Clinical and Experimental Pediatrics

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Original Article

Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression

Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang

Clin Exp Pediatr. 2000;43(7):942-951. Published online July 15, 2000

Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...

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