute lymphoblastic leukemia (ALL) has shown remarkable improvement in the past several decades. In Korea also, a recent study showed 10-year EFS of 78.5%. Much of the improved outcome for pediatric ALL stems from the accurate identification of prognostic factors, the designation of risk group based on these factors, and treatment of appropriate duration...
- Original Article
- Oncology
- Metformin displays
in vitro andin vivo antitumor effect against osteosarcoma - Yunmi Ko, Aery Choi, Minyoung Lee, Jun Ah Lee
- Clin Exp Pediatr. 2016;59(9):374-380. Published online September 21, 2016
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Purpose Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research.
Methods We evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using...
- A prospective study to assess the efficacy and safety of oral propranolol as first-line treatment for infantile superficial hemangioma
- Yeong Ju Yun, Yun Hee Gyon, Sohyoung Yang, Youn Kyung Lee, Joohyun Park, Meerim Park
- Clin Exp Pediatr. 2015;58(12):484-490. Published online December 22, 2015
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Purpose To determine the efficacy and safety of oral propranolol as a first-line treatment for superficially located infantile hemangioma (IH) and propose an assessment tool to measure treatment response.
Methods Patients with superficial IH under 1 year of age were prospectively recruited between May 2012 and December 2013 at the Department of Pediatrics of Chungbuk National University Hospital. Propranolol was administered to 12...
- Review Article
- Systemic use of fluoroquinolone in children
- Soo-Han Choi, Eun Young Kim, Yae-Jean Kim
- Clin Exp Pediatr. 2013;56(5):196-201. Published online May 28, 2013
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Fluoroquinolones are an important class of antibiotics that are widely used in adult patients because of their broad spectrum of activity, good tissue penetration, and oral bioavailability. However, fluoroquinolone use in children is limited because juvenile animals developed arthropathy in previous experiments on fluoroquinolone use. Indications for fluoroquinolone use in patients younger than 18 years, as stated by the U.S....
- Original Article
- Neuroprotective effects of L-carnitine against oxygen-glucose deprivation in rat primary cortical neurons
- Yu Jin Kim, Soo Yoon Kim, Dong Kyung Sung, Yun Sil Chang, Won Soon Park
- Clin Exp Pediatr. 2012;55(7):238-248. Published online July 17, 2012
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Purpose Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and modulates excess acyl coenzyme A levels. In this study, we investigated whether treatment of primary cultures of rat cortical neurons with L-carnitine was able to prevent neurotoxicity resulting from oxygen-glucose deprivation...
- Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors
- Suntae Ji, Hee Won Chueh, Ju Youn Kim, Su Jin Lim, Eun Joo Cho, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
- Clin Exp Pediatr. 2011;54(3):128-132. Published online March 31, 2011
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Purpose Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in...
- Review Article
- Late physical effects of childhood cancer survivors
- Young-Ho Lee
- Clin Exp Pediatr. 2010;53(4):477-480. Published online April 15, 2010
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Advances in research and medical and supportive care have contributed to a growing population of adults formerly treated for childhood cancer. History of cancer and its therapy can have significant life-long health implications. Late effects of cancer therapy can be insidious on onset, occur outside the pediatric age, and contribute to premature morbidity and mortality. In this review, I have focused on the... -
- Original Article
- Ototoxicity in children receiving cisplatin chemotherapy
- Hee Jin Jang, Hyung Rae Cho, Jae Hee Lee, Kun Yuk Bae, Jong Jin Seo, Hyung Nam Moon, Ho Joon Im
- Clin Exp Pediatr. 2010;53(2):210-214. Published online February 15, 2010
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Purpose : Cisplatin is highly effective for the treatment of solid tumors in children. However, the clinical use of cisplatin is limited by its ototoxicity. The aim of this study was to evaluate the ototoxicity in children treated with cisplatin. Methods : We performed a single institution retrospective analysis of pediatric oncology patients who received cisplatin therapy between January 2001 and... -
- Review Article
- Environmental tobacco smoke and childhood asthma
- Dae Jin Song
- Clin Exp Pediatr. 2010;53(2):121-128. Published online February 15, 2010
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In recent years, environmental tobacco smoke (ETS) has become an important worldwide public health issue. Children are particularly vulnerable to ETS because they are still developing. ETS exposure causes a wide range of adverse health effects on childhood asthma. There is convincing evidence that ETS exposure is causally associated with an increased prevalence of asthma, increased severity of asthma and... -
- Original Article
- Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats
- Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
- Clin Exp Pediatr. 2009;52(12):1337-1347. Published online December 15, 2009
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Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral... -
- Economic evaluation of a weekly administration of a sustained-release injection of recombinant human growth hormone for the treatment of children with growth hormone deficiency
- Hye-Young Kang, Duk Hee Kim, Sei-Won Yang, Yoon-Nam Kim, Miseon Kim
- Clin Exp Pediatr. 2009;52(11):1249-1259. Published online November 15, 2009
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Purpose : From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. Methods : Health-related utility for GH therapy was measured based on the visual analogue scale. During July... -
- A study on the toilet training and influencing factors
- Eun Ok Kim, Sang Hyun Yun, Young Taek Jang
- Clin Exp Pediatr. 2009;52(7):778-784. Published online July 15, 2009
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Purpose : We aimed to determine the ideal age for initiating toilet training and investigate the factors influencing the training. Methods : The study population comprised 1,370 children aged 2-6 years, who visited the pediatric clinics in Jeonju, Iksan, and Gunsan. Their parents were given questionnaires in order to gather data about the types of diapers used, ages when toilet training... -
- Bilateral retinoblastoma: Long-term follow-up results from a single institution
- Sang Yul Choi, Dong Hwan Kim, Kang Min Lee, Hyun Jae Lee, Mi-Sook Kim, Tai-Won Lee, Sang Wook Choi, Dong Ho Kim, Kyung Duk Park, Jun Ah Lee
- Clin Exp Pediatr. 2009;52(6):674-679. Published online June 15, 2009
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Purpose : The authors aimed to analyze the long-term effects of treatments, especially external beam radiotherapy (EBRT), in bilateral retinoblastoma patients. Methods : This retrospective study analyzed the medical records of 22 bilateral retinoblastoma patients who were registered between October, 1987 and October, 1998 and followed-up for more than 10 years. They were treated by enucleation, EBRT, and systemic chemotherapy.... -
- Safety and efficacy of the ultra-rush immunotherapy with extracts of Dermatophagoides pteronyssinus in children
- Sei Eun Hyun, Hyoung Yun Kim, Ji Hee Kwak, Youn Ho Shin, Ji Yeong Seo, Man Yong Han
- Clin Exp Pediatr. 2008;51(8):868-873. Published online August 15, 2008
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Purpose : Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods : Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive... -
- Effects and adverse-effects of growth hormone therapy in children with Prader-Willi syndrome: A two year study
- Su Jin Kim, Joong Bum Cho, Min Jung Kwak, Eun Kyung Kwon, Kyung Hoon Paik, Dong-Kyu Jin
- Clin Exp Pediatr. 2008;51(7):742-746. Published online July 15, 2008
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Purpose : The objective of this study was to evaluate the effects and adverse side-effects of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS). Methods : Forty-one patients who had been treated with GH for more than two years (24 boys and 17 girls, mean age 7.3?.3 years during treatment initiation) were enrolled for this study. Results : After... -
- Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
- Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
- Clin Exp Pediatr. 2006;49(7):790-795. Published online July 15, 2006
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Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD). Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to... -
- Effect of maternal thyroxine treatment on the offspring's brain development with fetal alcohol effects in the rats
- Jin Fu, Yoon Young Chung, Sang Kee Park
- Clin Exp Pediatr. 2006;49(6):677-685. Published online June 15, 2006
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Purpose : This study aimed to investigate whether exogenous thyroxine(T4) treatment to alcohol-fed dams would ameliorate the detrimental effects of alcohol on the postnatal development of neuropeptide-Y(NPY)-containing neurons of the cerebral cortex and hippocampus of the offspring. Methods : Time-pregnant rats were divided into three groups. An alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day... -
- The Safety and Immunogenicity of a Trivalent, Live, Attenuated MMR Vaccine, PriorixTM
- Seung-In Ahn, Min-Kook Chung, Jung-Suk Yoo, Hye-Jeon Chung, Jae-Kyun Hur, Young-Kyu Shin, Jin-Keun Chang, Sung-Ho Cha
- Clin Exp Pediatr. 2005;48(9):960-968. Published online September 15, 2005
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Purpose : This multi-center, open-label, clinical study was designed to evaluate the safety and immunogenicity of a trivalent, live, attenuated measles-mumps-rubella(MMR) vaccine, PriorixTM in Korean children. Methods : From July 2002 to February 2003, a total of 252 children, aged 12-15 months or 4-6 years, received PriorixTM at four centers : Han-il General Hospital, Kyunghee University Hospital, St. Paul's Hospital at... -
- The Efficacy of Speech and Language Therapy for Children with Speech and Language Delays according to the Eiologies
- June-Bum Kim, Jin-Soon Suh, Young-Hoon Kim, Seung-Yun Chung, In-Goo Lee, Kyung-Tai Whang, Byung-Churl Lee
- Clin Exp Pediatr. 2005;48(9):924-928. Published online September 15, 2005
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Purpose : Treatment efficacy for children with speech and language delay has been the subject of considerable debate in recent years. We evaluated the clinical features of children with delayed speech and language and their prognoses according to their etiologies after 6 months of speech and language therapy. Methods : From January, 2000 to March, 2004, we retrospectively reviewed 56... -
- Allogeneic Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia
- Keon Hee Yoo, Dong Kil You, Soo Hyun Lee, Ki Woong Sung, Eun Joo Cho, Hong Hoe Koo
- Clin Exp Pediatr. 2005;48(2):178-185. Published online February 15, 2005
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Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo- HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ?13-cis-retinoic acid(CRA) before... -
- Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
- Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
- Clin Exp Pediatr. 2004;47(2):193-203. Published online February 15, 2004
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Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and... -
- A Study of the Effects and Risks of Baby-walkers on Motor Development in Human Infants
- Ji Young Lee, Sae Ah Min, Sun Hee Yu, Young Taek Jang
- Clin Exp Pediatr. 2003;46(2):122-127. Published online February 15, 2003
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Purpose : Baby-walkers are used by many parents because of the convenience they provide in keeping children occupied, quiet, happy, and in stimulating ambulation. But, these devices have more risks than benefits. Therefore, we performed a study to evaluate the effects of baby-walkers on motor development of human infants according to the hours used in a day, total duration(months), and... -
- Analgesic Effect of Sugar Solution in Infantile Colic
- Jong Seok Kim, Kyung Ho Kwon, Young A Lee, Hyeon Jeong Kim, Kyun Woo Lee
- Clin Exp Pediatr. 2002;45(6):712-718. Published online June 15, 2002
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Purpose : Infantile colic is one of the most commonly encountered problems, characterized by excessive crying in apparently healthy young infants within the first 3 months of life. It is commonly assumed that the infant with colic has distress and possible pain. In recent investigations, it has been found that sucrose has an analgesic effect in newborn infants. The purpose... -
- A Study of the Bystander Effect and Its Enhancement in HSV-TK Gene Therapy Using a Murine Neuroblastoma Model
- Hyun Sang Cho, Moon Kyu Kim, Chong Young Park
- Clin Exp Pediatr. 2002;45(3):354-361. Published online March 15, 2002
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Purpose : Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We first investigated the bystander effect of retrovirus-mediated gene transfer of herpes simplex virus thymidine kinase(HSV-TK) gene to murine neuroblstoma cell line(neuro-2a) in vitro and in vivo. Second, we examined the mechanism and its enhancement of the bystander effect in murine neuroblastoma. Methods... -
- The Effect of Soothing Classic Music on the Behavior and Initial Weight Loss of Newborn Infants
- Min Jung Cho, Son Moon Shin
- Clin Exp Pediatr. 2001;44(12):1381-1386. Published online December 15, 2001
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Purpose : As there are some reports that music affects some physiological parameters and behavior of preterm infants, we have attempted to evaluate the effect of soothing classic music on the behavior and initial weight loss of full term infants. Methods : A clinical study was conducted on newborn infants born at Youngnam University Hospital from July to August, 1999. Forty normal full term... -
- Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma
- Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee
- Clin Exp Pediatr. 2001;44(11):1249-1253. Published online November 15, 2001
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Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK＋ or HSV-TK－ were plated into culture plates and treated with GCV for... -
- Effect of Vitamin E on Cerebral Hypoxia-Ischemia in Neonatal Rats
- Jung Eun Seok, Yeon Kyun Oh, Seung Taek Park
- Clin Exp Pediatr. 2001;44(7):764-772. Published online July 15, 2001
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Purpose : In order to evaluate the hypoxia-ischemia induced neurotoxic effect and the protective effect of vitamin E as an antioxidant, cell number and cell viability were measured in cerebral neurons and astrocytes derived in neonatal rats. Methods : 7-day old neonatal rats were subjected to unilateral common carotid artery occlusion, and exposed to hypoxic condition for 3 hours. The protective... -
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