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Review Article
Hemolytic anemia in pediatrics
Jeong Ok Hah
Clin Exp Pediatr. 2007;50(6):511-518.   Published online June 15, 2007
To understand the hemolytic anemia (HA) in children, the diagnostic approach and management of hereditary and acquired HA are described. The hereditary hemolytic anemia (HHA) can be classified according to the pathogenesis into three types : RBC membrane defects, hemoglobinopathies, and RBC enzymopathies. Clinical characteristics, laboratory findings and molecular defects of these three types are presented briefly. In Korea,...
Case Report
A case of dapsone syndrome
Yoo Jong Won, Ok Lan Kim, Seung Taek Yu, Young Wook Yoon, Du Young Choi
Clin Exp Pediatr. 2007;50(5):493-496.   Published online May 15, 2007
Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the...
A Case of Rothmund-Thomson Syndrome with Pure Red Cell Aplasia, Autoimmune Hemolytic Anemia and Chronic Respiratory Infection
Jung Hyun Lee, Eun Seok Roh, Yoo Rah Hong, Jae Sun Park, Ghi Seok Seo, Bang Hur, Mi Hyang Kim
Clin Exp Pediatr. 2004;47(12):1351-1355.   Published online December 15, 2004
Rothmund-Thomson syndrome(RTS), or poikiloderma congenita, is a rare, multisystem disorder. It is inherited genetically as an autosomal recessive trait, occurring predominantly in females(1.4 : 1). The RTS is comprised of poikiloderma, short stature, sparse hair, juvenile cataracts, skeletal defects, dystrophic teeth and nails, photosensitivity, and hypogonadism. We report a case of RTS who died of bleeding from esophageal varices, pulmonary...
Original Article
A Clinical Study on Childhood Hemolytic Anemia According to Etiological Classification
Hae-Sik Kwon, Jung-Chul Kang, Sung-Chul Won, Seung-Hwan Oh, Chuhl-Joo Lyu
Clin Exp Pediatr. 2003;46(9):883-888.   Published online September 15, 2003
Purpose : The etiology of hemolytic anemia can be classified as either cellular or extracellular defects of red blood cells. The aim of this study was to investigate the clinical and laboratory findings of hemolytic anemia concerning its etiological classification. Methods : Clinical and laboratory findings of the patients with hemolytic anemia treated from January 1987 to May 2002 at Severance...
Case Report
A Case of Common Variable Immunodeficiency with Autoimmune Hemolytic Anemia
Kyung-Yil Lee, Yon-Joo Lee, Sang-Won Cha, Dong Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Joong-Gon Kim
Clin Exp Pediatr. 2000;43(1):117-122.   Published online January 15, 2000
Common variable immunodeficiency(CVID) is a heterogeneous collection of disorders with hypogammaglobulinemia with recurrent bacterial infections and high incidence of autoimmune disorders as its hallmark. We report a 7-year-old girl suffering from CVID with Coombs' test positive hemolytic anemia. She had been relatively well until 23-months old when she was admitted to Taejon St. Mary' s Hospital with pneumonia 5 years ago. Afterwards, she had...
A Case of Wilson Disease Associated with Hemolytic Anemia and Cholelithiasis
Kyeong Cheol Yoon, Yong Hwa Shin, Ho Seek Ahn, Sung Won Kim
Clin Exp Pediatr. 1992;35(11):1573-1577.   Published online November 15, 1992
Wilson disease is an autosomal recessive abnormality in the hepatic excretion of copper that results in toxic accumulation of the metal in liver, brain, and other organs. Hemolytic anemia frequently complicates the courses of Wilson disease and may be the initial clinical feature of Wilson disease. Since hemolysis may be preceding the onset of hepatic manifestation and Kayser-Fleischer ring is...
Original Article
A case of pancytopenia associated with mycoplasmal pneumonia.
Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
Clin Exp Pediatr. 1991;34(6):826-831.   Published online June 30, 1991
Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes- tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm- bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate, positive direct Coombs test, reticulocytosis and DIC are known hematologic features. This 12 years old female patient was presented with pneumonia and pancytopenia....
A Case of Autoimmune Hemolytic Anemia Associated with Chronic Hepatitis in Children.
Kwan Mo Choi, Kyeong Hun Cha, Eun Yeong Kwak, Kyung Rae Moon, Yeong Bong Park
Clin Exp Pediatr. 1990;33(9):1288-1293.   Published online September 30, 1990
Recently, We experienced a case of autoimmune hemolytic anemia in a 13 year old female patient associated with chronic hepatitis. This female child manifested severe pallor, jaundice, abdominal pain and fever. This diagnosis was made on the bases of typical clinical features, C.B.C., blood chemistry, coombs test, warm antibody, immunoelectrophoresis, peripheral blood smear and bone marrow examination. The patient improved with steroid therapy. We report this...
The Effect of Oral Vitamin E on Hemolytic Anemia of the Premature Infants.
Hwa Kyoung Oh, Kwang Sik Yoo, Yong Sil Chi, Myung Jin Kim, Mi Na Lee
Clin Exp Pediatr. 1989;32(11):1469-1473.   Published online November 30, 1989
The study was designed to evaluate the effect of vitamin E on hemolytic anemia of premature infants. Sixty infants delivered in Cheil Hospital from March 1987 to December 1988 with birth weight below 2500 gm or gestational age below 37 weeks were studied. Thirty infants received oral vitamin E 25 IU/day until their birth weight doubled. Thirty infants served as control. The results were...
A Case of Hemolytic Disease of Newborn due to Anti-E.
Sang Keun Oh, Youn O Park, hyun Sook Seo, Mi Sook Park, Young Chul Lee, Hee Dae Park, Hee Joo Lee
Clin Exp Pediatr. 1988;31(8):1059-1063.   Published online August 31, 1988
A 2-day-old male infant was admitted to the Incheon Christian Hospital due to severe jaundice. He was a third baby and his Rh phenotype was CcDEe. The direct antiglobulin test of the infant was strong positive. Eluates that were made from the infanfs elder brother and sister were both CDe. Her two previous infants showed no evidence of erythroblastosis. She had a past...
Case Report
A Case of Autoimmune Hemolytic Anemia Associated with Acute Viral Hepatitis B.
Chong Kyu Woo, Eun Kyung Choi, Hae Ryung Chung, Dong Heuk Keum
Clin Exp Pediatr. 1987;30(9):1034-1039.   Published online September 30, 1987
We experienced a case of autoimmune hemolytic anemia in 3-year-old male patient associated with acute viral hepatitis B. Characteristic findings of this disease are pallor, fever, tachycardia, jaundice, hemoglobinuria, of which the onset is acute or chronic. Although the pathogenic mechanism of this disease is uncertain, it can be associated with pneumonia, measles, varicella, viral hepatitis (50%) and underlying autoinunune deficiency (32%). Diagnosis...
A Case of Congenital Nonspherocytic Hemolytic Anemia.
Tae Sook Kim, Sang Bae Jeon, Bok Yang Pyun
Clin Exp Pediatr. 1985;28(6):597-603.   Published online June 30, 1985
We observed a case of congenital nonspherocytic hemolytic anemia who was a 24 month old boy with the signs of jaundice 技 pallor. Evidences of the same disease was also found in the patient' s elder brother & father. We diagnosed these cases by history & physical examination, peripheral & B.M. blood smears, osmotic fragility test, autohemolysis test and etc. A...
Original Article
Clinical Observation of Hemolytic Anemia in Children Except Isoimmunization.
Hak Yong Kim, Young Mo Sohn, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1981;24(12):1149-1156.   Published online December 15, 1981
Hemolytic anemia is caused by early destruction of red cells and there are many etiologies,ecently, prosthetic devices are used frequently to correct cardiac diseases and they also cause hemolytic anemia. We performed clinical analysis of 74 patients with hemolytie anemia who had been diagnosed at Severance hospital in recent 10 years. Results were as follows: 1)In 74 cases, male were 46...