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Original Article
Prednisolone impairs trabecular bone score changes in adolescents with 21-hydroxylase deficiency
Pattara Wiromrat, Yutapong Raruenrom, Phanpaphorn Namphaisan, Nantaporn Wongsurawat, Ouyporn Panamonta, Chatlert Pongchaiyakul
Background: Individuals with 21-hydroxylase deficiency (21OHD) require lifelong glucocorticoid (GC) therapy, which increases their risk of fragility fractures. However, fractures in GC-treated individuals can occur at normal bone mineral density (BMD) levels, suggesting an alteration in the bone microarchitecture.
Purpose: To evaluate trabecular bone microarchitecture and its changes in adolescents with 21OHD. Methods: We enrolled 38 adolescents with 21OHD for whom...
Review Article
Evidence for adverse effect of perinatal glucocorticoid use on the developing brain
Young Pyo Chang
Clin Exp Pediatr. 2014;57(3):101-109.   Published online March 31, 2014

The use of glucocorticoids (GCs) in the perinatal period is suspected of being associated with adverse effects on long-term neurodevelopmental outcomes for preterm infants. Repeated administration of antenatal GCs to mothers at risk of preterm birth may adversely affect fetal growth and head circumference. Fetal exposure to excess GCs during critical periods of brain development may profoundly modify the limbic...

Original Article
Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line
Sun-Young Kim, Kyung-Yil Lee, Dae-Chul Jeong, Hak-Ki Kim
Clin Exp Pediatr. 2010;53(7):753-758.   Published online July 31, 2010
Purpose

It has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified. We evaluated the relationship between the GC response and p16 expression in a lymphoma cell line.

Methods

We used p16 siRNA transfection to construct p16-inactivated cells by using the B-cell lymphoblast cell line NC-37. We compared glucocorticoid...

Polymorphisms of the NR3C1 gene in Korean children with nephrotic syndrome
Hee Yeon Cho, Hyun Jin Choi, So Hee Lee, Hyun Kyung Lee, Hee Kyung Kang, Il Soo Ha, Yong Choi, Hae Il Cheong
Clin Exp Pediatr. 2009;52(11):1260-1266.   Published online November 15, 2009
Purpose : Idiopathic nephrotic syndrome (NS) can be clinically classified as steroid-sensitive and steroid-resistant. The detailed mechanism of glucocorticoid action in NS is currently unknown. Methods : In this study, we investigated 3 known single nucleotide polymorphisms (SNPs) (ER22/23EK, N363S, and BclI) of the glucocorticoid receptor gene (the NR3C1 gene) in 190 children with NS using polymerase chain reaction-restriction fragment...
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Case Report
Three Cases of Familial Glucocorticoid Deficiency.
Soo Heum Lim, Young Wun Kim, Byoung Hai Ahn, Hyung Ro Moon
Clin Exp Pediatr. 1986;29(5):549-552.   Published online May 31, 1986
Familial glucocorticoid defiency is a form of chronic adrenal insufficiency which is characterized by isolated deficiency of glucocorticoid and elevated levels of corticotropin in association with normal aldosterone production. It is thought to be degenerative process of adrenal cortex, with autosomal recessive or X-linked recessive pattern of inheritance. Skin hyperpigmentation and hypoglycemic symptom are characteristic and salt-losing symptom doesn’t develop....
Original Article
Effect of the Glucocorticoids on the Vertebral Bone Density in Children with the Nephrotic Syndrome
Jong Young Kim, Yong Hoon Park
Clin Exp Pediatr. 1955;38(7):946-954.
Purpose : This study was conducted to evaluate that long term glucocorticoid treatment in children with the nephrotic syndrome can produce a significant loss of bone mass by measuring of bone mineral density(BMD) Methods : We measured BMD at lumbar vertebra(L2-L4) using dual enegy X-ray absorptiom-etry in 36 patients with the nephrotic syndrome who were administered prednisolone over 6 months and...