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Original Article

Effect of growth hormone on neuronal death in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation

Kyung Sik Hong, Jihui Kang, Myeung Ju Kim, Jeesuk Yu, Young Pyo Chang

Clin Exp Pediatr. 2009;52(5):588-593. Published online May 15, 2009

Purpose : To investigate whether growth hormone (GH) has a protective effect on neurons in hippocampal slice cultures of neonatal rats exposed to oxygen-glucose deprivation (OGD). Methods : Cultured hippocampal slices of 7-day-old rats were exposed to OGD for 60 min. Then, the slices were immediately treated with three doses of GH (5, 50, or 500 µM) in media. The...

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